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X-線全身照射와 Reduced Glutathione이 마우스 十二指腸의 蛋白量에 미치는 影響
金相道,李基錫,李圭源,李相華,李漢喆 최신의학사 1972 最新醫學 Vol.15 No.2
In an attempt to clarify the effect of whole body X-irradiation on the protein content of the mouse duodenum, and to observe the possible radioprotective action of reduced glutathione(GSH), a whole body X-irradiation of 1, OOOr was given to albino mouse either singularly or immediately after injecting GSH intraperitoneally to mouse 1mg-per gm of body weight. Protein content was measured by the method described by Lowry et al., using Folin phenol reagent, and the experiment was performed at 1, 6, 12 and 24 hours post-irradiation, and the comparison was made with the control. 1 The results obtained are summarized as follows: 1. The protein content of the normal mouse duodenum was 50.3±2.3mg/gm wet wt. 2. The protein content of the duodenum in the X-irradiated group increased at one hour after the irradi ation, but the recovery to the control value was noted after six post-irradiation hour. 3. Reduced glutathione(GSH) produced a slight increase in the protein content of the mouse duodenum at 12 hours after the injection. 4. When the injection of GSH and X-irradiation were combined, the duodenal protein content showed a tendency of decrease throughout the experiment. However, the recovery to the control value was observed at 12 and 24 experimental hours.
寒冷露出 및 X-線全身照射가 마우스 數種臟器의 蛋白量에 미치는 影響
姜秉祚,李相華,李東一,李漢喆,李基錫 慶北大學校 醫科大學 1972 慶北醫大誌 Vol.13 No.1
In an attempt to observe the possible radioprotective action of the low temperature in mammals, the albino mouse was subjected to cold exposure at -1±0.2℃, whole-body, X-irradiation with 900r, and the X-irradiation following the cold exposure for one hour. The levels of protein of the liver, brain and heart were measured at 1/2, 1 and 3 hours after the cold exposure and/or the X-irradiation, and the results were compared with the control, i.e., non-irradiated and non-cold exposed animal. Protein was measured by the method described by Lowry et al. The results obtained are summarized as follows: 1. The level of protein in the liver, brain and heart of the normal mouse was 101.13±17.57,62.79±6.89 and 87.08±6.68㎎/gm wet wt. respectively. 2. The protein content of the liver in the X-irradiated group showed a tendency of increase comparing with the control, though there was a slight decrease at ½hours post-irradiation. In the groups where the cold exposure alone or the combination of the cold exposure and X-irradiation were applied, there was no significant change from the control. 3. The protein content of the brain immediately after the X-irradiation produced no change from the control, but a slight increase was noted at three hours post-irradiation after a slight decrease at ½hours post-irradiation. In the cold exposure group, there was a general tendency of decrease throughout the experiment. When the cold exposure and X-irradiation were combined, there was a tendency of increase in the protein content comparing from the control. 4. The protein content of the heart in the X-irradiated group showed a tendency of increase throughout the experiment with the exception of decrease at ½hours post-irradiation. In the groups where the cold exposure alone or the combination of the cold exposure and X-irradiation were applied, a tendency of decrease in the protein content was observed from the control.