MEROMORPHIC CLOSE-TO-STAR FUNCTIONS

AHUJA, O.P.,MOGRA, M.L. Korean Mathematical Society 1983 대한수학회지 Vol.20 No.1

Variability in Management Practices and Surgical Decision Making in Spinal Tuberculosis: An Expert Survey-Based Study

Ahuja Kaustubh,Gupta Tushar,Ifthekar Syed,Mittal Samarth,Yadav Gagandeep,Kandwal Pankaj 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.1

Study Design: Electronic survey–based study.Purpose: The aim of the study was to objectively review the variability in the prevailing treatment protocols and surgical decision making in the management of patients with spinal tuberculosis (TB) among spine surgeons with expertise in spinal TB across the country.Overview of Literature: A lack of good-quality evidence, ambiguities in the national spinal TB guidelines, and the demand for early rehabilitation and a better quality of life in patients with spinal TB has led to the emergence of various gray zones in the management of spinal TB.Methods: Seventeen fellowship-trained spinal TB experts representing different geographical regions of India completed an online survey consisting of questions pertaining to the conservative management of spinal TB (antitubercular therapy) and 30 clinical case vignettes including a wide spectrum of presentations of spinal TB with no or minimal neurological deficit. The variability in the responses for questions and case wise variability with respect to surgical decision making was assessed using the index of qualitative variation (IQV). The average tendency to operate (TTO) was calculated for various groups of respondents.Results: High variability was observed in all questions regarding conservative spinal TB management (IQV > 0.8). Among the 30 case vignettes, 14 were found to have high variability with respect to surgical decision making (IQV > 0.8). With respect to levels of fixation, all but two cases had poor or slight agreement. Younger age and practice in a government or tertiary care teaching hospital were factors associated with a higher TTO.Conclusions: Significant variability was detected in treatment practices for the management of spinal TB among experts. Most of the case vignettes were found to have significant heterogeneity with respect to surgical decision making, which reflects a significant lack of consensus and lacunae in literature.

TRPML1 as lysosomal fusion guard

Ahuja, Malini,Park, Soonhong,Shin, Dong Min,Muallem, Shmuel Informa UK (TaylorFrancis) 2016 Channels Vol.10 No.4

ON THE RADIUS PROBLEM OF CERTAIN ANALYTIC FUNCTIONS

Ahuja, O.P. Korean Mathematical Society 1985 대한수학회보 Vol.22 No.1

Rheology of Hydrate-Forming Emulsions Stabilized by Surfactant and Hydrophobic Silica Nanoparticles

Ahuja, Amit,Iqbal, Anam,Iqbal, Mohsin,Lee, Jae W.,Morris, Jeffrey F. American Chemical Society 2018 Energy & fuels Vol.32 No.5

<P>Observed effects of hydrophobic fumed silica nanoparticles (of average primary particle size 7 nm) on the rheological behavior of hydrate-forming emulsions are presented. Liquid cyclopentane (CP) is the hydrate former. The hydrate slurry is prepared in a Couette geometry at atmospheric pressure from a water-in-oil emulsion with the phases density matched to avoid segregation. Hydrates are formed upon quenching to a low temperature at a fixed shear rate. Dispersed water droplets convert to hydrate particles, leading to an effective viscosity increase by orders of magnitude. The hydrate inhibition by silica nanoparticles at the water-oil interface, forming a Pickering type of emulsion, is characterized using the onset time of steep viscosity rise after seeding with small hydrate particles; this is termed the critical time. Seeding eliminates stochasticity associated with nucleation of the hydrate. The critical time is increased when the interface is covered with silica nanoparticles. For a particle concentration range of 0.05-0.5% (by weight based on total oil mass) at the interface, the hydrate crystallization process is delayed by 5 h in comparison to the particle-free case for a 20 vol % water-in-oil emulsion at <I>T</I> = −2 °C and shear rate of γ̇ = 100 s<SUP>-1</SUP>. The final hydrate slurry viscosity was the same as observed in the slurry with no particles. At particle concentrations greater than 1 wt %, the viscosity increased abruptly and ultimately jammed the rheometer during hydrate formation. A hypothesis is presented to explain this latter behavior and indicates some of the limitations of this method of inhibition by nanoparticles. A discussion of factors which may complicate application of the method in the field is provided.</P> [FIG OMISSION]</BR>

Analyzing the interaction of RseA and RseB, the two negative regulators of the sigmaE envelope stress response, using a combined bioinformatic and experimental strategy.

