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Maria Scaturro,Stefania Meschini,Giuseppe Arancia,Fontana Stefano,Maria Luisa Ricci 한국미생물학회 2009 The journal of microbiology Vol.47 No.6
The pathogenesis of Legionella pneumophila mainly resides in its ability to inhibit the phagosome-lysosome fusion, which normally prevents the killing of the host cells. In order to characterize the molecular alterations that occurred in a spontaneous avirulent mutant of Legionella pneumophila serogroup 6, named Vir-, we investigated the ability of the mutant to adhere to and multiply in the WI26VA4 alveolar epithelial cell line and in human macrophages, when compared to its parental strain, Vir+. We also determined the co- localization of bacteria with LAMP-1 to gain an insight into the phagosome-lysosome fusion process. Additionally, we determined the flagellin expression and dotA nucleotide sequencing. We observed a lack of expression of flagellin and an in-frame mutation in the dotA gene. The data obtained strongly suggest the loss of virulence of the mutant could probably be due to the absence of flagellin and the dysfunctional type IV secretion system, resulting from the DotA protein being severely compromised.
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iPOJO-based Middleware Solutions for Self-Reconfiguration and Self-Optimization
( Paolo Bellavista ),( Antonio Corradi ),( Damiano Fontana ),( Stefano Monti ) 한국인터넷정보학회 2011 KSII Transactions on Internet and Information Syst Vol.5 No.8
In recent years, ubiquitous and pervasive scenarios have emerged as a complex ecosystem where differentiated software/hardware components interoperate wirelessly and seamlessly. The goal is to enable users to continuously access services and contents, and to always get the best out of their current environment and available resources. In such dynamic and flexible scenarios, the need emerges for flexible and general solutions for continuous runtime self-reconfiguration and self-optimization of ubiquitous support software systems. This paper proposes a fully reconfigurable middleware approach that aims at reconfiguring complex software systems made up of heterogeneous off-the-shelf components from both functional and non-functional perspectives. Our middleware can also extend already existing and non-reconfigurable middleware/applications in an easy and flexible way, with no need to re-design them. The proposed design principles have been practically applied to the implementation of a runtime self-reconfigurable middleware called Off-The-Shelf Ready To Go (OTS-RTG), implemented on top of iPOJO. The reported experimental results both exhibit a limited overhead and show the wide applicability of the proposed solution to many application scenarios, including complex, industrial, Enterprise Service Bus-based ones.
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