The Role of Curcuma longa Against Doxorubicin (Adriamycin)-Induced Toxicity in Rats

Al-Tahtawy, Ragaa Hosny Mohamad,El-Bastawesy, Amal Mohamad,Zekry, Zekry Khalid,Al-Mehdar, Hussain A.,Al-said, Mohamad Gamil Abdel Monaam,Aly, Soaad Shaker,Sharawy, Sabry Mohamed,El-Merzabani, Mahmuod The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.2

The major component, called curcumin, of turmeric (Curcuma longa L.) (Family Zingiberaceae) powder is responsible for its biological actions. The present study aimed to prove the protective effect of turmeric extract against doxorubicin (DOX)-induced cardiac, hepatic, and renal toxicity as evaluated in rats. Body weight and urine volume of the animal groups under investigation were recorded daily throughout the experimental period. Also, the cardiac, hepatic, and renal toxicities were determined by estimating the changes in serum activities of the enzymes lactate dehydrogenase (LDH) and creatine kinase (CK), serum levels of alanine aminotransferase, aspartate aminotransferase, nitric oxide, albumin, and calcium, and kidney and liver tissue activities of superoxide dismutase and glutathione peroxidase, as well as the contents of glutathione and malondialdehyde. Hyperlipidemia was also determined, and protein and albumin changes in urine were estimated. Biochemical and histopathological findings demonstrate that turmeric extract has multiple therapeutic activities that are beneficially protective, and it has an ameliorative effect against DOX-induced cardiac toxicity and hepatotoxicity and blocks DOX-induced nephrosis. Similarly, turmeric extract inhibited the DOX-induced increase in plasma cholesterol, LDH, and CK. The present findings conclude that the turmeric extract has multiple therapeutic activities that block the cardiac, hepatic, and renal toxicities induced by DOX, and it also possibly acts as a free radical scavenger.

Camel Milk as an Adjuvant Therapy for the Treatment of Type 1 Diabetes: Verification of a Traditional Ethnomedical Practice

Al-Tahtawy, Ragaa Hosny Mohamad,Zekry, Zekry Khalid,Al-Mehdar, Hussain A.,Salama, Omar,El-Shaieb, Siad Ebrahim,El-Basmy, Amany A.,Al-said, Mohamad Gamil Abdel Monem,Sharawy, Sabry Mohamed The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.2

There is a traditional belief in the Middle East that regular consumption of camel milk may aid in prevention and control of diabetes. The aim of this work was to evaluate the efficacy of camel milk as an adjuvant therapy in young type 1 diabetics. This 16-week randomized study enrolled 54 type 1 diabetic patients (average age 20 years) selected from those attending the outpatient diabetes clinic of the Menofia University Hospital, affiliated with Egypt's National Cancer Institute. Subjects were randomly divided into two groups of 27 patients: one received usual management (diet, exercise, and insulin), whereas the other received 500 mL of camel milk daily in addition to standard management. A control group of 10 healthy subjects was also assessed. The following parameters were evaluated at baseline and at 4 and 16 weeks: hemoglobin A1c (HbA1c), human C-peptide, lipid profile, serum insulin, anti-insulin antibodies, creatinine clearance, albumin in 24-hour urine, body mass index, and Diabetes Quality of Life score. The following parameters were significantly different between the usual-management group versus the camel milk group after 16 weeks: fasting blood sugar ($227.2\;{\pm}\;17.7$ vs. $98.9\;{\pm}\;16.2\;mg/dL$), HbA1c ($9.59\;{\pm}\;2.05$[%] vs. $7.16\;{\pm}\;1.84$[%]), serum anti-insulin antibodies ($26.20\;{\pm}\;7.69$ vs. $20.92\;{\pm}\;5.45\;{\mu}U/mL$), urinary albumin excretion ($25.17\;{\pm}\;5.43$ vs. $14.54\;{\pm}\;5.62\;mg/dL$/24 hours), daily insulin dose ($48.1\;{\pm}\;6.95$ vs. $23\;{\pm}\;4.05$ units), and body mass index ($18.43\;{\pm}\;3.59$ vs. $24.3\;{\pm}\;2.95\;kg/m^2$). Most notably, C-peptide levels were markedly higher in the camel milk group ($0.28\;{\pm}\;0.6$ vs. $2.30\;{\pm}\;0.51\;pmol/mL$). These results suggest that, as an adjunct to standard management, daily ingestion of camel milk can aid metabolic control in young type 1 diabetics, at least in part by boosting endogenous insulin secretion.

