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Jyoti Kaushal,Madhu Khatri,Gursharan Singh,Shailendra Kumar Arya 한국생물공학회 2024 Biotechnology and Bioprocess Engineering Vol.29 No.1
Bacillus pumilus , a bacterial strain was isolated from agricultural soil and used for xylanase enzyme (Xy) production under the submerged fermentation technique. The (Xy) enzyme had an optimum temperature at 50 (maximum activity from 45–60 °C) and was active at broad pH range (5.0–8.0) with an optimum pH at around 6.3 as evaluated from response surface methodology studies. This enzyme after purifi cation (purifi cation; 2.87 folds, specifi c activity; 64.3 U/mg) was immobilized onto MOF Cu-BTC (a copper ion-based metal organic framework) and was used for clarifi cation of freshly squeezed fruit juice (pineapple and pomegranate). The study revealed an improved catalytic effi ciency ( V max from 1.252.5 to 1.361 U/mL/ mg of support) and greater half-life of the immobilized system (77–99 min). The activation energy decreased from that required for the free system (37.59–25.63 kJ/mol). The reusability of the enzyme improved after immobilization where 61% of the enzyme’s activity was retained after 21 cycles of usage. The MOF Xy-Cu-BTC system showed improved clarifi cation (47.58–57.97% for pineapple, and 15.34–18.3 for pomegranate) thereby showing its eff ectiveness in commercial juice clarifi cation process.
Fibrolamellar variant of hepatocellular carcinoma presenting during pregnancy
Nagalapuram Vishnu,Aditya V Kulkarni,Sreenivasan Vidhyalakshmi,Swaminathan Sambandam,Prerna Garg,Venkatakrishnan LeelaKrishnan,Krishnaveni Janarthan,Gursharan Singh,Maninder Kaur,TV Chitra,Biku Joseph 한국간담췌외과학회 2017 Annals of hepato-biliary-pancreatic surgery Vol.21 No.1
The Fibrolamellar variant of Hepatocellular Carcinoma (FLHCC) is a rare form of liver cancer that presents in the 3<SUP>rd</SUP> decade of life, is rarely associated with cirrhosis or chronic Hepatitis B/C virus infection, and usually presents with normal serum alpha-fetoprotein (AFP) levels. FLHCC presenting during pregnancy is extremely rare, with only 4 cases reported. We present a case of FLHCC in pregnancy and discuss the dilemmas in management. A 26 year-old primigravida, 26 weeks of gestation presented with a month’s history of obstructive jaundice secondary. Investigations revealed a mass in the left lateral segment of the liver with extension down the left hepatic duct into the common bile duct. Following an emergency caesarean section at 31 weeks, she underwent a left hepatectomy with extrahepatic bile duct excision. The postoperative course was uneventful. Histopathology showed FLHCC. In conclusion, liver tumors presenting during pregnancy should be managed in a multidisciplinary setup with facilities for neonatal intensive care. Management depends on the presumed pathology, period of gestation and family preferences.