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- 저자 : ANIL SHUKLA (검색결과 10 건)
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QUALITY ASSURANCE AND MOBILITY PROSPECTS IN INDIAN HIGHER EDUCATION
ANIL SHUKLA,TRIPTA TRIVEDI 서울대학교 사회발전연구소 2008 Journal of Asian Sociology Vol.37 No.1
Higher Education in India is facing two major challenges: one is quality and the other is access. The Gross Enrolment Ratio in Higher Education is around 9%, while in the 11th Five Year Plan (2007~2012) it is proposed to be 15%. This almost doubles the capacity of enrolment while per capita expenditure on students in Higher Education has fallen to 20~25%. For this situation, India has a three pronged strategy ?. increase in the number of Higher Education institutes; increased intake in existing institutes; and emphasis on Distance Education mode. The surge of students towards Higher Education makes the issue of Quality Assurance very pertinent so as to ensure the delivery of agreed standards. Now India’"s thrust is laid on ‘"quality with relevance’" where excellence should be acquired by few institutions and quality be maintained by all. Thus the apex bodies of Indian Higher Education like University Grants Commission, Knowledge Commission, National Assessment and Accreditation Committee are looking for ‘"quality gaps’" and design strategies to reduce these gaps. Whatever is proposed for maintaining quality in Higher Education in the 11th Five Year Plan and the current efforts being taken are analyzed threadbare in this paper, and the views of academicians, educational administrators, students and other stake-holders are also taken into consideration. The results show that quality assurance process is mostly ‘"output’"- oriented, and effective measures for improvement in the ‘"process’" part are still lagging due to different reasons. Also quality measures are focused on ‘"Within National Boundaries’" and emphasis is laid merely on quality audit and accreditation. This paper critically appraises the pros and cons of quality assurance on the mobility of the students as the number of foreign students in India is dwindling and the interest of Indian students in foreign Institutes of Higher Education is rising. Findings of this study suggest that mere mechanical quality control and quality assurance cannot sustain the interest of the students in Indian Higher Education Institutes and the need is of launching quality enhancement programs in a quality culture environment.
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ANIL SHUKLA 서울대학교 교육연구소 2008 Asia Pacific Education Review Vol.9 No.3
Burnout is a concept which was born in the mid 1970's in the USA and with astonishing rapidity has become a catch-word to convey an almost unlimited variety of social and personal problems afflicting workers. It describes a specific dysfunction among helping professionals, believed to be the result of excessive demands made upon their energy, strength and resources. Although a clearly agreed upon definition does not exist, burnout is characterized by the inability to be sufficiently concerned about and involved with service recipients. A burnt out worker tends to withdraw emotionally from the demands of the job. Burnout is reflected in emotional exhaustion and apathy, physical fatigue, lack of energy, psychosomatic illness, increased alcohol and drug consumption, cynicism, inappropriate anger, depression and lack of personal achievements. Now, it is observed that teachers are also showing symptoms of burnout, which directly or indirectly affect their teaching performance. Motivated by these reasons the investigators decided to investigate the status of burnout among secondary school teachers and assess its extent in Indian teachers.
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Shukla, Sandeep,Bajpai, Anil Kumar,Bajpai, Jaya The Polymer Society of Korea 2003 Macromolecular Research Vol.11 No.4
A hydrophilic macromolecular network containing hydrophobic moieties has been prepared by free radical copolymerization of acrylamide and styrene in the presence of poly(vinyl alcohol) (PVA) and its potential as controlled drug delivery carrier was evaluated with tetracycline as a model antibiotic drug. The amount of drug was assayed spectrophotometrically. The network was characterized by optical microscopy, infra-red spectroscopy and structural parameters such as average molecular weight between cross1inks ($M_c$), cross1ink density (q) and number of elastically effective chains ($V_e$) were evaluated. It was found that with increasing concentration of PVA, ST and MBA in the hydrogel, the release rate initially increases but after definite concentrations of the above components the release rate falls. In the case of AM, release rate constantly decreases with increasing AM concentration in the hydrogel.