The Role of Curcuma longa Against Doxorubicin (Adriamycin)-Induced Toxicity in Rats

Ragaa Hosny Mohamad,Amal Mohamad El-Bastawesy,Zekry Khalid Zekry,Hussain A. Al-Mehdar,Mohamad Gamil Abdel Monaam Al-said,Soaad Shaker Aly,Sabry Mohamed Sharawy,Mahmuod M. El-Merzabani 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.2

The major component, called curcumin, of turmeric (Curcuma longa L.) (Family Zingiberaceae) powder is responsible for its biological actions. The present study aimed to prove the protective effect of turmeric extract against doxorubicin (DOX)-induced cardiac, hepatic, and renal toxicity as evaluated in rats. Body weight and urine volume of the animal groups under investigation were recorded daily throughout the experimental period. Also, the cardiac, hepatic, and renal toxicities were determined by estimating the changes in serum activities of the enzymes lactate dehydrogenase (LDH) and creatine kinase (CK), serum levels of alanine aminotransferase, aspartate aminotransferase, nitric oxide, albumin, and calcium, and kidney and liver tissue activities of superoxide dismutase and glutathione peroxidase, as well as the contents of glutathione and malondialdehyde. Hyperlipidemia was also determined, and protein and albumin changes in urine were estimated. Biochemical and histopathological findings demonstrate that turmeric extract has multiple therapeutic activities that are beneficially protective, and it has an ameliorative effect against DOX-induced cardiac toxicity and hepatotoxicity and blocks DOX-induced nephrosis. Similarly, turmeric extract inhibited the DOX-induced increase in plasma cholesterol, LDH, and CK. The present findings conclude that the turmeric extract has multiple therapeutic activities that block the cardiac, hepatic, and renal toxicities induced by DOX, and it also possibly acts as a free radical scavenger.

Camel Milk as an Adjuvant Therapy for the Treatment of Type 1 Diabetes: Verification of a Traditional Ethnomedical Practice

Ragaa Hosny Mohamad,Zekry Khalid Zekry,Hussain A. Al-Mehdar,Omar Salama,Siad Ebrahim El-Shaieb,Amany A. El-Basmy,Mohamad Gamil Abdel Monem Al-said,Sabry Mohamed Sharawy 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.2

There is a traditional belief in the Middle East that regular consumption of camel milk may aid in prevention and control of diabetes. The aim of this work was to evaluate the efficacy of camel milk as an adjuvant therapy in young type 1 diabetics. This 16-week randomized study enrolled 54 type 1 diabetic patients (average age 20 years) selected from those attending the outpatient diabetes clinic of the Menofia University Hospital, affiliated with Egypt's National Cancer Institute. Subjects were randomly divided into two groups of 27 patients: one received usual management (diet, exercise, and insulin), whereas the other received 500 mL of camel milk daily in addition to standard management. A control group of 10 healthy subjects was also assessed. The following parameters were evaluated at baseline and at 4 and 16 weeks: hemoglobin A1c (HbA1c), human C-peptide, lipid profile, serum insulin, anti-insulin antibodies, creatinine clearance, albumin in 24-hour urine, body mass index, and Diabetes Quality of Life score. The following parameters were significantly different between the usual-management group versus the camel milk group after 16 weeks: fasting blood sugar (227.2 ± 17.7 vs. 98.9 ± 16.2 mg/dL), HbA1c (9.59 ± 2.05[%] vs. 7.16 ± 1.84[%]), serum anti-insulin antibodies (26.20 ± 7.69 vs. 20.92 ± 5.45 μU/mL), urinary albumin excretion (25.17 ± 5.43 vs. 14.54 ± 5.62 mg/dL/24 hours), daily insulin dose (48.1 ± 6.95 vs. 23 ± 4.05 units), and body mass index (18.43 ± 3.59 vs. 24.3 ± 2.95 kg/m2). Most notably, C-peptide levels were markedly higher in the camel milk group (0.28 ± 0.6 vs. 2.30 ± 0.51 pmol/mL). These results suggest that, as an adjunct to standard management, daily ingestion of camel milk can aid metabolic control in young type 1 diabetics, at least in part by boosting endogenous insulin secretion.

