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자궁근 cGMP 형성에 대한 융모막의 역할과 산모 및 태아혈청의 그 억제효과
김해중,Carl P. Weiner 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.5
The mechanism of uterine quiescence during pregnancy and initiation of labor is unknown. In previous report, we demonstrated myometrial cGMP rises dramatically during pregnancy and then declines just prior to the onset of labor. Further, pregnancy decrease myometrial soluble guanylate cyclase activity while enhancing particulate activity. Theses findings suggest a natriureitc peptide(NP) is responsible for the increase in cGMP. This study was undertaken to evaluate the source of that NP. We incubated myometrium from term guinea pigs in oxygenated buffer in the absence/presence of either amnionic membranes(AM, 400mg), chorionic membrane(CM, 400mg), fetal guinea pig plasma(FP, 1ml), maternal guinea pig plasama(MP, 1ml), or a combination. After incubation, cGMP(mol/mg portein) was measured by radioimmuno assay. Both AM and CM(CM$gt;AM, significantly) increased myometrial cGMP. The stimulation of myometrial cGMP by the CM has a significant linear relationship between fetal weight and the greatest cGMP increase occurred between 51~60 days after which it showed a trend to decrease. Both FP and MP decrease myometrial cGMP and inhibition of cGMP by MP increase significantly with advancing gestational age. Our date indicate that myometrial cGMP is stimulated by a compound produced by the CM and the action of this compound is inhibited by a substance produced by the mother and fetus at the end of a normal pregnancy.