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RISS 인기검색어
- 검색키워드
- 저자 : David W.A. Bourne (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Kwon, Kwang-Il,Bourne, David-W.A. The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.3
A Physiologically based pharmacokinetic model was used to describe the distribition and elimination of cefriazone in the rat. To validate the practical application of the model, the effect of cffeine on the model was also examined. The model consisted of eleven compartments representing the major sites for ceftriaxone distribution including carcass which served as a residual compartment. Elimination was represented by renal and hepatic (metabolic biliary )excretion with GI secretion and re-absorption. The drug concentrations in most of the tissues were simulated using flow limited equations while brain levels were simulated using membrane limited passive diffusion distribution. The experimental data were obtained by averaging the concentration of drug in the plasma and tissues of five rats after i. v. injection of cefriazone 100 mg/kg without and with caffeine 20 mg/kg. The data for the amount of ceftriazone excreted in urine and gut contents were used to apportion total body clearance. HPLC with UV detection was used for the assay with 0.1-0.2 $\mu$g/ml sensitivity. The great majority of drug concentrations with and without caffeine show reasonably good agreements to the simulation results within 20%. The effect of caffeine on renal and hepatic clearances was apparent with 18.8% and 18.6% increase in the model values, respectively.
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Kwon, Kwang-Il,David W.A. Bourne 충남대학교 약학대학 의약품개발연구소 1990 藥學論文集 Vol.6 No.-
A Physiologically based pharmacokinetic model was used to describe the distribution and elimination of ceftriaxone in the rat. To validate the practical application of the model the effect of caffeine on the model was also examined. The model consisted of eleven compartments representing the major sites for ceftriaxone distribution including carcass which served as a residual compartment. Elimination was represented by renal and hepatic (metabolic biliary) excretion with GI secretion and re-absorption. The drug concentrations in most of the tissues were simulated using flow limited equations while brain levels were simulated using membrane limited passive diffusion distribution. The experimental data were obtained by averaging the concentration of drug in the plasma and tissues of five rats after i.v. injection of ceftriaxone 100 ㎎/㎏ without and with caffeine 20 ㎎/㎏. The data for the amount of ceftriaxone excreted in urine and gut contents were used to apportion total body clearance. HPLC with UV detection was used for the assay with 0.1-0.2 ㎍/㎖ sensitivity. The great majority of drug concentrations with and withour caffeine show reasonably good agreements to the simulation results within 20%. The effect of caffeine on renal and hepatic clearances was apparent with 18.8% and 18.6% increase in the model values, respectively.
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Gastrointestinal Absorption of Phenytoin from an Oil-in-water Microemulsion
Kwon, Kwang-il,Bourne, David W.A. 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-
The absorption profile of phenytoin Na emulsion were examined compared to that of phenytion suspension after oral administration in the rat. The corn oil-in-water emulsion, particle size of 184±57.8㎚, was prepared using a microfludizer, and phenytoin Na added by shaft homogenizer. The phenytoin emulsion or suspension, 100 ㎎/㎏, were intubated intragastrically using oral dosing needle and blood samples were withdrawn via an indwelling cannula from the conscious rat. Plasma concentrations of phenytoin were measured with HPLC using phenacetin as an internal standard. The plasma concentration versus time data were fitted to a one compartment open model and the pharmacokinetic parameters were calculated using the computer program, Boomer. The phenytoin plasma concentrations from the emulsion at each observed time were about 1.5-2 times higher than those from the suspenson, significantly at time of 5, 6 and 7 hr after administration. The absorption (K_a) and elimination rate constant (k_e) were not altered significantly, however the AUC increased from 65.6 to 106.7 ㎍ㆍhr/㎖ after phenytoin suspension or emulsion oral administration, repectively. From an equilibrium dialysis study, the diffusion rate constant (k_IE) was considerably higher from the phenytoin Na emulsion (0.0439 hr) than phenytoin suspension (0.0014 hr^-1).
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Gastrointestinal Absorption of Phenytoin from on Oil-in-water Microemulsion
Kwon, Kwang-Il,Bourne, David-W.A. The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.5
The absorption profile of phenytoin Na emulsion were examined compared to that of phenytoin suspension after oral administration in the rat. The corn oil-in-water emulsion, particle size of $184{\pm}$57.8 nm, was prepared using a microfludizer, and phenytoin Na added by shaft homogenizer. The phenytoin emulsion or suspension, 100 mg/kg, were intubated intragastrically using oral dosing needle and blood samples were withdrawn via an indwelling cannula from the conscious rat. Plasma concentrations of phenytoin were measured with HPLC using phenacetin as an internal standard. The plasma concentration versus time data were fitted to a one compartment open model and the pharmacokinetic parameters were calculated using the computer program, Boomer. The phenytoin plasma concentrations from the emulsion at each observed time were about 1.5-2 times higher than those from the suspension, significantly at time of 5, 6 and 7 hr after administration. The absorption $(k_a)$ and elimination rate constant $(k_e)$ were not altered significantly, however the AUC increased from 65.6 to $106.7{\mu}ghr/ml$ after phenytoin suspension or emulsion oral administration, respectively. From an equilibrium dialysis study, the diffusion rate constant $(k_{IE})$ was considerably higher from the phenytoin Na emulsion $(0.0439 hr{-1})$ than phenytoin suspension $(0.0014 hr{-1})$.
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