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Cilostazol ameliorates diabetic nephropathy by inhibiting highglucose-induced apoptosis
Chien-Wen Chian,Yung-Shu Lee,Yi-Ju Lee,Ya-Hui Chen,Chi-Ping Wang,Wen-Chin Lee,Huei-Jane Lee 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.5
Diabetic nephropathy (DN) is a hyperglycemia-induced progressive development of renal insufficiency. Excessive glucose can increase mitochondrial reactive oxygen species (ROS) and induce cell damage, causing mitochondrial dysfunction. Our previous study indicated that cilostazol (CTZ) can reduce ROS levels and decelerate DN progression in streptozotocin (STZ)-induced type 1 diabetes. This study investigated the potential mechanisms of CTZ in rats with DN and in high glucose-treated mesangial cells. Male Sprague-Dawley rats were fed 5 mg/kg/day of CTZ after developing STZ-induced diabetes mellitus. Electron microscopy revealed that CTZ reduced the thickness of the glomerular basement membrane and improved mitochondrial morphology in mesangial cells of diabetic kidney. CTZ treatment reduced excessive kidney mitochondrial DNA copy numbers induced by hyperglycemia and interacted with the intrinsic pathway for regulating cell apoptosis as an antiapoptotic mechanism. In high-glucose-treated mesangial cells, CTZ reduced ROS production, altered the apoptotic status, and down-regulated transforming growth factor beta (TGF-β) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB). Base on the results of our previous and current studies, CTZ deceleration of hyperglycemia-induced DN is attributable to ROS reduction and thereby maintenance of the mitochondrial function and reduction in TGF-β and NF-κB levels.
Carbon black sintering effects on the composition of multiphase calcium phosphate bioceramics
Wen-Cheng Chen,Chien-Ping Ju,Wen-Hsien Cheng,Jiin-Huey Chern Lin 한양대학교 세라믹연구소 2013 Journal of Ceramic Processing Research Vol.14 No.3
The presence of carbonate (CO3 2-) combined with calcium phosphates has been believed to increase the susceptibility of natural bone formation. This study was carried out to investigate the thermal properties of apatite in nano scale precipitates with added carbon black that could act as a sintering inhibitor and a carbonate preserver. In addition, the present study aimed to determine the effects of those additives and analyze their chemical compositions. Ceramics processed at different heating temperatures were compared and characterized. The results showed that a multiphase ceramic of apatite-calcium carbonate (CaCO3)-calcium oxide (CaO) was formed in a temperature range of 600 to 800 ο C. By observing the morphologies of the ceramics, the addition of carbon black which acts as a carbonate supplier in the heating processes and further as an inhibitor to prevent the sintering effect of the nano scale particles in sub-micro range efficiently at 1400 ο C were established.