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RISS 인기검색어
- 검색키워드
- 저자 : Dongkai Jia (검색결과 3 건)
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Effect of convex surface splicing characteristics of mold on the machining error in milling process
Dongkai Jia,Shi Wu,Chunfeng Wang,Xian-li Liu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.1
Most of the molds of automobile panels are spliced with insert-type modules. Sudden variations in load and impact vibration can occur while processing splicing area, which affects the overall quality of this area. In this study, to improve the machining accuracy of the convex-surface splicing area, the influence of thermal deformation of tool, residual height, and impact vibrations on the machining error of this area is firstly analyzed. Subsequently, based on the motion path of the cutting edge of ball-end mill, a comprehensive error model for mill machine is established, which accounts for the tool error, residual height, and milling vibration. Finally, based on the milling experiment of convex-surface splicing die, the variation trend of machining error with machining inclination, spindle speed, and cutting depth is examined to verify comprehensive error algorithm MATLAB simulation results. The experimental results show that the prediction error of the proposed error model is between 4-8 % when the machining inclination is positive, and it is between 18-21 % when the machining inclination is negative, indicating that the proposed model is consistent with the experimental data. Novelty aspects, the present work: (i) proposes a mechanistic modeling approach to predicting machining error considering of thermal deformation, residual height, and impact vibrations for splicing mold; (ii) demonstrates that thermal deformation, residual height, and impact vibrations need to be taken into account for modeling the comprehensive machining error of splicing mold; (iii) contributes to practical industrial application of finishing machining technology of mold and die with splicing characteristics.
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Role of silibinin in the management of diabetes mellitus and its complications
Chun Chu,Da-Hong Li,Shicheng Zhang,Takashi Ikejima,Ying Jia,Dongkai Wang,Fanxing Xu 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.8
Diabetes mellitus is globally approaching epidemicproportions and acts as a major cause of a number ofserious health problems diagnosed as diabetic complications. The current oral drugs in the treatment of diabetesand its complications could meet some but not all of thepatients’ needs, and the development of novel drugs with ahypoglycemic effect is urgently required. Silibinin, aflavonolignan traditionally used for the treatment of gallbladderand hepatic diseases, was reported to improveglycemic homeostasis by improving the activity of pancreaticb-cells, increasing insulin sensitivity of liver andmuscle cells, and decreasing lipid deposition in adipocytes. Researches also indicated the effectiveness of silibinin incontrolling several diabetic complications including neuropathy,retinopathy, impaired healing, hepatopathy, cardiomyopathy,nephropathy, and osteoporosis. In thisreview, we summarize the recent anti-diabetes findings ofsilibinin and clarify the underlying pharmacologicalmechanisms, and update the knowledge in understandingthe role of silibinin in control of diabetic complications.
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( Chun Chu ),( Xiang Gao ),( Xiang Li ),( Xiaoying Zhang ),( Ruixin Ma ),( Ying Jia ),( Dahong Li ),( Dongkai Wang ),( Fanxing Xu ) 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.2
Silibinin exhibits antidiabetic potential by preserving the mass and function of pancreatic β-cells through up-regulation of estrogen receptor-α (ERα) expression. However, the underlying protective mechanism of silibinin in pancreatic β-cells is still unclear. In the current study, we sought to determine whether ERα acts as the target of silibinin for the modulation of antioxidative response in pancreatic β-cells under high glucose and high fat conditions. Our in vivo study revealed that a 4-week oral administration of silibinin (100 mg/kg/day) decreased fasting blood glucose with a concurrent increase in levels of serum insulin in high-fat diet/streptozotocin- induced type 2 diabetic rats. Moreover, expression of ERα, NF-E2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) in pancreatic β-cells in pancreatic islets was increased by silibinin treatment. Accordingly, silibinin (10 μM) elevated viability, insulin biosynthesis, and insulin secretion of high glucose/palmitate-treated INS-1 cells accompanied by increased expression of ERα, Nrf2, and HO-1 as well as decreased reactive oxygen species production in vitro. Treatment using an ERα antagonist (MPP) in INS-1 cells or silencing ERα expression in INS-1 and NIT-1 cells with siRNA abolished the protective effects of silibinin. Our study suggests that silibinin activates the Nrf2-antioxidative pathways in pancreatic β-cells through regulation of ERα expression.
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