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( Martin Riegl ),( Bohumil Dobos ),( Jan Becka ) 한국EU학회 2018 Asia-Pacific Journal of EU Studies Vol.16 No.1
The paper presents the geoeconomics and geopolitics of the two major trade proposals ― Transatlantic Trade and Investment Partnership and One Belt One Road ― from the Central European perspective. First, the Visegrad Group is presented as a loose, nevertheless significant, grouping of the four post-communist countries in Central Europe. Furthermore, it argues that both TTIP and OBOR are manifestations of the geopolitical strategies of respectively the US and the PRC. After examining the European trade strategy, the paper argues that the Visegrad 4 approach towards these proposals reflects the internal political strife rather than a coherent shift in the foreign policy orientation away from the pro- Western orientation. For the V4 countries, the economic and security ties to Western Europe and the US remain crucial, despite the growing pro-Eastern tendencies in a part of the population and political representation.
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Standardization of RNA Chemical Mapping Experiments
Kladwang, Wipapat,Mann, Thomas H.,Becka, Alex,Tian, Siqi,Kim, Hanjoo,Yoon, Sungroh,Das, Rhiju American Chemical Society 2014 Biochemistry Vol.53 No.19
<P/><P>Chemical mapping experiments offer powerful information about RNA structure but currently involve ad hoc assumptions in data processing. We show that simple dilutions, referencing standards (GAGUA hairpins), and HiTRACE/MAPseeker analysis allow rigorous overmodification correction, background subtraction, and normalization for electrophoretic data and a ligation bias correction needed for accurate deep sequencing data. Comparisons across six noncoding RNAs stringently test the proposed standardization of dimethyl sulfate (DMS), 2′-OH acylation (SHAPE), and carbodiimide measurements. Identification of new signatures for extrahelical bulges and DMS “hot spot” pockets (including tRNA A58, methylated <I>in vivo</I>) illustrates the utility and necessity of standardization for quantitative RNA mapping.</P>
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