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RISS 인기검색어
- 검색키워드
- 저자 : Heinrich Bollwein (검색결과 5 건)
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Maike Heppelmann,Lars Krüger,Stephanie Leidl,Heinrich Bollwein 대한수의학회 2013 Journal of Veterinary Science Vol.14 No.3
Transrectal Doppler sonography was used to evaluate uterine blood flow during the first two weeks after parturition in six primiparous Simmental cows. The uterine blood flow was evaluated on the day of parturition (Day 0),once daily from Days 1 to 8 and then every other day until Day 14. Blood flow was quantified by determining the diameter (D), the time-averaged maximum velocity (TAMV), the pulsatility index (PI) and the blood flow volume (BFV) of the uterine arteries ipsilateral and contralateral to the formerly pregnant uterine horn. During the first four days after calving D, TAMV and BFV declined (ipsilateral:TAMV 70%, BFV 87%, contralateral: D 47%, BFV 84%; p < 0.05), while PI increased (ipsilateral 158%, contralateral 100%; p < 0.05) distinctly. Between Days 4 and 14 only the ipsilateral D (12%) and the BFV of both arteries (ipsilateral 5%, contralateral 8%) decreased (p < 0.05). Blood flow variables were very strongly correlated with each other (r >±0.75, p < 0.05), with negative correlations with PI and positive correlations with all other investigated factors. Overall, this study revealed characteristic changes in uterine perfusion during the first two weeks after parturition in cows that were pronounced during the first four days postpartum.
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Effect of oxytocin infusion on luteal blood flow and progesterone secretion in dairy cattle
Christos N. Brozos,Metin S. Pancarci,Javier Valencia,Nikola Beindorff,Evaggelos Kiossis,Heinrich Bollwein,Georgios Tsousis 대한수의학회 2012 Journal of Veterinary Science Vol.13 No.1
The objective of this study was to investigate the effects of oxytocin infusion on corpus luteum (CL) function during early to mid-diestrus by measuring luteal size (LS) and luteal blood flow (LBF) along with plasma levels of progesterone (P4) and prostaglandin metabolites (13,14-dihydro-15-keto-prostaglandin F2a, PGFM). On day (D) 7 of the estrus cycle (D1 = ovulation), seven cows received 100 IU of oxytocin (OXY) or placebo (PL) following a Latin square design. LS and LBF increased in both groups over time and no differences were observed between the groups. PGFM did not differ either within the groups over time or between the groups at any time point. P4 of the OXY group was higher compared to that of the the PL group 360 min after the infusion (p = 0.01) and tended to be higher at the time points 450 min, 48 h, and 72 h (all p = 0.08). Results from this study support the hypothesis that OXY is not directly involved in the mechanism(s) governing blood flow of the CL and has no remarkable effects either on luteal size or P4 and PGFM plasma levels. Further investigation is needed to elucidate the role of OXY in CL blood flow during early and late luteal phases.
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Annette Forro,Georgios Tsousis,Nicola Beindorff,Ahmad Reza Sharifi,Christos Brozos,Heinrich Bollwein 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.1
The objective of this study was to investigate factors that influence the success of resynchronization protocols for bovines with and withoutprogesterone supplementation. Cow synchronized and not found pregnant were randomly assigned to two resynchronization protocols:ovsynch without progesterone (P4) supplementation (n = 66) or with exogenous P4 administered from Days 0 to 7 (n = 67). Progesteronelevels were measured on Days 0 and 7 of these protocols as well as 4 and 5 days post-insemination. Progesterone supplementation raised theP4 levels on Day 7 (p < 0.05), but had no overall effect on resynchronization rates (RRs) or pregnancy per artificial insemination (P/AI). However, cows with Body Condition Score (BCS) > 3.5 had increased P/AI values while cows with BCS < 2.75 had decreased P/AI ratesafter P4 supplementation. Primiparous cows had higher P4 values on Day 7 than pluriparous animals (p = 0.04) and tended to have higherRRs (p = 0.06). Results of this study indicate that progesterone supplementation in resynchronization protocols has minimal effects onoutcomes. Parity had an effect on the levels of circulating progesterone at initiation of the protocol, which in turn influenced the RR.
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Marion Piechotta,Lars Holzhausen,Marcelo Gil Araujo,Maike Heppelmann,Anja Sipka,Chistiane Pfarrer,Hans-Joachim Schuberth,Heinrich Bollwein 대한수의학회 2014 JOURNAL OF VETERINARY SCIENCE Vol.15 No.3
Cows with different Insulin-like Growth Factor-I (IGF-I)concentrations showed comparable expression levels of hepaticgrowth hormone receptor (GHR). Suppressor of cytokinesignaling 2 (SOCS2), could be responsible for additionalinhibition of the GHR signal cascade. The aims were to monitorcows with high or low antepartal IGF-I concentrations(IGF-Ihigh or IGF-Ilow), evaluate the interrelationships ofendocrine endpoints, and measure hepatic SOCS2 expression. Dairy cows (n = 20) were selected (240 to 254 days after artificialinsemination (AI)). Blood samples were drawn daily (day −17until calving) and IGF-I, GH, insulin, thyroid hormones,estradiol, and progesterone concentrations were measured. Liver biopsies were taken (day 264 ± 1 after AI and postpartum)to measure mRNA expression (IGF-I, IGFBP-2, IGFBP-3,IGFBP-4, acid labile subunit (ALS), SOCS2, deiodinase1,GHR1A). IGF-I concentrations in the two groups were different(p < 0.0001). However, GH concentrations and GHR1A mRNAexpression were comparable (p > 0.05). Thyroxine levels andALS expression were higher in the IGF-Ihigh cows compared toIGF-Ilow cows. Estradiol concentration tended to be greater inthe IGF-Ilow group (p = 0.06). It was hypothesized that low IGF-Ilevels are associated with enhanced SOCS2 expression althoughthis could not be decisively confirmed by the present study.
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Letizia Debertolis,Gaetano Mari,Barbara Merlo,Sabine Merbach,Heinz-Adolf Schoon,Eleonora Iacono,Heinrich Bollwein 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.2
This study was conducted to evaluate the effects of induced endometritis on uterine blood flow in cows. Transrectal Doppler sonography was performed on uterine arteries of six cyclic cows before and for 4 days after inducing acute endometritis by intrauterine infusion of 720 mg of policresulen, and for 4 days of the following estrous cycle. Time-averaged maximum velocity (TAMV) increased (p < 0.001) and pulsatility index (PI) decreased (p < 0.0001) within 1 h of policresulen administration, and did not change (p > 0.05) in the next 4 days of the same cycle. TAMV and PI values in the subsequent cycle did not differ (p > 0.05) from the values measured before infusion and showed no changes (p > 0.05) within the cycle. Blood flow parameters were not related (p > 0.05) to plasma concentrations of progesterone and estrogen. All cows showed an acute endometritis determined by histopathological findings of biopsy samples taken 1 day after infusion and fibrotic endometrial alterations detected in the subsequent cycle. No relationships were observed between fibrotic changes of the endometrium and uterine blood flow during either cycle. In conclusion, acute inflammation is accompanied by a rise in uterine blood flow, but fibrotic alterations do not seem to be related to Doppler sonographic findings.
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