Serum Levels of MMP9 and MMP2 in Patients with Oral Squamous Cell Carcinoma

Lotfi, Alireza,Mohammadi, Ghodrat,Tavassoli, Atena,mousaviagdas, Mehrnoosh,Chavoshi, Hadi,Saniee, Lale Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4

Background: Squamous cell carcinoma (SCC) is the most common cancer in the oral area. Matrix metalloproteinases (MMPs) and especially MMP-2 and MMP-9 are increased in malignancy and lymph node involvement in oral SCCs. We aimed to evaluate the serum levels of MMP-2 and MMP-9 in patients with oral SCC compared to normal subjects and their relation with clinicopathological findings. Materials and Methods: In this case control study, 20 patients with oral SCC and 20 healthy subjects were included and serum levels of MMP-2 and MMP-9 were compared between groups. Also, the correlation between these markers with clinicopathological findings including grade (T) and node (N) were evaluated. Results: Patients with oral SCC had significantly higher serum levels of MMP-2 (p=0.01) and MMP-9 (p<0.001) compared to healthy subjects. With increase in grade T, MMP-2 was significantly increased (p=0.001), but in the MMP-9 case this was not significant (p=0.27). The levels of MMP-2 (p=0.002) and MMP-9 (p=0.01) in cases with lymph node involvement and that of MMP-2 in subjects with smoking history (p=0.001) were significantly high. There was significantly positive correlation between MMP-2 with grade T tumor (r=0.598, p=0.005), lymph node involvement (r=0.737, p<0.001) and smoking (r=0.674, p=0.001) and also between MMP-9 and lymph node involvement (r=0.474, p=0.03). Conclusions: Both markers are significantly increased in oral SCC compared to healthy subjects. However, MMP-2 was better for evaluating lymph node involvement and tumor grade.

Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance

Lotfi, Alireza,Mohammadi, Ghodrat,Saniee, Lale,Mousaviagdas, Mehrnoosh,Chavoshi, Hadi,Tavassoli, Atena Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Background: Laryngeal cancer is an important malignancy in head and neck area and squamous cell carcinoma (SCC) is the most common type accounting for 95% of cases. Increase in matrix metalloproteinases (MMPs) in different tumors and their correlation with tumor invasiveness has been documented. However, most studies have evaluated MMP-2 and MMP-9 expression and few have evaluated serum levels. The aim of current study was to evaluate serum levels in patients with laryngeal SCC compared to normal subjects and assess any relation with tumor clinicopathological findings. Materials and Methods: In this case control study, 20 patients with oral SCC and 20 healthy subjects were included. Serum levels of MMP-2 and MMP-9 were compared between groups and correlations with findings including grade (T) and node involvement (N) were evaluated. Results: Patients with laryngeal SCC had significantly higher serum levels of MMP-2 (p=0.01) and MMP-9 (p=0.03) compared to healthy subjects. Patients with higher T stage (T3,4) had significantly higher MMP-2 (p=0.04) and MMP-9 (p=0.01). There was significant positive correlation between serum levels of MMP-2 with T stage (r=0.45, p=0.04) and lymph node involvement (r=0.563, p=0.01) and between levels of MMP-9 with T stage (r=0.527, p=0.01). Conclusions: Our results showed that compared to healthy subjects, both MMP-2 and MMP-9 are significantly increased in serum of laryngeal SCC cases. MMP-2 was correlated with lymph node involvement while MMP-9 has stronger correlation with T stage compared to MMP-2.

Recent advances in generalized thermoelasticity theory and the modified models: a review

Farshad Shakeriaski,Maryam Ghodrat,Juan Escobedo-Diaz,Masud Behnia 한국CDE학회 2021 Journal of computational design and engineering Vol.8 No.1

A review of the recent studies on the generalized thermoelasticity theories and their associated modified models is presented. The aim is to outline an overview of the utilization and physical limitations of available relevant theories. By contrast to classical thermoelasticity theory, generalized thermoelasticity theories (second sound) can involve a hyperbolic-form transport correlation and are motivated by experiments illustrating more accurately of the wave-form heat transfer (second sound). Many researchers have formulated such theories on different fields and analyzed various problems, presenting characteristic properties of these theories. This paper expresses a self-included bibliographical review of previous documents in the area of the second sound. The general structure of this review contains theories, formulations, real limitations, and used solution techniques of the equations for different geometries and loadings. Given that the classical theory is feeble in simulating the temperature distribution, especially in the structures under a sudden thermal shock, this review may be a useful tool for researchers who work in sensitive industries such as steam turbines, micro-temperature sensors, and lithium battery manufacturing.