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Shukla Saurabh,Tripathi Anil Kumar,Verma Shailendra Prasad,Awasthi Nidhi 대한혈액학회 2020 Blood Research Vol.55 No.4
Background Aplastic anemia (AA), an unusual hematological disease, is characterized by hypoplasia of the bone marrow and failure to form blood cells of all three lineages resulting in pancytopenia. This study aimed to investigate TNF--308 and IFN--874 gene polymorphisms and their respective plasma protein levels in patients with AA and healthy controls. Methods Two hundred and forty individuals were included in this study; the case group comprised 120 AA patients, while 120 healthy individuals served as controls. Genotyping was performed using the PCR-restriction length fragment polymorphism method and TNF--308 and IFN--874 plasma levels were evaluated using an ELISA kit. Results There was a significantly higher prevalence of the IFN--874 genotype in patients with AA than in healthy controls, while the TNF--308 genotype was associated with lower risk of developing AA. Furthermore, the levels of both TNF--308 and IFN--874 were higher in the plasma of AA patients. Conclusion Our findings suggest that the IFN--874 genotype may be a greater risk factor in the causation of AA, whereas the TNF--308 genotype has a protective role in the North Indian population.
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Deependra Kumar Yadav,Anil Kumar Tripathi,Divya Gupta,Saurabh Shukla,Aloukick Kumar Singh,Ashutosh Kumar,Jyotsna Agarwal,K. N. Prasad 대한혈액학회 2017 Blood Research Vol.52 No.4
Background: Immune thrombocytopenia (ITP) is an immune-mediated disease caused by autoanti-bodies against platelets membrane glycoproteins GPIIb/IIIa and GPIb/IX. The etiology of ITP remains unclear. This study evaluated the association of polymorphisms in interleukin (IL)-1B-31, IL-1B-511, and IL-1Ra with ITP. Methods: Genotyping of IL-1B-31, IL-1B-511, and IL-1Ra was performed in 118 ITP patients and 100 controls by polymerase chain reaction restriction fragment length polymorphism and detection of variable number tandem repeats. Results: Genotype differences in IL-1B-31 and IL-1Ra were significantly associated with ITP. Patients showed a higher frequency of the IL-1B-31 variant allele (T) and a 1.52-fold greater risk of susceptibility to ITP (odds ratio [OR]=1.52, 95% confidence interval [CI]=1.04‒2.22, P=0.034). The frequencies of both homozygous and heterozygous variant geno-types of IL-1B-31 were higher (OR=2.33, 95% CI=1.069‒5.09, P=0.033 and OR=2.044, 95% CI=1.068‒39, P=0.034) among patients and were significantly associated with ITP susceptibility. Both homozygous and heterozygous variant genotypes of IL-1Ra were also more frequent (OR=4.48, 95% CI=1.17‒17.05, P=0.0230 and OR=1.80, 95% CI=1.03‒3.14, P=0.0494) among patients and were associated with ITP risk. IL-1B-31 and IL-1Ra also showed significant association with severe ITP. However, IL-1B-511 was not asso-ciated with ITP. Conclusion: IL-1B-31 and IL-1Ra polymorphisms may significantly impact ITP risk, and they could be associated with disease severity, which may contribute to the pathogenesis of ITP.
