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Controlled Drug Delivery: Transition to Nanosystems
권일근,박기남,Hatem Hegazy 한국생체재료학회 2006 생체재료학회지 Vol.10 No.3
Over the past few decades, drug delivery systems have advanced significantly to deliver novel drug entities, such as proteins and oligonucleotides, and a number of drug delivery technologies involving smart polymers have been developed. Polymers have been essential in the development of controlled release dosage forms, as they offer a wide range of physicochemical properties, such as aqueous solubility, biodegradability, and molecular weight. Furthermore, emergence of drug delivery techniques such as smart hydrogels, micelles, liposomes, and PEGylation has improved the bioavailability of poorly soluble drugs, protein therapeutics, and other drugs. New approaches in designing better drug delivery systems involve the use of nanotechnology to create polymer particles in the nano range and/or incorporate these nanoparticles into microdevices to allow better control of drug release and more efficient drug targeting.