Developing A Service Oriented E-Government Architecture Towards Achieving E-Government Interoperability

Zuhoor Al-Khanjari,Nasser Al-Hosni,Naoufel Kraiem 보안공학연구지원센터 2014 International Journal of Software Engineering and Vol.8 No.5

Endophytes <i>Aspergillus caespitosus</i> LK12 and <i>Phoma</i> sp. LK13 of <i>Moringa peregrina</i> produce gibberellins and improve rice plant growth

Khan, Abdul Latif,Waqas, Muhammad,Hussain, Javid,Al-Harrasi, Ahmed,Al-Rawahi, Ahmed,Al-Hosni, Khadija,Kim, Min-Ji,Adnan, Muhammad,Lee, In-Jung Informa UK (TaylorFrancis) 2014 Journal of plant interactions Vol.9 No.1

Antioxidant and Anticarcinogenic Effects of Methanolic Extract and Volatile Oil of Fennel Seeds (Foeniculum vulgare)

Ragaa Hosny Mohamad,Amal Mohamad El-Bastawesy,Mohamad Gamil Abdel-Monem,Assmaa Mahmoud Noor,Hussain Abdel Rahman Al-Mehdar,Sabry Mohamad Sharawy,Mahmuod Mohamad El-Merzabani 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9

The present study evaluated the efficacy of fennel seed methanolic extract (FSME) for its antioxidant, cytotoxic, and antitumor activities and for its capacity to serve as a nontoxic radioprotector in Swiss albino mice. We also assessed the natural antioxidant compounds of FSME for use in industrial application. Cytotoxic activity of FSME was evaluated in a mouse model of Ehrlich ascites carcinoma (EAC) and on different types of human cell lines in vitro. The safety and optimum dose of FSME were determined. FSME, 100 mg/kg, was injected intraperitoneally into mice bearing EAC before the mice were exposed to three 2-Gy doses of gamma irradiation. After 30 days, mice were fasted for 18 hours and then sacrificed to observe the lifespan of EAC-bearing hosts. Malondialdehyde (MDA), catalase activity, glutathione content, and total protein in serum, liver tissue, and ascitic fluid were determined. Iron, total iron-binding capacity, transferrin, and ferritin were also evaluated in serum. The data showed the presence of different types of compounds in FSME, such as flavonoids, terpenoids, alkaloids, phenols, and sterols; estragole (71.099%) was the predominant alcohol, gallic acid was the phenolic compound (18.895%), and L-limonene was the most prevalent monoterpene hydrocarbon (11.967%). The mean±standard deviation 50% inhibitory concentrations were 50±0.03 μg/mL for the MCF7 breast cancer cell line and 48±022 μg/mL for the Hepg-2 liver cancer cell line. The significant increase in MDA levels and the significant decrease in catalase activity and glutathione content in liver and tumor tissue in mice bearing EAC were ameliorated after FSME administration. In contrast, total protein content was increased in ascitic fluid. Serum iron was inversely proportional to the levels of ferritin and transferrin and total iron-binding capacity. Administration of FSME before irradiation exerted a cytoprotective effect against gamma irradiation, as manifested by a restoration of the MDA level, catalase activity, and GSH content to near-normal levels. In conclusion, FSME may have remarkable anticancer potential against a breast cancer cell line (MCF7) and liver cancer cell line (Hepg-2). It also showed strong free radical–scavenging activity (100%). Thus, FSME may reduce oxidative stress and protect mouse cells from damage caused by reactive oxygen species. In addition, it could be used as a safe, effective, and easily accessible source of natural antioxidants to improve the oxidative stability of fatty foods during storage. FSME also exhibited an antitumor effect by modulating lipid peroxidation and augmenting the antioxidant defense system in EAC-bearing mice with or without exposure to radiation.

FTIR study of gamma and electron irradiated high-density polyethylene for high dose measurements

Hanan Al-Ghamdi,Khaled Farah,Aljawharah Almuqrin,Faouzi Hosni 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.1

A reliable and well-characterized dosimetry system which is traceable to the international measurementsystem, is the key element to quality assurance in radiation processing with cobalt-60 gamma rays, Xrays,and electron beam. This is specifically the case for health-regulated processes, such as the radiationsterilization of single use medical devices and food irradiation for preservation and disinfestation. Polyethylene is considered to possess a lot of interesting dosimetric characteristics. In this work, adetailed study has been performed to determine the dosimetric characteristics of a commercialized highdensitypolyethylene (HDPE) film using Fourier transformed infrared spectrometry (FTIR). Correlationshave been established between the absorbed dose and radiation induced infrared absorption in polyethylenehaving a maximum at 965 cm 1 (transvinylene band) and 1716 cm 1 (ketone-carbonyl band). We have found that polyethylene dose-response is linear with dose for both bands up to1000 kGy. Fortransvinylene band, the dose-response is more sensitive if irradiations are made in helium. While, forketone-carbonyl band, the dose-response is more sensitive when irradiations are carried out in air. Thedose-rate effect has been found to be negligible when polyethylene samples are irradiated with electronbeam high dose rates. The irradiated polyethylene is relatively stable for several weeks after irradiation.