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Optical dating of late Quaternary carbonate sequences of Saurashtra, western India
Sharma, Komal,Bhatt, Nilesh,Shukla, Anil Dutt,Cheong, Dae-Kyo,Singhvi, Ashok Kumar Cambridge University Press 2017 Quaternary research Vol.87 No.1
<B>Abstract</B><P>Bioclastic carbonate deposits that formed because of a combination of nearshore marine, fluvial, and aeolian processes, occur along the Saurashtra coast and in the adjacent interior regions of western India. Whether these carbonates formed by marine or aeolian processes has been debated for many decades. The presence of these deposits inland poses questions as to whether they are climate controlled or attributable to postdepositional tectonic uplift. In particular, the debate centres on chronologic issues including (1) appropriate sampling strategies and (2) the use of <SUP>230</SUP>Th/<SUP>234</SUP>U and <SUP>14</SUP>C ages on the bulk carbonates. Using traces (<1%) of quartz grains trapped in carbonate matrices, optically stimulated luminescence (OSL) dating of quartz grains, deposited along with the carbonate grains, provides ages for the most recent deposition events. The OSL ages range from >165 to 44 ka for the shell limestones, 75-17 ka for the fluvially reworked sheet deposits, and 80-11 ka for miliolites deposited by aeolian processes. These are younger than the <SUP>230</SUP>Th/<SUP>234</SUP>U and <SUP>14</SUP>C ages and suggest that the inland carbonate deposits were reworked from older carbonate sediments that were transported during more arid phases.</P>
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Deependra Kumar Yadav,Anil Kumar Tripathi,Divya Gupta,Saurabh Shukla,Aloukick Kumar Singh,Ashutosh Kumar,Jyotsna Agarwal,K. N. Prasad 대한혈액학회 2017 Blood Research Vol.51 No.4
Background: Immune thrombocytopenia (ITP) is an immune-mediated disease caused by autoanti-bodies against platelets membrane glycoproteins GPIIb/IIIa and GPIb/IX. The etiology of ITP remains unclear. This study evaluated the association of polymorphisms in interleukin (IL)-1B-31, IL-1B-511, and IL-1Ra with ITP. Methods: Genotyping of IL-1B-31, IL-1B-511, and IL-1Ra was performed in 118 ITP patients and 100 controls by polymerase chain reaction restriction fragment length polymorphism and detection of variable number tandem repeats. Results: Genotype differences in IL-1B-31 and IL-1Ra were significantly associated with ITP. Patients showed a higher frequency of the IL-1B-31 variant allele (T) and a 1.52-fold greater risk of susceptibility to ITP (odds ratio [OR]=1.52, 95% confidence interval [CI]=1.04‒2.22, P=0.034). The frequencies of both homozygous and heterozygous variant geno-types of IL-1B-31 were higher (OR=2.33, 95% CI=1.069‒5.09, P=0.033 and OR=2.044, 95% CI=1.068‒39, P=0.034) among patients and were significantly associated with ITP susceptibility. Both homozygous and heterozygous variant genotypes of IL-1Ra were also more frequent (OR=4.48, 95% CI=1.17‒17.05, P=0.0230 and OR=1.80, 95% CI=1.03‒3.14, P=0.0494) among patients and were associated with ITP risk. IL-1B-31 and IL-1Ra also showed significant association with severe ITP. However, IL-1B-511 was not asso-ciated with ITP. Conclusion: IL-1B-31 and IL-1Ra polymorphisms may significantly impact ITP risk, and they could be associated with disease severity, which may contribute to the pathogenesis of ITP.
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Kim, Tae-Sung,Park, Jung-Eun,Shukla, Anil,Choi, Sunho,Murugan, Ravichandran N.,Lee, Jin H.,Ahn, Mija,Rhee, Kunsoo,Bang, Jeong K.,Kim, Bo Y.,Loncarek, Jadranka,Erikson, Raymond L.,Lee, Kyung S. National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.50
<P>Centrosomes play an important role in various cellular processes, including spindle formation and chromosome segregation. They are composed of two orthogonally arranged centrioles, whose duplication occurs only once per cell cycle. Accurate control of centriole numbers is essential for the maintenance of genomic integrity. Although it is well appreciated that polo-like kinase 4 (Plk4) plays a central role in centriole biogenesis, how it is recruited to centrosomes and whether this step is necessary for centriole biogenesis remain largely elusive. Here we showed that Plk4 localizes to distinct subcentrosomal regions in a temporally and spatially regulated manner, and that Cep192 and Cep152 serve as two distinct scaffolds that recruit Plk4 to centrosomes in a hierarchical order. Interestingly, Cep192 and Cep152 competitively interacted with the cryptic polo box of Plk4 through their homologous N-terminal sequences containing acidic-alpha-helix and N/Q-rich motifs. Consistent with these observations, the expression of either one of these N-terminal fragments was sufficient to delocalize Plk4 from centrosomes. Furthermore, loss of the Cep192- or Cep152-dependent interaction with Plk4 resulted in impaired centriole duplication that led to delayed cell proliferation. Thus, the spatiotemporal regulation of Plk4 localization by two hierarchical scaffolds, Cep192 and Cep152, is critical for centriole biogenesis.</P>
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