http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
오늘 본 자료
Control of plasma profiles in DIII-D discharges
Gohil, P,Evans, T E,Ferron, J R,Moyer, R A,Petty, C C,Burrell, K H,Casper, T A,Garofalo, A M,Hyatt, A W,Jayakumar, R J,Kessel, C,Kim, J Y,La Haye, R J,Lohr, J,Luce, T C,Makowski, M A,Mazon, D,Menard, Published jointly by The Institute of Physics and 2006 Plasma physics and controlled fusion Vol.48 No.a5
<P>Active control of plasma profiles is an essential requirement for operating within plasma stability limits, for steady-state operation and for optimization of the plasma performance. In DIII-D, plasma profiles have been actively controlled using various actuators in the following manner: (a) real time closed loop control of the <I>q</I> profile evolution using electron cyclotron heating and neutral beam injection as actuators; (b) active control of the density and pressure profiles in quiescent H-mode and quiescent double barrier plasmas using electron cyclotron current drive (ECCD) and pellet injection; (c) active control of the edge profiles to suppress edge localized modes using resonant magnetic perturbation with toroidal mode number <I>n</I> = 3, (d) real time control of the current density profile to suppress neoclassical tearing modes using localized deposition of co-ECCD.</P>
Genetic associations of LYN with systemic lupus erythematosus
Lu, R,Vidal, G S,Kelly, J A,Delgado-Vega, A M,Howard, X K,Macwana, S R,Dominguez, N,Klein, W,Burrell, C,Harley, I T,Kaufman, K M,Bruner, G R,Moser, K L,Gaffney, P M,Gilkeson, G S,Wakeland, E K,Li, Q-Z Macmillan Publishers Limited 2009 GENES AND IMMUNITY Vol.10 No.5
We targeted LYN, a src-tyosine kinase involved in B-cell activation, in case–control association studies using populations of European-American, African-American and Korean subjects. Our combined European-derived population, consisting of 2463 independent cases and 3131 unrelated controls, shows significant association with rs6983130 in a female-only analysis with 2254 cases and 2228 controls (P=1.1 × 10<SUP>−4</SUP>, odds ratio (OR)=0.81 (95% confidence interval: 0.73–0.90)). This single nucleotide polymorphism (SNP) is located in the 5′ untranslated region within the first intron near the transcription initiation site of LYN. In addition, SNPs upstream of the first exon also show weak and sporadic association in subsets of the total European-American population. Multivariate logistic regression analysis implicates rs6983130 as a protective factor for systemic lupus erythematosus (SLE) susceptibility when anti-dsDNA, anti-chromatin, anti-52 kDa Ro or anti-Sm autoantibody status were used as covariates. Subset analysis of the European-American female cases by American College of Rheumatology classification criteria shows a reduction in the risk of hematological disorder with rs6983130 compared with cases without hematological disorders (P=1.5 × 10<SUP>−3</SUP>, OR=0.75 (95% CI: 0.62−0.89)). None of the 90 SNPs tested show significant association with SLE in the African American or Korean populations. These results support an association of LYN with European-derived individuals with SLE, especially within autoantibody or clinical subsets.Genes and Immunity (2009) 10, 397–403; doi:10.1038/gene.2009.19; published online 16 April 2009