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RISS 인기검색어
- 검색키워드
- 저자 : Angelene Prasanna (검색결과 2 건)
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Pre clinical studies of $Streblus$ $asper$ Lour in terms of behavioural safety and toxicity
Kumar, R.B. Suresh,Puratchikodi, A.,Prasanna, Angelene,Dolai, Narayan,Majumder, Piyali,Mazumder, U.K.,Haldar, P.K. 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4
$Streblus$ $asper$ Lour (Family: Moraceae) is a medicinal plant wildly grows in most part of Asian countries. It has many traditional uses like leprosy, piles, diarrhoea, dysentery, elephantiasis, cancer etc. This present study was relates in terms of behavioural safety and toxicity studies of methanol and petroleum ether extracts of $S.$ $asper$. Brine Shrimps lethality bioassay method was established for the present study and cytotoxicity was reported in terms of 50% lethality concentration ($LC_{50}$). Different concentrations of drug solutions were added to the Brine Shrimps, surviving shrimps were counted after 24 h and 50% lethality concentration ($LC_{50}$) were assessed. Acute toxicity was studied on Swiss albino mice after single dose. Sub-Chronic toxicity was performed for 28 days and assessed with biochemical and histopathological parameters. On cytotoxicity studies of brine shrimps it was found methanol extract of $S.$ $asper$ (MESA) was weakly toxic, may be due to the presence of cardiac glycosides and bioactive compounds, however petroleum ether extract of $S.$ $asper$ (PESA) was non toxic. But, in case of acute and sub-acute toxicity study both extracts were found to be non-toxic.
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Pre clinical studies of Streblus asper Lour in terms of behavioural safety and toxicity
R. B. Suresh Kumar,A. Puratchikodi,Angelene Prasanna,Narayan Dolai,Piyali Majumder,U. K. Mazumder,P. K. Haldar 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4
Streblus asper Lour (Family: Moraceae) is a medicinal plant wildly grows in most part of Asian countries. It has many traditional uses like leprosy, piles,diarrhoea, dysentery, elephantiasis, cancer etc. This present study was relates in terms of behavioural safety and toxicity studies of methanol and petroleum ether extracts of S. asper. Brine Shrimps lethality bioassay method was established for the present study and cytotoxicity was reported in terms of 50% lethality concentration (LC_(50)). Different concentrations of drug solutions were added to the Brine Shrimps, surviving shrimps were counted after 24 h and 50% lethality concentration (LC_(50)) were assessed. Acute toxicity was studied on Swiss albino mice after single dose. Sub-Chronic toxicity was performed for 28 days and assessed with biochemical and histopathological parameters. On cytotoxicity studies of brine shrimps it was found methanol extract of S. asper (MESA) was weakly toxic, may be due to the presence of cardiac glycosides and bioactive compounds, however petroleum ether extract of S. asper (PESA) was non toxic. But, in case of acute and sub-acute toxicity study both extracts were found to be non-toxic.
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