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Bohai Feng,Haijie Xiang,Haiyong Jin,Jinjian Gao,Saiyu Huang,Yunbin Shi,Ruru Chen,Bobei Chen 대한천식알레르기학회 2017 Allergy, Asthma & Immunology Research Vol.9 No.3
Purpose: Allergic rhinitis (AR) has become a global issue for a large part of the general population. Sublingual immunotherapy (SLIT) has been used extensively to treat persistent allergic rhinitis (PAR). Although systematic reviews have confirmed the effectiveness of SLIT for the treatment of AR, a considerable number of studies using extracts of house dust mites (HDMs) for immunotherapy found no consensus on basic treatment parameters and questioned the efficacy of SLIT. Methods: In this study, we evaluated SLIT for PAR by a meta-analysis of randomized controlled trials (RCTs). Medline, Embase, and Cochrane Library database searches were performed for RCTs on the treatment of PAR by SLIT that assessed clinical outcomes related to efficacy through May 2016. Descriptive and quantitative information was abstracted. An analysis was performed with standardized mean differences (SMDs) under a fixed or random effects model. Subgroup analyses were performed. Heterogeneity was assessed using the I2 metric. Results: In total, 25 studies were eligible for inclusion in the meta-analysis for symptom scores and 15 studies for medication scores. SLIT was significantly different from the controls for symptom scores (SMD=1.23; 95% confidence interval [CI]=1.74 to 0.73; P<0.001). For medication scores, significant differences for SLIT were also observed versus the controls (SMD=-1.39; 95% CI=-1.90 to -0.88; P<0.001). Conclusions: Our meta-analysis indicates that SLIT provided significant symptom relief and reduced the need for medications in PAR. In this study, significant evidence was obtained despite heterogeneity with regard to the use of mite extract. Specifically, the mite extract used was provided by the patients with PAR. Furthermore, to confirm both the objective outcomes and the effective doses of HDM allergen extracts, experimental data should be obtained from large high-quality population-based studies.
Shaogan Ye,Junhui Zhang,Bing Xu,Wei Song,Long Chen,Haiyong Shi,Shiqiang Zhu 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.9
Erosion damage affects the reliability and durability of axial piston pumps. An axial piston pump was tested using endurance life testing method. The phenomenon of erosion damage on the valve plate was observed using a confocal laser scanning microscope, by comparing the surface on the valve plate before and after the endurance life testing. A CFD turbulence model inclusive of the cavitation effects was developed to predict the flow physics. The flow physics in the axial piston pump were presented and analyzed, including the fluid velocities, velocity fields, the total volume fraction fields of gas and vapor, and pressure fields. Two causes of erosion damage were found, the appearances of large amount of vapor, and directly hitting by the jetting flow. The first one is the cause of erosion damage on the surface near the transition region from the inlet port to the outlet port, and the second one is the cause of erosion damage on the surface near the transition region from the outlet port to the inlet port. Besides, the findings show that the fluid velocities closely relate to the area of erosion damage. The study provides insights into the occurrence of erosion damage in axial piston pumps.