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      • SCISCIESCOPUS

        Urban rainwater harvesting systems: Research, implementation and future perspectives

        Campisano, Alberto,Butler, David,Ward, Sarah,Burns, Matthew J.,Friedler, Eran,DeBusk, Kathy,Fisher-Jeffes, Lloyd N.,Ghisi, Enedir,Rahman, Ataur,Furumai, Hiroaki,Han, Mooyoung Elsevier 2017 Water research Vol.115 No.-

        <P><B>Abstract</B></P> <P>While the practice of rainwater harvesting (RWH) can be traced back millennia, the degree of its modern implementation varies greatly across the world, often with systems that do not maximize potential benefits. With a global focus, the pertinent practical, theoretical and social aspects of RWH are reviewed in order to ascertain the state of the art. Avenues for future research are also identified. A major finding is that the degree of RWH systems implementation and the technology selection are strongly influenced by economic constraints and local regulations. Moreover, despite design protocols having been set up in many countries, recommendations are still often organized only with the objective of conserving water without considering other potential benefits associated with the multiple-purpose nature of RWH. It is suggested that future work on RWH addresses three priority challenges. Firstly, more empirical data on system operation is needed to allow improved modelling by taking into account multiple objectives of RWH systems. Secondly, maintenance aspects and how they may impact the quality of collected rainwater should be explored in the future as a way to increase confidence on rainwater use. Finally, research should be devoted to the understanding of how institutional and socio-political support can be best targeted to improve system efficacy and community acceptance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A review of practical, theoretical and social aspects or urban rainwater harvesting systems. </LI> <LI> Much of the implemented systems do not consider the multi-purpose nature of RWH. </LI> <LI> Need of datasets including water saving, stormwater management and energy consumption aspects. </LI> <LI> Institutional and socio-political support to improve RWH efficacy and community acceptance. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

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        Do spontaneously decreasing estradiol levels prior to triggering of ovulation adversely impact in vitro fertilization outcomes?

        Grin, Leonti,Berkovitz-Shperling, Roza,Zohav, Eyal,Namazov, Ahmet,Leyetes, Sophia,Friedler, Shevach The Korean Society for Reproductive Medicine 2020 Clinical and Experimental Reproductive Medicine Vol.47 No.3

        Objective: The aim of this study was to explore the potential adverse effect of spontaneously decreasing serum estradiol (SE) levels on in vitro fertilization (IVF) outcomes. Methods: This retrospective single-subject study analyzed IVF cycles conducted at a hospital IVF unit between 2010 and 2017. Overall, 2,417 cycles were analyzed. Only cycles with spontaneously decreasing SE before human chorionic gonadotropin (hCG) triggering were included. Each patient served as her own control, and subsequent cycles were analyzed for recurrent SE decreases. The main outcome was the number of oocytes retrieved. Results: Cycle characteristics were similar between the study (SE decrease) and control groups, with the exception of the median SE on the day of hCG triggering (899.7 pg/mL; interquartile range [IQR], 193-2,116 pg/mL vs. 1,566.8 pg/mL; IQR, 249-2,970 pg/mL; p< 0.001). The study group, relative to the control group, had significantly fewer total oocytes (5 [IQR, 2-9] vs. 7 [IQR, 3-11]; p= 0.002) and significantly fewer metaphase II (MII) oocytes (3 [IQR, 1-6] vs. 4 [IQR, 2-8]; p= 0.001) retrieved. The study group had fewer cleavage-stage embryos than the control cycles (3 [IQR, 1-6] vs. 4 [IQR, 2-7]; p= 0.012). Compared to cycles with a ≤ 20% SE decrease, cycles with a > 20% decrease had significantly fewer total and MII oocytes retrieved. SE decrease recurred in 12% of patients. Conclusion: A spontaneous decrease in SE levels adversely affected IVF outcomes, with a linear correlation between the percentage decrease and the number of oocytes retrieved. SE decrease can repeat in later cycles.

      • Determination of the Thermodynamically Dominant Metabolic Pathways

        Yun, Choamun,Kim, Tae Yong,Zhang, Tengyan,Kim, Young,Lee, Sang Yup,Park, Sunwon,Friedler, Ferenc,Bertok, Botond American Chemical Society 2013 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.52 No.1

        <P>An effective strategy comprising two phases is proposed to determine the thermodynamically dominant pathways in a metabolic network of a given phenotype, involving several metabolic reactions. In the first phase, stoichiometrically feasible metabolic pathways are exhaustively identified through the flux balance analysis and the graph-theoretic method based on P-graphs. In the second phase, thermodynamically dominant pathways are selected from these stoichiometrically feasible metabolic pathways on the basis of the Gibbs free energy change of reaction. The proposed strategy’s efficacy is demonstrated by applying it to two <I>E. coli</I> models: one is for maximal acetate and ethanol production, and the other is for maximalpoly(3-hydroxybutyrate) production.</P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ie300652h'>ACS Electronic Supporting Info</A></P>

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