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Sustainable mold biomachining for the manufacturing of microfluidic devices
Arrate Santaolalla,Yara Alvarez-Braña,Astrid Barona,Lourdes Basabe-Desmonts,Fernando Benito-Lopez,Naiara Rojo 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-
Biomachining has been investigated as a sustainable and effective alternative to conventional prototypingtechniques for molding polymeric materials for their subsequent use as microfluidic devices. A noveland simple process based on the combination of a Pressure Sensitive Adhesive mask and a varnish hasbeen proposed for preparing metal workpieces as an alternative to photolithography, with the latterbeing the most widely used technique for protecting workpieces. As far as the bioprocess is concerned,it has been applied in successive mold-etching and oxidant bio-regeneration stages. Metal solubilizationhas proven to be repeatable in several consecutive mold-etching stages when using the regenerated oxidantsolution. As a result, the lifespan of the biomachining medium has been prolonged, contributing toprocess sustainability. An equation with two restrictions has been proposed to predict the time requiredto obtain a mold with a fixed height, as metal solubilization evolves differently between the first and subsequenthours. Finally, the bio-engraved copper pieces have acted as effective molds in the fabrication ofself-powered polydimethylsiloxane microfluidic devices. This new biomachining application is thereforean effective and ecofriendly process for producing microfluidic devices.
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