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RISS 인기검색어
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- 저자 : Fuqiang Xie (검색결과 2 건)
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Yuhu Zhang,Pei Xie,Xiao Pu,Fuqiang Xia,Jialin An,Peng Wang,Qiwen Mei 한국기상학회 2019 Asia-Pacific Journal of Atmospheric Sciences Vol.55 No.2
Analyses of drought and precipitation require long-term historical data and reasonable drought index to ensure reliable monitoring and prediction, especially for the Xinjiang Uygur Autonomous Region, where is sensitive and vulnerable to drought disasters. Drought characteristic was expressed using the observational precipitation data and calculated precipitation threshold at 105 meteorological stations from 1979 to 2014. The results showed that the variation of drought and precipitation was not spatially uniform. Analysis in sub-areas was conducted based on mutli-statistical methods. The historical drought and precipitation situation in Xinjiang is better characterized by three clusters. Cluster 1 is the driest, cluster 2 has a clear increasing trend of precipitation, while cluster 3 is the wettest with the mean annual precipitation approximates to 300 mm. In addition, the precipitation concentration and distribution is becoming uniform, there is a faster rate of increasing precipitation in coolseason rather than in warm-season. The results provide critical support for the drought disasters management and mitigation, it also provide a base for in-depth investigation on the possible mechanisms of regional drought.
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Jian Huang,Di Zhang,Fuqiang Xie,Degui Lin 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.2
Increasing evidence suggests that cancer stem cells (CSCs) are responsible for tumor initiation and maintenance. Additionally, it is becoming apparent that cyclooxygenase (COX) signaling is associated with canine mammary tumor development. The goals of the present study were to investigate COX-2 expression patterns and their effect on CSC-mediated tumor initiation in primary canine mammary tissues and tumorsphere models using immunohistochemistry. Patterns of COX-2, CD44, octamer-binding transcription factor (Oct)-3/4, and epidermal growth factor receptor (EGFR) expression were examined in malignant mammary tumor (MMT) samples and analyzed in terms of clinicopathological characteristics. COX-2 and Oct-3/4 expression was higher in MMTs compared to other histological samples with heterogeneous patterns. In MMTs, COX-2 expression correlated with tumor malignancy features. Significant associations between COX-2, CD44, and EGFR were observed in low-differentiated MMTs. Comparative analysis showed that the levels of COX-2, CD44, and Oct-3/4 expression varied significantly among TSs of three histological grades. Enhanced COX-2 staining was consistently observed in TSs. Similar levels of staining intensity were found for CD44 and Oct-3/4, but EGFR expression was weak. Our findings indicate the potential role of COX-2 in CSC-mediated tumor initiation, and suggest that COX-2 inhibition may help treat canine mammary tumors by targeting CSCs.
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