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Lee, Changwook,Park, Hye-Kyung,Jeong, Hanbin,Lim, Jaehwa,Lee, An-Jung,Cheon, Keun Young,Kim, Chul-Su,Thomas, Ajesh P.,Bae, Boram,Kim, Nam Doo,Kim, Seong Heon,Suh, Pann-Ghill,Ryu, Ja-Hyoung,Kang, Byoun American Chemical Society 2015 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.137 No.13
<P>The mitochondrial pool of Hsp90 and its mitochondrial paralogue, TRAP1, suppresses cell death and reprograms energy metabolism in cancer cells; therefore, Hsp90 and TRAP1 have been suggested as target proteins for anticancer drug development. Here, we report that the actual target protein in cancer cell mitochondria is TRAP1, and current Hsp90 inhibitors cannot effectively inactivate TRAP1 because of their insufficient accumulation in the mitochondria. To develop mitochondrial TRAP1 inhibitors, we determined the crystal structures of human TRAP1 complexed with Hsp90 inhibitors. The isopropyl amine of the Hsp90 inhibitor PU-H71 was replaced with the mitochondria-targeting moiety triphenylphosphonium to produce SMTIN-P01. SMTIN-P01 showed a different mode of action from the nontargeted PU-H71, as well as much improved cytotoxicity to cancer cells. In addition, we determined the structure of a TRAP1–adenylyl-imidodiphosphate (AMP-PNP) complex. On the basis of comparative analysis of TRAP1 structures, we propose a molecular mechanism of ATP hydrolysis that is crucial for chaperone function.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2015/jacsat.2015.137.issue-13/ja511893n/production/images/medium/ja-2014-11893n_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja511893n'>ACS Electronic Supporting Info</A></P>
일반 대학생의 이미지 상상훈련이 정적 및 동적 균형에 미치는 영향
남형천 ( Hyoungchun Nam ),임경일 ( Kyungil Lim ),김수현 ( Suhyeon Kim ),김설지 ( Seoji Kim ),김지선 ( Jiseon Kim ),류영우 ( Youngwoo Ryu ),박인애 ( Inae Park ),이수빈 ( Subin Lee ),진한빈 ( Hanbin Jin ),문준석 ( Junseok Moon ),장세훈 대한통합의학회 2014 대한통합의학회지 Vol.2 No.2
Purpose : This study was to investigate the influence of imagery balance for healthy normal people in their twenties.Method : The study has taken a place in Kyung-buk college in Yung-jusi in Kyungbuk with a group of 21 healthy peoples. The study used measurement of good balance. we measured balance for data of each static and dynamic. Training period, a total of 2 weeks. Except Saturday and Sunday, the study did weekdays. Fist, 2-minute relaxation. Second, 6-minute imagine training. Third, 2-minute relaxation. Total 10-minute training was conducted per training. Result : In study, the subjects were compared date for before the study to date for after the study. The subjects showed a little change in each Balance. But, the improvement of balance was not a big change. Conclusion : Image training kinesthetic image using hearing improved incompletely inspite of being no gap, numerically balance