Ahuja, Nidhi,Korkin, Dmitry,Chaba, Rachna,Cezairliyan, Brent O,Sauer, Robert T,Kim, Kyeong Kyu,Gross, Carol A American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.8

<P>The Escherichia coli envelope stress response is controlled by the alternative sigma factor, sigma(E), and is induced when unfolded outer membrane proteins accumulate in the periplasm. The response is initiated by sequential cleavage of the membrane-spanning antisigma factor, RseA. RseB is an important negative regulator of envelope stress response that exerts its negative effects onsigma(E) activity through its binding to RseA. In this study, we analyze the interaction between RseA and RseB. We found that tight binding of RseB to RseA required intact RseB. Using programs that performed global and local sequence alignment of RseB and RseA, we found regions of high similarity and performed alanine substitution mutagenesis to test the hypothesis that these regions were functionally important. This protocol is based on the hypothesis that functionally dependent regions of two proteins co-evolve and therefore are likely to be sequentially conserved. This procedure allowed us to identify both an N-terminal and C-terminal region in RseB important for binding to RseA. We extensively analyzed the C-terminal region, which aligns with a region of RseA coincident with the major RseB binding determinant in RseA. Both allele-specific suppression analysis and cysteine-mediated disulfide bond formation indicated that this C-terminal region of similarity of RseA and RseB identifies a contact site between the two proteins. We suggest a similar protocol can be successfully applied to pairs of non-homologous but functionally linked proteins to find specific regions of the protein sequences that are important for establishing functional linkage.</P>

UPPER BOUNDS OF SECOND HANKEL DETERMINANT FOR UNIVERSALLY PRESTARLIKE FUNCTIONS

Ahuja, Om,Kasthuri, Murugesan,Murugusundaramoorthy, Gangadharan,Vijaya, Kaliappan Korean Mathematical Society 2018 대한수학회지 Vol.55 No.5

In [12,13] the researchers introduced universally convex, universally starlike and universally prestarlike functions in the slit domain ${\mathbb{C}}{\backslash}[1,{\infty})$. These papers extended the corresponding notions from the unit disc to other discs and half-planes containing the origin. In this paper, we introduce universally prestarlike generalized functions of order ${\alpha}$ with ${\alpha}{\leq}1$ and we obtain upper bounds of the second Hankel determinant ${\mid}a_2a_4-a^2_3{\mid}$ for such functions.

Sustainable menstrual products: The challenges ahead

Ahuja Prerna,Singh Navjit 이화여자대학교 아시아여성학센터 2022 Asian Journal of Women's Studies(AJWS) Vol.28 No.3

Taboos regarding menstruation in society have greatly influenced the lives of women. Women and the environment are also affected by the commercialization of menstrual products by the corporate giants that sell these. This exploratory study was undertaken through in-depth interviews to identify the challenges women face while menstruating. It was broadly seen that women were inclined to use traditional or older menstrual products they were used to. Some reasons for the gaps in the awareness and knowledge regarding what have been called sustainable menstrual products (SMPs) have also been identified to represent the themes of Self-concept, Pre-conceived notions, Accessibility, Routines, and Knowledge. We note here that if such gaps in information are addressed, awareness and knowledge about SMPs would increase and lead towards their adoption. Further, we seek to provide future directions for researchers to study some novel menstrual products that are considered sustainable.

A SPECIAL SUBCLASS OF CLOSE TO CONVEX FUNCTIONS

AHUJA, O.P. Korean Mathematical Society 1983 대한수학회지 Vol.20 No.2

Ethnopharmacological properties of <i>Artemisia asiatica</i>: A comprehensive review

Ahuja, Akash,Yi, Young-Su,Kim, Mi-Yeon,Cho, Jae Youl Elsevier 2018 Journal of Ethnopharmacology Vol.220 No.-

<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P> <I>Artemisia asiatica</I> Nakai (Compositae) has a long history as a traditional remedy. Preparation from various parts of the plant (aerial parts and leaves) are used to treat a wide range of diseases including gastric trouble, liver dysfunction, and skin inflammation.</P> <P><B>Aims of this review</B></P> <P>The aims of this review were: 1) to provide an overview of recent studies and progress on <I>A. asiatica</I>-derived ethnopharmacological compounds and their pharmacological activities; and 2) to summarize existing evidence and provide insight for future studies.</P> <P><B>Materials and methods</B></P> <P>This investigation was carried out by analyzing published books and research papers <I>via</I> scientific databases, namely Science Direct, PubMed ACS Publication, Wiley Online Library, CNKI and information obtained online. The keywords “<I>Artemisia asiatica</I> traditional uses,” “Compounds isolated and studied in <I>Artemisia asiatica,</I>” and “Pharmacological advances in <I>Artemisia asiatica</I>” were used and articles published between 1995 and 2017 were considered. In total, 500 works related to biological activities of <I>A. asiatica</I> were identified, and only materials published in English were included in the review.</P> <P><B>Results</B></P> <P>Comparative analysis of literature searched through sources available confirmed that the ethnopharmacological use of <I>A. asiatica</I> was recorded in Korea, China, and Japan. Phytochemical studies revealed the presence of flavonoids, sesquiterpene lactones, monoterpenes, and steroids in <I>A. asiatica</I>. Of these, flavonoids have been shown to exhibit significant pharmacological effects such as gastroprotective, anti-inflammatory, anti-tumor, and anti-microbial actions.</P> <P><B>Conclusions</B></P> <P>Phytochemical and pharmacological studies of <I>Artemisia asiatica</I> have proven that this plant is one of valuable medicinal sources with neuroprotective, gastroprotective, anti-oxidative, anti-inflammatory, and anti-cancer effects. Although ethanol extract of this plant is now being prescribed as gastroprotective and anti-ulcerative medicine, it is now time to expand its application to other human inflammatory diseases such as pancreatitis and hepatitis and further extensive study on toxicity in human. Therefore, the present review will encourage further studies of <I>A. asiatica</I> in the pursuit of wide range of therapeutic remedy.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>