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RISS 인기검색어
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- 저자 : Eve Bralley (검색결과 2 건)
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Inhibition of Hyaluronidase Activity by Select Sorghum Brans
Eve Bralley,Phillip Greenspan,James L. Hargrove,Diane K. Hartle 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.2
Hyaluronidase hydrolyzes glycosaminoglycans, including hyaluronan, in the extracellular matrix during tissueremodeling. Hyaluronidase activity increases in chronic inflammatory conditions, e.g., inflammatory joint disease. In thisstudy, we tested the ability of ethanolic extracts (1:9 [wt/vol] of 50% ethanol) of bran from six cultivated varieties of Sorghumbicolor to inhibit hyaluronidase activity in vitroin comparison to extracts of wheat and rice bran. Each extract inhibitedhyaluronidase activity with this order of potency: Sumac. Shanqui Red. Black. Mycogen. Fontanelle. Whitesorghum. Extracts of wheat and rice bran had weak inhibitory activities relative to the high phenolic sorghum brans.Hyaluronidase inhibition correlated positively with total phenolic content and ferric reducing antioxidant power values foreach bran extract. Inhibition was not only due to condensed tannins (proanthocyanidins) because the Black sorghum cultivarlacks condensed tannins but has abundant anthocyanins and other polyphenols. Since hyaluronidase activity is important inconditions such as osteoarthritis and skin aging, these sorghum varieties deserve consideration for functional foods and bev-erages, and for nutraceutical and cosmeceutical ingredients.
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James L. Hargrove,Eve E. Bralley,Phillip Greenspan,Diane K. Hartle 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.4
The ability of muscadine grape skin, seed, or combined skin and seed extracts to inhibit mouse ear inflam-mation, edema, and polymorphonuclear leukocyte infiltration was tested following topical application of 12-O-tetrade-canoylphorbol 13-acetate (TPA). Ethanolic extracts of skins, seeds, or a combination of these from purple (Ison) cultivarswere applied to both ears of female Swiss mice 30 minutes after TPA (2 .g per ear) administration. Control mice were treatedwith indomethacin or 50% ethanol vehicle 30 minutes after TPA. Ear thickness was measured before TPA and at 4 and 24marker of edema. Myeloperoxidase (MPO) (EC 1.11.1.7) activity was measured in each ear punch biopsy as an index of neu-trophil infiltration. Extracts of muscadine skin, seed, and combination treatments significantly reduced ear edema, ear biopsyweight, and MPO activity compared to TPA vehicle control. There was no significant difference in anti-inflammatory activ-ity of the skin and seed extracts. However, an additive effect was observed with the combination treatment that was statisti-cally similar to the anti-inflammatory activity of indomethacin treatment. It can be concluded that muscadine skin, seed, andcombination skin/seed extracts exhibit significant topical anti-inflammatory properties.
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