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        Non-digestible oligosaccharides-based prebiotics to ameliorate obesity: Overview of experimental evidence and future perspectives

        G. Divyashri,Pothiyappan Karthik,T. P. Krishna Murthy,Dey Priyadarshini,Kakarla Raghava Reddy,Anjanapura V. Raghu,Vinoth Kumar Vaidyanathan 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.14

        The diverse populations reportedly suffer from obesity on a global scale, and inconclusive evidence has indicated that both environmental and genetic factors are associated with obesity development. Therefore, a need exists to examine potential therapeutic or prophylactic molecules for obesity treatment. Prebiotics with non-digestible oligosaccharides (NDOs) have the potential to treat obesity. A limited number of prebiotic NDOs have demonstrated their ability as a convincing therapeutic solution to encounter obesity through various mechanisms, viz., stimulating beneficial microorganisms, reducing the population of pathogenic microorganisms, and also improving lipid metabolism and glucose homeostasis. NDOs include pectic-oligosaccharides, fructo-oligosaccharides, xylo-oligosaccharides, isomalto-oligosaccharides, manno-oligosaccharides and other oligosaccharides which significantly influence the overall human health by different mechanisms. This review provides the treatment of obesity benefits by incorporating these prebiotic NDOs, according to established scientific research, which shows their good effects extend beyond the colon.

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        Tensile and fracture characterization using a simplified digital image correlation test set-up

        Abhishek Kumar,S. Vishnuvardhan,A. Rama Chandra Murthy,G. Raghava 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.69 No.4

        Digital image correlation (DIC) is now a popular and extensively used full-field metrology technique. In general, DIC is performed by using a turnkey solution offered by various manufacturers of DIC. In this paper, a simple and economical set-up for DIC is proposed which uses easily accessible digital single-lens reflex (DSLR) camera rather than industrial couple-charged device (CCD) cameras. The paper gives a description of aspects of carrying a DIC experiment which includes experimental set-up, specimen preparation, image acquisition and analysis. The details provided here will be helpful to carry DIC experiments without specialized DIC testing rig. To validate the responses obtained from proposed DIC set-up, tension and fatigue tests on specimens made of IS 2062 Gr. E300 steel are determined. Tensile parameters for a flat specimen and stress intensity factor for an eccentrically-loaded single edge notch tension specimen are evaluated from results of DIC experiment. Results obtained from proposed DIC experiments are compared with those obtained from conventional methods and are found to be in close agreement. It is also noted that the high resolution of DSLR allows the use of proposed approach for fracture characterization which could not be carried out with a typical turnkey DIC solution employing a camera of 2MP resolution.

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