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Mass transfer coefficient of slug flow for organic solvent-aqueous system in a microreactor
Ana Jurinjak Tušek,Iva Anić,Želimir Kurtanjek,Bruno Zelić 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.6
Application of microreactor systems could be the next break-through in the intensification of chemical and biochemical processes. The common flow regime for organic solvent-aqueous phase two-phase systems is a segmented flow. Internal circulations in segments cause high mass transfer and conversion. We analyzed slug flow in seven systems of organic solvents and aqueous phase. To analyze how slug lengths in tested systems depend on linear velocity and physical and chemical properties of used organic solvents, regression models were proposed. It was shown that models based on linearization of approximation by potentials give low correlation for slug length prediction; however, application of an essential nonlinear model of multiple layer perceptron (MLP) neural network gives high correlation with R2=0.9. General sensitivity analysis was applied for the MLP neural network model, which showed that 80% of variance in slug length for the both phases is accounted for the viscosity and density of the organic phases; 10% is accounted by surface tension of the organic phase, while molecular masses and flow rates each account for 5%. For defined geometry of microreactor, mass transfer has been determined by carrying out the neutralization experiment with NaOH where acetic acid diffuses from organic phase (hexane) into aqueous phase. Estimated mass transfer coefficients were in the range kLa=4,652-1,9807 h−1.
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Biotransformation in a Microreactor: New Method for Production of Hexanal
Anita Šalic,Ana Tušek,Želimir Kurtanjek,Bruno Zeli 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.3
In this study, enzymatic oxidation of hexanol to hexanal (green note fragrance) using NAD^+ dependent commercial alcohol dehydrogenase from S. cerevisiae was conducted in continuously operated tubular microreactors with internal volumes of 6 and 13 μL and in a tubular microreactor with a volume of 2 μL that was equipped with internal micromixers. Flow profiles in microchannel were observed in experiments in which the aqueous phase was stained brilliant blue and the hexane was kept colourless. The effects of enzyme and coenzyme inlet concentrations and flow ratios of the immiscible phases on the conversion of hexanol and the volumetric productivity of hexanal were analyzed. Significant improvement in the conversion of hexanol when compared to the classical macroscale process was obtained for c^(i,hexanol) = 5.5 mmol/L,c^(i,NAD+) = 0.55 mmol/L, and γ^(i,ADH) = 0.092 g/L. In the 6 μL microreactor 11.78% conversion of hexanol was attained after 72 sec, while in the macroscale process 5.3%conversion of hexanol was reached after 180 sec.
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