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RISS 인기검색어
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- 저자 : Brezovich, Ivan A. (검색결과 1 건)
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Dose optimization of breast balloon brachytherapy using a stepping Ir192 HDR source
Choi, Chang Hyun,Ye, Sung‐,Joon,Parsai, E. Ishmael,Shen, Sui,Meredith, Ruby,Brezovich, Ivan A.,Ove, Roger John Wiley and Sons Inc. 2009 Journal of applied clinical medical physics Vol.10 No.1
<P>To develop dose optimization schemes of breast balloon brachytherapy using a stepping of Ir192 HDR source.</P><P>There is a considerable underdosage (11%–13%) of PTV due to anisotropy of a stationary source in breast balloon brachytherapy. We improved the PTV coverage by varying multiple dwell positions and weights. We assumed that the diameter of spherical balloons varied from 4.0 cm to 5.0 cm, that the PTV was a 1‐cm thick spherical shell over the balloon (reduced by the small portion occupied by the catheter path), and that the number of dwell positions varied from 2 to 13 with 0.25‐cm steps, oriented symmetrically with respect to the balloon center. By assuming that the perfect PTV coverage can be achieved by spherical dose distributions from an isotropic source, we developed an optimization program to minimize two objective functions defined as: (1) the number of PTV‐voxels having more than 10% difference between optimized doses and spherical doses, and (2) the difference between optimized doses and spherical doses per PTV‐voxel.</P><P>The optimal PTV coverage occurred when applying 8–11 dwell positions with weights determined by the optimization scheme. Since the optimization yields ellipsoidal isodose distributions along the catheter, there is relative skin sparing for cases with source movement approximately tangent to the skin. We also verified the optimization in CT‐based treatment planning systems.</P><P>Our volumetric dose optimization for PTV coverage showed close agreement to linear or multiple‐points optimization results from the literature. The optimization scheme provides a simple and practical solution applicable to the clinic.</P><P>PACS number: 87.55.de</P>
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