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- 저자 : Fu Xiling (검색결과 2 건)
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Fu Xiling,Chang Jiabao,Jiao Damin,Zhu Mengying,Ma Yuqi 대한독성 유전단백체 학회 2024 Molecular & cellular toxicology Vol.20 No.2
Liver fibrosis is a chronic liver disease caused by a variety of pathophysiological. However, there are no effective treatments to combat it. HSCs are a major source of fibrotic cells and exploring the mechanisms of HSC activation may provide new strategies for the treatment of liver fibrosis.To explore the role and underlying mechanism of SLIT3 in HSCs fibrosis.GSE163211 dataset analysis identified aberrant expression of SLIT3 in NASH F1-F4 tissues and SLIT3 expression level was positively correlated with fibrosis-related proteins. In vitro experiments showed that TGF-β induced upregulation of SLIT3 in LX-2 cells. Knockdown of SLIT3 significantly inhibited TGF-β-induced α-SMA, COL1A2, and COL1A1 expression, inhibited excessive cell proliferation and migration, and suppressed YAP activity.Collectively, our findings suggest that SLIT3 deficiency alleviates TGF-β-induced HSCs activation by inhibiting YAP activity. Objective Liver fibrosis is a chronic liver disease caused by a variety of pathophysiological. However, there are no effective treatments to combat it. HSCs are a major source of fibrotic cells and exploring the mechanisms of HSC activation may provide new strategies for the treatment of liver fibrosis. Objectives To explore the role and underlying mechanism of SLIT3 in HSCs fibrosis. Results GSE163211 dataset analysis identified aberrant expression of SLIT3 in NASH F1-F4 tissues and SLIT3 expression level was positively correlated with fibrosis-related proteins. In vitro experiments showed that TGF-β induced upregulation of SLIT3 in LX-2 cells. Knockdown of SLIT3 significantly inhibited TGF-β-induced α-SMA, COL1A2, and COL1A1 expression, inhibited excessive cell proliferation and migration, and suppressed YAP activity. Conclusion Collectively, our findings suggest that SLIT3 deficiency alleviates TGF-β-induced HSCs activation by inhibiting YAP activity.
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RNA-seq for comparative transcript profiling in leaves of strawberry seedlings under salinity stress
Zhang Rui,Du Qiuli,Zhao Wenzhe,Yang Long,Li Dong-mei,Chen Xiude,Xiao Wei,Fu Xiling,Yang Chao,Li Ling 한국식물생명공학회 2023 Plant biotechnology reports Vol.17 No.1
As a major economic crop, strawberry (Fragaria × ananassa Duch.) has been widely planted in the world because of their adaptability and high economic efficiency. In the process of strawberry production, the traditional techniques of furrow irrigation, irrigating irrigation and water and fertilizer management are still relatively common, resulting in secondary salinization of the soil and an imbalance of nutrient ratio, resulting in a decrease in strawberry yield and quality. A total of 2334, 2718 differentially expressed genes (DEGs) were identified in the 3-day, 6-day salt-treated leaf tissues compared with the controls, respectively. Based on the analysis of DEG function annotation and enrichment, a pattern of strawberry leaves response to NaCl stress was proposed. The processes related to plant hormone signal and lipid metabolism pathway were noted in the response of strawberry leaves to NaCl. Our transcriptome data provides valuable insights into genes involved in the growing process of strawberry seedlings under salt stress, and may help in developing seedlings with enhanced responses to salt stress in the years to come.
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