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- 저자 : Faramarz Edalat (검색결과 1 건)
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차재민,황유식,배호재,Nasser Sadr,Sam Manoucheri,Faramarz Edalat,김기영,김상복,권일근,ALI KHADEMHOSSEINI 한국고분자학회 2015 Macromolecular Research Vol.23 No.3
Embryoid bodies have a number of similarities with cells in gastrulation, which provides useful biologicalinformation about embryonic stem cell differentiation. Extensive research has been done to study the control ofembryoid body-mediated embryonic stem cell differentiation in various research fields. Recently, microengineeringtechnology has been used to control the size of embryoid bodies and to direct lineage specific differentiation ofembryonic stem cells. However, the underlying biology of developmental events in the embryoid bodies of differentsizes has not been well elucidated. In this study, embryoid bodies with different sizes were generated within microfabricatedPEG microwell arrays, and a series of gene and molecular expressions related to early developmentalevents was investigated to further elucidate the size-mediated differentiation. The gene and molecular expressionprofile suggested preferential visceral endoderm formation in 450 μm embryoid bodies and preferential lateral platemesoderm formation in 150 μm embryoid bodies. These aggregates resulted in higher cardiac differentiation in 450 μmembryoid bodies and higher endothelial differentiation in 150 μm embryoid bodies, respectively. Our findings mayprovide further insight for understanding embryoid body size-mediated developmental progress.
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