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- 저자 : Aisha Aminu (검색결과 3 건)
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Aisha Aminu,Hauwa Onozasi Umar,Wusa Makena,Zakaria Alhaji Isa,Zainab Muhammad Goni,Onyinoyi Bethel Onimisi,Barka Ishaku 환경독성보건학회 2023 환경독성보건학회지 Vol.38 No.4
Lead (Pb) poisoning is an environmental substance that accumulates in the hepato-renal tissue, which is hazardous to health, while Anacardium occidentale L. is a tropical herb used to treat oxidative stress and inflammatory diseases. The aim of this study was to investigate the antagonistic effect of Anacardium occidentale leaf extract on lead acetate exposure-induced hepatorenal toxicity in rats. Thirty-six adult Wistar rats were split into six equal groups (n = 6). Group I served as a control, and groups II and III were administered lead acetate (50 mg/kg) and Anacardium occidentale leaf extract (400 mg/kg), respectively, while rats in groups IV–VI were administered Anacardium occidentale (L) extract (200 mg/kg and 400 mg/kg) and 10 mg/kg of Succimer, respectively, and were then administered lead acetate (50 mg/kg). When compared to the group I, rats administered lead acetate showed an increase in hepatic enzymes, urea, creatinine, MDA, TNF-α, and IL-1β (p < 0.001) levels and decreased levels of SOD, CAT, and GSH, whereas Anacardium occidentale prevented the increase in hepatorenal function parameters, oxidative stress, and inflammatory markers (TNF-α and IL-1β) induced by lead acetate. Rats administered only lead acetate had a marked increase in hepatic Pb concentration, severe hepatic steatosis, and renal glomerulus degeneration. However, treatment with Anacardium occidentale extract and succimer decreases the Pb concentration, oxidative stress, and inflammation, and also reduces histological liver steatosis and glomerular cytoarchitecture deterioration in the kidney. The results of this study revealed that Anacardium occidentale extract protects against lead acetate-induced liver and kidney toxicity by decreasing oxidative stress and inflammation.
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Aminu Ahmed BUBA,Aisha Yahya LAWAL 건국대학교 GLOCAL(글로컬)캠퍼스 지식콘텐츠연구소 2023 International Journal of Knowledge Content Develop Vol.13 No.3
A cross sectional survey method was used to determine the utilization of e-resources and their influence on the reading culture of 119 undergraduate students registered with the JD Amin library of Federal University Dutse. The data collected was analysed using both descriptive (frequency counts and means) and inferential statistics (regression analysis). The research found that databases (mean=4.00) and e-journal (mean=4.00) are available to the undergraduate students. It further found that e-resources are often utilized by the undergraduate student, with social media (mean=4.00), databases (mean=4.00) and e-journal (mean=4.00). the most commonly used e-resources. It was also found that erratic power supply (mean=3.91) and inability to seek, obtain and evaluate information (mean=3.67) are the prominent factors hindering the utilization of e-resources. The regression analysis rejected the null hypotheses of the study where it shows that the level of utilization of e-resources have positive statistical correlation (r=0.772) with the reading culture of undergraduate students. The study proposed a conceptual model for the sustainable reading culture of students by libraries providing of e-resources. The general conclusion of the research is that e-resources are necessary tools and are moderately available and adequately utilized for influencing reading culture. The study recommended that Internet facilities should be made available to undergraduate students to facilitate more utilization of e-resources.
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Eduitem Sunday Otong,Wusa Makena,Abel Yashim Solomon,Sebastine Anthony Bazabang,Aisha Aminu,Rachael Henry 환경독성보건학회 2022 환경독성보건학회지 Vol.37 No.4
Mercury chloride (HgCl₂) is a neurotoxicant that remains a health hazard despite numerous efforts to reduce its levels in the environment. The use of medicinal plants in treating various diseases and other toxic agents has grown popular owing to their effectiveness and affordable rates. Andrographis paniculata (A. paniculata) is a plant with astringent and detoxifying characteristics and is widely used worldwide for its medicinal and antioxidant benefits. This study aimed to investigate the possible protective effects of A. paniculata aqueous extract against HgCl2-induced memory impairment, oxidative stress, and brain damage. Twenty-five adult Wistar rats were randomly divided into five groups: control, HgCl₂ 0.5 mg/kg, HgCl₂+AP 250 mg/kg, HgCl₂+AP 500 mg/kg, or HgCl₂+Ascorbic acid 200 mg/kg. For 28 days, administrations were given through oral gavage once a day. HgCl₂ injection resulted in memory impairment, increased glutamate concentrations in the brain, and the production of oxidative stress. Memory impairment was prevented in A. paniculata-treated groups by balancing the levels of AChE and dopamine activities, which then lowered glutamate concentration, avoided oxidative stress, and improved histopathological alterations in the brain. A. paniculata alleviated HgCl₂-induced memory impairment in Wistar rats by increasing the memory index, regulating neurotransmitter levels, and reducing oxidative stress.
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