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        Nano-alumina coated with SDS and modified with salicylaldehyde-5-sulfonate for extraction of heavy metals and their determination by anodic stripping voltammetry

        Maryam Rajabi,Bahram Mohammadi,Alireza Asghari,Behruz Barfi,Mahdi Behzad 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5

        A green and highly selective solid phase extraction was employed for simultaneous preconcentration and determination of lead and zinc ions in complex real samples by differential pulse anodic stripping voltammetry. The presented method is based on the adsorption of zinc and lead ions on SDS-coated nano-alumina modified with sodium salicylaldehyde-5-sulfonate (SAS). The influence of effective parameters on the separation and preconcentration of the analytes, such as amount of adsorbent, pH and flow rate of sample, volume and concentration of eluent, and effect of possible matrix ions was investigated. Under the best conditions (eluent: HNO3, 3.0 mL, 3.0 mol L-1; adsorbent: 0.7 g of nanoalumina, 30 mg of SDS, 9.4 mg of SAS; and sample: pH 5), adsorption capacity, enrichment factors, and limits of detection for metal ions were 7.8–8.5 mg g-1, 83–167 and 0.0046–0.026 mg L-1, respectively. Calibration graphs were linear in the range of 0.01–100 and 0.08–150 mg L-1 for Pb (II) and Zn (II), respectively. At the end, the proposed method was successfully applied for determination of the analytes in tap water and different food samples such as rice seed, apple juice, coriander and lettuce.

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        Nano-alumina coated with sodium dodecyl sulfate and modified with 4-(2-Pyridylazo) resorcinol for extraction of heavy metals in different matrixes

        Alireza Asghari,Bahram Mohammadi 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.3

        A green, novel and efficient solid phase extraction method based on the use of nano-alumina (nano-Al2O3) coated with sodium dodecyl sulfate (SDS) and modified with 4-(2-Pyridylazo) resorcinol (PAR) asa new adsorbent was developed for separation and preconcentration of trace amounts of Ni, Pb, Cu andZn ions prior to determination by inductively coupled plasma-optical emission spectrometry (ICP-OES). Under the optimum conditions (eluent: HNO3, 4.0 mL, 3.0 mol L-1; adsorbent: 0.8 g of nano-Al2O3,40 mg of SDS, 8.6 mg of PAR; and sample: pH 6, flow rate 2.0 mL min-1), adsorption capacity of nano-Al2O3-SDS-PAR, enrichment factors and limits of detection for the analytes were 8.7–12.9 mg g-1, 125–250, and 0.12–0.71 mg L-1, respectively. The proposed method presented excellent repeatability withrelative standard deviations less than 1.6% (n = 10), and calculated calibration curves gave good level oflinearity with correlation coefficient values between 0.989 and 0.999. Finally, the feasibility of themethod was evaluated by extraction and determination of Ni, Pb, Cu and Zn ions in rice seed, apple juice,coriander, lettuce and tap water samples.

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        Association of immunohistochemical markers of tumor subtype with response to neoadjuvant chemotherapy and survival in patients with muscle-invasive bladder cancer

        Abolfazl Razzaghdoust,Mahdi Ghajari,Abbas Basiri,Peyman Mohammadi Torbati,Anya Jafari,Mohammad-Reza Fattahi,Maryam Salahi,Bahram Mofid 대한비뇨의학회 2021 Investigative and Clinical Urology Vol.62 No.3

        Purpose: A readily accessible biomarker to identify which patients with bladder cancer are more likely to respond to neoadjuvant chemotherapy (NAC) could help clinicians avoid unnecessary chemotherapy and prevent its subsequent complications in some patients. The primary objective of this study was to investigate the association of immunohistochemical markers of tumor subtype with response to NAC and survival of patients with muscle-invasive bladder cancer (MIBC). Materials and Methods: MIBC patients treated with NAC were retrospectively included. The tissue microarrays were assembled from transurethral resection of bladder tumor (TURBT) specimens and immunohistochemistry (IHC) was performed. The association of independent variables, including IHC markers, and clinical covariates with clinical complete response to NAC and with overall survival was assessed by using logistic regression and Cox proportional hazard regression analysis, respectively. Kaplan-Meier curves were plotted for different IHC-based tumor subtypes. Results: Data from 140 MIBC patients treated with NAC were retrospectively reviewed. A total of 63 patients with available TURBT specimens were eligible to be included in the analysis. Our results showed that the IHC signature of KRT5/6(+)/KRT20(−), as a combined marker of basal subtype, was the only covariate significantly associated with complete response to NAC (p=0.037). Moreover, we found no statistically significant differences in overall survival between different IHC-based subtypes (p=0.721). Conclusions: The IHC expression of KRT5/6 and KRT20, as a readily accessible combined marker, may help us to identify the patients most likely to benefit from chemotherapy. The clinical utility of this marker needs to be established in larger prospective studies.

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