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Burnout and Workload Among Health Care Workers: The Moderating Role of Job Control
Igor Portoghese,Maura Galletta,Rosa Cristina Coppola,Gabriele Finco,Marcello Campagna 한국산업안전보건공단 산업안전보건연구원 2014 Safety and health at work Vol.5 No.3
Background: As health care workers face a wide range of psychosocial stressors, they are at a high risk ofdeveloping burnout syndrome, which in turn may affect hospital outcomes such as the quality and safetyof provided care. The purpose of the present study was to investigate the moderating effect of job controlon the relationship between workload and burnout. Methods: A total of 352 hospital workers from five Italian public hospitals completed a self-administeredquestionnaire that was used to measure exhaustion, cynicism, job control, and workload. Data werecollected in 2013. Results: In contrast to previous studies, the results of this study supported the moderation effect of jobcontrol on the relationship between workload and exhaustion. Furthermore, the results found supportfor the sequential link from exhaustion to cynicism. Conclusion: This study showed the importance for hospital managers to carry out management practicesthat promote job control and provide employees with job resources, in order to reduce the burnout risk.
Burnout and Workload Among Health Care Workers: The Moderating Role of Job Control
Portoghese, Igor,Galletta, Maura,Coppola, Rosa Cristina,Finco, Gabriele,Campagna, Marcello Occupational Safety and Health Research Institute 2014 Safety and health at work Vol.5 No.3
Background: As health care workers face a wide range of psychosocial stressors, they are at a high risk of developing burnout syndrome, which in turn may affect hospital outcomes such as the quality and safety of provided care. The purpose of the present study was to investigate the moderating effect of job control on the relationship between workload and burnout. Methods: A total of 352 hospital workers from five Italian public hospitals completed a self-administered questionnaire that was used to measure exhaustion, cynicism, job control, and workload. Data were collected in 2013. Results: In contrast to previous studies, the results of this study supported the moderation effect of job control on the relationship between workload and exhaustion. Furthermore, the results found support for the sequential link from exhaustion to cynicism. Conclusion: This study showed the importance for hospital managers to carry out management practices that promote job control and provide employees with job resources, in order to reduce the burnout risk.
Metabolomics Approach in the Study of the Well-Defined Polyherbal Preparation Zyflamend
Eric D. Tague,Allen K. Bourdon,Amber MacDonald,Maggie S. Lookadoo,Edward D. Kim,Wesley M. White,Paul D. Terry,Shawn R. Campagna,Brynn H. Voy,Jay Whelan 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.3
Zyflamend is a highly controlled blend of 10 herbal extracts that synergistically impact multiple cell signaling pathways with anticancer and anti-inflammatory properties. More recently, its effects were shown to also modify cellular energetics, for example, activation of fatty acid oxidation and inhibition of lipogenesis. However, its general metabolic effects in vivo have yet to be explored. The objective of this study was to characterize the tissue specific metabolomes in response to supplementation of Zyflamend in mice, with a comparison of equivalent metabolomics data generated in plasma from humans supplemented with Zyflamend. Because Zyflamend has been shown to activate AMPK, the “energy sensor” of the cell, in vitro, the effects of Zyflamend on adiposity were also tested in the murine model. C57BL/6 mice were fed diets that mimicked the macro- and micronutrient composition of the U.S. diet with and without Zyflamend supplementation at human equivalent doses. Untargeted metabolomics was performed in liver, skeletal muscle, adipose, and plasma from mice consuming Zyflamend and in plasma from humans supplemented with Zyflamend at an equivalent dose. Adiposity in mice was significantly reduced in the Zyflamend-treated animals (compared with controls) without affecting body weight or weight gain. Based on KEGG pathway enrichment, purine and pyrimidine metabolism (potential regulators of AMPK) were particularly responsive to Zyflamend across all tissues, but only in mice. Consistent with the metabolomics data, Zyflamend activated AMPK and inhibited acetyl CoA-carboxylase in adipose tissue, key regulators of lipogenesis. Zyflamend reduces adipose tissue in mice through a mechanism that likely involves the activation of AMPK.