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Bioactive Constituents of Marine Sponges of the Genus Spongosorites
Bao, Baoquan,Hong, Jongki,Lee, Chong-O.,Cho, Hee Young,Jung, Jee H. The Korean Society for Marine Biotechnology 2006 한국해양바이오학회지 Vol.1 No.3
This report reviews the literatures on chemical constituents of marine sponges of the genus Spongosorites and also highlights our own research. Specific biological activities of the metabolites from these sponges include: cytotoxic, antitumor, antibacterial, antifungal, antiviral, anti-inflammatory, and other pharmacological activities.
New Cerebrosides from a Marine Sponge <i>Haliclona</i> (<i>Reniera</i>) sp.
Park, Taeseong,Mansoor, Tayyab Ahmad,Shinde, Pramod Bapurao,Bao, Baoquan,Hong, Jongki,Jung, Jee Hyung The Pharmaceutical Society of Japan 2009 Chemical & pharmaceutical bulletin Vol.57 No.1
<P>A chemical investigation of the MeOH extract of a marine sponge <I>Haliclona</I> (<I>Reniera</I>) sp., collected off the coast of Ulleung Island, Korea, led to the isolation of thirteen new cerebrosides (1—3, 5—14), along with a known analogue (4). Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy, MS spectrometry, and chemical method. The major new features of these glucocerebrosides are C<SUB>15</SUB> and C<SUB>19</SUB> acyl chains, long (C<SUB>24</SUB>–C<SUB>28</SUB>) acyl chains, or the <I>S</I>-configuration of the acyl chains. It is noteworthy that both <I>R</I>- and <I>S</I>-configurations of the acyl chains were observed in the same specimen.</P>