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        Transparent conducting oxide glass grown with TiO2-nanotube array for dye-sensitized solar cell

        Chen-Hon Chen,Keh-Chang Chen,Ju-Liang He 한국물리학회 2010 Current Applied Physics Vol.10 No.2

        An arc ion plating (AIP) deposition system was employed to produce metal titanium layer on transparent conducting oxide glass, and followed by anodically oxidizing to form a TiO2-nanotube array electrode. A dye-sensitized solar cell (DSC) was then assembled as ITO glass/[TiO2-nanotube (N3 dye)]/I2 + LiI electrolyte/Pt/ITO glass. Anodizing bath composition was varied, and post-annealing was carried out. Consequent changes in the TiO2-nanotube array microstructure and photovoltaic efficiency of the assembled DSC device were revealed. Experimental results show that a 5-lm thick metal titanium layer can be obtained after 45 min AIP deposition. The metal titanium layer underwent complete conversion into XRD-amorphous TiO2-nanotube array after anodic oxidation for 2 h. The tube can reach 10.7 ㎛ long with tube inner diameter 92 nm. The ammonium fluoride in the anodizing bath accelerates the tube growth rate. Thermal annealing at temperatures over 250 ℃ works best on anatase crystallization of the TiO2-nanotube. An ultimate photovoltaic efficiency 1.88% (active area 1 ㎠) of the assembled DSC device can be obtained for the TiO2-nanotube grown ITO glass annealed at 350 ℃.

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        Indicator Elimination for Locally Adaptive Scheme Using Data Hiding Technique

        ( Hon-hang Chang ),( Yung-chen Chou ),( Timothy K. Shih ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.12

        Image compression is a popular research issue that focuses on the problems of reducing the size of multimedia files. Vector Quantization (VQ) is a well-known lossy compression method which can significantly reduce the size of a digital image while maintaining acceptable visual quality. A locally adaptive scheme (LAS) was proposed to improve the compression rate of VQ in 1997. However, a LAS needs extra indicators to indicate the sources, consequently the compression rate of LAS will be affected. In this paper, we propose a novel method to eliminate the LAS indicators and so improve the compression rate. The proposed method uses the concept of data hiding to conceal the indicators, thus further improving the compression rate of LAS. From experimental results, it is clearly demonstrated that the proposed method can actually eliminate the extra indicators while successfully improving the compression rate of the LAS.

      • KCI등재

        Clinical Outcomes and Cost-Effectiveness of Osteoporosis Screening With Dual-Energy X-ray Absorptiometry

        Hsu Chiao-Lin,Wu Pin-Chieh,Yin Chun-Hao,Chen Chung-Hwan,Lee King-Teh,Lin Chih-Lung,Shi Hon-Yi 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.12

        Objective: This study aimed to evaluate the clinical outcomes and cost-effectiveness of dual-energy X-ray absorptiometry (DXA) for osteoporosis screening. Materials and Methods: Eligible patients who had and had not undergone DXA screening were identified from among those aged 50 years or older at Kaohsiung Veterans General Hospital, Taiwan. Age, sex, screening year (index year), and Charlson comorbidity index of the DXA and non-DXA groups were matched using inverse probability of treatment weighting (IPTW) for propensity score analysis. For cost-effectiveness analysis, a societal perspective, 1-year cycle length, 20-year time horizon, and discount rate of 2% per year for both effectiveness and costs were adopted in the incremental cost-effectiveness (ICER) model. Results: The outcome analysis included 10337 patients (female:male, 63.8%:36.2%) who were screened for osteoporosis in southern Taiwan between January 1, 2012, and December 31, 2021. The DXA group had significantly better outcomes than the non-DXA group in terms of fragility fractures (7.6% vs. 12.5%, P < 0.001) and mortality (0.6% vs. 4.3%, P < 0.001). The DXA screening strategy gained an ICER of US$ -2794 per quality-adjusted life year (QALY) relative to the non-DXA at the willingness-to-pay threshold of US$ 33004 (Taiwan’s per capita gross domestic product). The ICER after stratifying by ages of 50–59, 60–69, 70–79, and ≥ 80 years were US$ -17815, US$ -26862, US$ -28981, and US$ -34816 per QALY, respectively. Conclusion: Using DXA to screen adults aged 50 years or older for osteoporosis resulted in a reduced incidence of fragility fractures, lower mortality rate, and reduced total costs. Screening for osteoporosis is a cost-saving strategy and its effectiveness increases with age. However, caution is needed when generalizing these cost-effectiveness results to all older populations because the study population consisted mainly of women.

      • Analysis of the Genome and Transcriptome of <i>Cryptococcus neoformans</i> var. <i>grubii</i> Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation

        Janbon, Guilhem,Ormerod, Kate L.,Paulet, Damien,Byrnes III, Edmond J.,Yadav, Vikas,Chatterjee, Gautam,Mullapudi, Nandita,Hon, Chung-Chau,Billmyre, R. Blake,Brunel, Franç,ois,Bahn, Yong-Sun,Chen, Public Library of Science 2014 PLoS genetics Vol.10 No.4

        <▼1><P><I>Cryptococcus neoformans</I> is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. <I>grubii</I> and <I>neoformans</I>, respectively). Here, we sequenced the genome and performed an RNA-Seq-based analysis of the <I>C. neoformans</I> var. <I>grubii</I> transcriptome structure. We determined the chromosomal locations, analyzed the sequence/structural features of the centromeres, and identified origins of replication. The genome was annotated based on automated and manual curation. More than 40,000 introns populating more than 99% of the expressed genes were identified. Although most of these introns are located in the coding DNA sequences (CDS), over 2,000 introns in the untranslated regions (UTRs) were also identified. Poly(A)-containing reads were employed to locate the polyadenylation sites of more than 80% of the genes. Examination of the sequences around these sites revealed a new poly(A)-site-associated motif (AUGHAH). In addition, 1,197 miscRNAs were identified. These miscRNAs can be spliced and/or polyadenylated, but do not appear to have obvious coding capacities. Finally, this genome sequence enabled a comparative analysis of strain H99 variants obtained after laboratory passage. The spectrum of mutations identified provides insights into the genetics underlying the micro-evolution of a laboratory strain, and identifies mutations involved in stress responses, mating efficiency, and virulence.</P></▼1><▼2><P><B>Author Summary</B></P><P><I>Cryptococcus neoformans</I> var. <I>grubii</I> is a major human pathogen responsible for deadly meningoencephalitis in immunocompromised patients. Here, we report the sequencing and annotation of its genome. Evidence for extensive intron splicing, antisense transcription, non-coding RNAs, and alternative polyadenylation indicates the potential for highly intricate regulation of gene expression in this opportunistic pathogen. In addition, detailed molecular, genetic, and genomic studies were performed to characterize structural features of the genome, including centromeres and origins of replication. Finally, the phenotypic and genome re-sequencing analysis of a collection of isolates of the reference H99 strain resulting from laboratory passage revealed that microevolutionary processes during <I>in vitro</I> culturing of pathogenic fungi can impact virulence.</P></▼2>

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