Modified Green–Lindsay thermoelasticity wave propagation in elastic materials under thermal shocks

Farshad Shakeriaski,Maryam Ghodrat,Juan Escobedo-Diaz,Masud Behnia 한국CDE학회 2021 Journal of computational design and engineering Vol.8 No.1

In this study, a nonlinear numerical method is presented to solve the governing equations of generalized thermoelasticity in a large deformation domain of an elastic medium subjected to thermal shock. The main focus of the study is on the modified Green–Lindsay thermoelasticity theory, solving strain and temperature rate-dependent model using finite strain theory. To warrant the continuity of the finding responses at the boundary after the applied shock, higher order elements are adopted. An analytical solution is provided to validate the numerical findings and an acceptable agreement between the two presented solutions is obtained. The findings revealed that stress and thermal waves have distinct interactions and a harmonic temperature variation may lead to a systematic uniform stress distribution. Besides, a notable difference in the results predicted by the modified Green–Lindsay model and classic theory is observed. It is also found that the modified Green–Lindsay theory is more efficient in determining the wave propagation phenomenon. Furthermore, the findings established that thermal shock induces tensile stresses in the structure immediately after the shock, and the perceived phenomenon mainly depends on the defined boundary conditions. The results show that the strain rate can have a significant influence on the displacement and stress wave propagation in a structure subjected to thermal shock and these impacts may be more considerable with mechanical loading.

Consolidation deformation of Baghmisheh marls of Tabriz, Iran

Jalali-Milani, Shahrokh,Asghari-Kaljahi, Ebrahim,Barzegari, Ghodrat,Hajialilue-Bonab, Masoud Techno-Press 2017 Geomechanics & engineering Vol.12 No.4

Vast parts of the east of Tabriz city have been covered by Baghmisheh formation marls. These marls can be classified into three types based on their color as identified in yellow, green, and gray marls. Many high-rise buildings and other projects were founded and now is constructing on these marls. Baghmisheh formation marls are classified as stiff soil to very weak rock, therefore they undergo considerable consolidation settlement under foundation loads. This study presents the physical properties and consolidation behavior of these marls. According to the XRD tests, major clay minerals of marls are Illite, Kaolinite, Montmorillonite and Chloride. Uniaxial compressive strength are 100-250, 300-480 and 500-560 kPa for yellow, green and gray marls, respectively. Consolidation and creep behavior of Baghmisheh marls investigated by using of one dimensional consolidation apparatus under stress level up to 5 MPa. The results indicate that yellow marls have high compressibility, settlement and deformation modules. Green marls have an intermediate compressibility and settlement and while gray marls have low compressibility and settlement and from the foundation point of view have high stability. According to the creep test results, all types of marls have not been entered to progressive creep phase up to pressure 5 MPa.

Estimation of Genetic Parameters of Body Weight Traits in Ghezel Sheep

Baneh, Hasan,Hafezian, Seyed Hasan,Rashidi, Amir,Gholizadeh, Mohsen,Rahimi, Ghodrat Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.2

The present study was carried out to estimate genetic parameters for body weight traits in Ghezel sheep. The data set used was records of 9,221 lambs from 180 sires and 5,060 dams for birth weight (BW), 7,206 lambs from 167 sires and 4,497 dams for weaning weight (WW) and 6,112 lambs from 157 sires and 3,841 dams for 6-months weight (6 MW), which were collected from 1999 to 2007 (9-years) at Ghezel sheep Breeding Station in west Azarbaijan. Variance components and corresponding genetic parameters were obtained with univariate analyses fitting animal models using restricted maximum likelihood (REML) methods. The most suitable model for each trait was determined based on log likelihood ratio tests. Birth year, lamb gender, type of birth, age of dam and herd were significant sources of variation on BW, WW and 6 MW (p<0.01). Direct estimate of heritability for BW, WW and 6 MW was 0.24, 0.29 and 0.37, respectively. The estimate of maternal permanent environmental variance as a proportion of phenotypic variance was 0.09 and 0.05 for BW and WW, respectively. The results of this study showed that genetic progress for growth traits is possible by selection.

Modeling and fuzzy control of the engine coolant conditioning system in an IC engine test bed

Seyed Saeid Mohtasebi,Farzad A. Shirazi,Ahmad Javaheri,Ghodrat Hamze Nava 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.11

Mechanical and thermodynamical performance of internal combustion engines is significantly affected by the engine working temperature. In an engine test bed, the internal combustion engines are tested in different operating conditions using a dynamometer. It is required that the engine temperature be controlled precisely, particularly in transient states. This precise control can be achieved by an engine coolant conditioning system mainly consisting of a heat exchanger, a control valve, and a controller. In this study, constitutive equations of the system are derived first. These differential equations show the second- order nonlinear time-varying dynamics of the system. The model is validated with the experimental data providing satisfactory results. After presenting the dynamic equations of the system, a fuzzy controller is designed based on our prior knowledge of the system. The fuzzy rules and the membership functions are derived by a trial and error and heuristic method. Because of the nonlinear nature of the system the fuzzy rules are set to satisfy the requirements of the temperature control for different operating conditions of the engine. The performance of the fuzzy controller is compared with a PI one for different transient conditions. The results of the simulation show the better performance of the fuzzy controller. The main advantages of the fuzzy controller are the shorter settling time, smaller overshoot, and improved performance especially in the transient states of the system.