Enhancing value of quality assurance rounds in improving radiotherapy management: a retrospective analysis from King Hussein Cancer Center in Jordan

Khader, Jamal K.,Al-Mousa, Abdelatif M.,Mohamad, Issa A.,Abuhijlih, Ramiz A.,Al-Khatib, Sondos A.,Alnsour, Anoud Z.,Asha, Wafa A.,Ramahi, Shada W.,Hosni, Ali A.,Abuhijla, Fawzi J. The Korean Society for Radiation Oncology 2019 Radiation Oncology Journal Vol.37 No.1

Purpose: The quality assurance (QA) chart rounds are multidisciplinary meetings to review radiation therapy (RT) treatment plans. This study focus on describing the changes in RT management based on QA round reviews in a single institution. Materials and Methods: After 9 full years of implementation, a retrospective review of all patients whose charts passed through departmental QA chart rounds from 2007 to 2015. The reviewed cases were presented for RT plan review; subcategorized based on decision in QA rounds into: approved, minor modifications or major modifications. Major modification defined as any substantial change which required patient re-simulation or re-planning prior to commencement of RT. Minor modification included treatment plan changes which didn't necessarily require RT re-planning. Results: Overall 7,149 RT treatment plans for different anatomical sites were reviewed at QA rounds. From these treatment plans, 6,654 (93%) were approved, 144 (2%) required minor modifications, while 351 (5%) required major modifications. Major modification included changes in: selected RT dose (96/351, 27%), target volume definition (127/351, 36%), organs-at-risk contouring (10/351, 3%), dose volume objectives/constraints criteria (90/351, 26%), and intent of treatment (28/351, 8%). The RT plans which required major modification according to the tumor subtype were as follows: head and neck (104/904, 12%), thoracic (12/199, 6%), gastrointestinal (33/687,5%), skin (5/106, 5%), genitourinary (16/359, 4%), breast (104/2387, 4%), central nervous system (36/846, 4%), sarcoma (11/277, 4%), pediatric (7/251, 3%), lymphoma (10/423, 2%), gynecological tumors (2/359, 1%), and others (11/351, 3%). Conclusion: Multi-disciplinary standardized QA chart rounds provide a comprehensive and an influential method on RT plans and/or treatment decisions.

Enhancing value of quality assurance rounds in improving radiotherapy management: a retrospective analysis from King Hussein Cancer Center in Jordan

Fawzi J. Abuhijla, MD, MSc,Abdelatif M. Al-Mousa,Issa A. Mohamad,Ramiz A. Abuhijlih,Sondos A. Al-Khatib,Anoud Z. Alnsour,Wafa A. Asha,Shada W. Ramahi,Ali A. Hosni,Fawzi J. Abuhijla 대한방사선종양학회 2019 Radiation Oncology Journal Vol.37 No.1

Purpose: The quality assurance (QA) chart rounds are multidisciplinary meetings to review radiation therapy (RT) treatment plans. This study focus on describing the changes in RT management based on QA round reviews in a single institution. Materials and Methods: After 9 full years of implementation, a retrospective review of all patients whose charts passed through departmental QA chart rounds from 2007 to 2015. The reviewed cases were presented for RT plan review; subcategorized based on decision in QA rounds into: approved, minor modifications or major modifications. Major modification defined as any substantial change which required patient re-simulation or re-planning prior to commencement of RT. Minor modification included treatment plan changes which didn’t necessarily require RT re-planning. Results: Overall 7,149 RT treatment plans for different anatomical sites were reviewed at QA rounds. From these treatment plans, 6,654 (93%) were approved, 144 (2%) required minor modifications, while 351 (5%) required major modifications. Major modification included changes in: selected RT dose (96/351, 27%), target volume definition (127/351, 36%), organs-at-risk contouring (10/351, 3%), dose volume objectives/constraints criteria (90/351, 26%), and intent of treatment (28/351, 8%). The RT plans which required major modification according to the tumor subtype were as follows: head and neck (104/904, 12%), thoracic (12/199, 6%), gastrointestinal (33/687,5%), skin (5/106, 5%), genitourinary (16/359, 4%), breast (104/2387, 4%), central nervous system (36/846, 4%), sarcoma (11/277, 4%), pediatric (7/251, 3%), lymphoma (10/423, 2%), gynecological tumors (2/359, 1%), and others (11/351, 3%). Conclusion: Multi-disciplinary standardized QA chart rounds provide a comprehensive and an influential method on RT plans and/ or treatment decisions.