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변위 측정에 의한 무늬 반사식 형상 측정 시스템의 보정
박병현(Byoung-hyun Park),유연석(Yeon-Serk Yu) 한국정보기술학회 2013 한국정보기술학회논문지 Vol.11 No.1
In this (work) experiments we study the data calibration method of fringe reflection profilometry to measure the shape of specular reflection surface. Fringe reflection FTP calibration data measurements system is consist with CCD camera, monitor, precision moving stage for get the relationship between the phase measurement value and actual height values. The fringe reflection reference surface was moved linearly using the precision stage for the measurement of actual height displacement value and the theoretical simulation data was compared. The calibration data depend on the spatial frequency of the fringe patterns and the geometry of the measurements systems also the angle between the CCD camera and the reference object surface. Using the experimentally measured results we obtained the calibration factor k(u, v) of the each image surface points between the actual height of displacement and the phase measurement values was possible.
제2형 당뇨병 환자에서 심혈관계 자율신경병증의 진단에 있어 Colour Change Plaster (NeuroCheck(R)) 검사의 유용성에 관한 연구
김현정 ( Hyun Jung Kim ),임윤혁 ( Yeun Hyuk Lim ),오효정 ( Hyo Jung Oh ),김병수 ( Byung Soo Kim ),김하영 ( Ha Young Kim ),박병현 ( Byoung Hyun Park ),조정구 ( Chung Gu Cho ) 대한내과학회 2006 대한내과학회지 Vol.71 No.2
목적: 최근 보고에 의하면 말초 자율신경병증(교감신경병증)이 심혈관계 부교감신경병증에 선행하여 발생하는 것으로 보고되고 있어 이를 진단하는 것이 심혈관계 자율신경병증을 조기 진단하는데 도움이 될 것으로 생각되었다. 저자들은 최근 당뇨병성 신경병증을 발한기능을 통해 진단하고자 개발된 color change plaster인 뉴로체크(R)를 이용한 말초 자율신경병증의 존재가 심혈관계 자율신경병증 및 당뇨병성 미세혈관합병증과 어떠한 연관성이 있는지 알아보고자 본 연구를 시작하였다. 방법: 평균 연령 55±14.9세, 평균 당뇨병 이환기간 11.8±8.8년인 제2형 당뇨병 환자 35명(남자 10, 여자 25)을 대상으로 뉴로체크(R)를 사용하여 발한기능을 평가하였다. 발한기능 이상은 색깔이 파란색에서 완전히 분홍색으로 변하는 시간이 10분 이상일 경우로 정의 하였으며 말초 자율신경병증(발한기능 장애)이 있는 군과 정상인 군으로 나누었고, 심혈관계 자율신경병증에 대한 검사는 Ewing 등의 방법을 사용하였다. 결과: 1) 말초 자율신경병증은 23명(65.7%)에서 발견되었다. 발한기능이 정상인 군과 비정상인 군의 색깔변화 시작 시간과 완전히 변하는데 까지 걸리는 시간은 각각 38.3±33.7 sec 대 367.1±470.3 sec (p<0.05), 372.5±198.8 sec 대 1677.4±711.9 sec (p<0.05)이었다. 두 군의 Ewing 점수는 각각 2.4±2.3점 대 4.6±2.2점이었다 (p<0.05). 발한기능 이상 군에서 나이가 더 많았다(59.2±11.7 yrs, vs 47±17.4 yrs, p<0.05). 2) 당뇨병성 미세혈관병증 중 망막병증과 발한기능 이상이 연관성이 있었다(p=0.04). 3) 말초 자율신경병증은 심혈관계 부교감 신경병증과 연관이 있었으며 확정적인 심혈관계 자율신경병증과 연관을 보였으나, 초기 심혈관계 자율신경병증과는 연관성을 보이지 않았다. 4) 확정적 심혈관계 자율신경병증의 진단에 있어서 뉴로체크(R)의 민감도, 특이도, 양성 예측률, 음성 예측률은 각각 86.7%, 62.5%, 68.4%, 83.3%이었다. 결론: 새로운 colour change plaster인 뉴로체크(R)를 이용한 발한기능 검사는 당뇨병성 망막병증과 연관성이 있었고, 확정적(definitive) 당뇨병성 심혈관계 자율신경병증을 진단하는데 도움이 될 것으로 생각되나, 초기 심혈관계 자율신경병증을 진단하기에는 좀 더 평가가 필요할 것으로 생각된다. Background: Recently, the colour change plaster (NeuroCheck(R)) has been introduced, which measures sweat production on the basis of a colour change from blue to pink. This new test was useful to detect of diabetic peripheral neuropathy. The aim of this study was to evaluate the usefulness of the colour change plaster (NeuroCheck(R)) for the diagnosis of cardiac autonomic neuropathy in type 2 diabetic patients. Methods: This study include 35 type 2 diabetic patients (10 male, 25 female) with a mean age of 55±14.9 years and a mean diabetes duration of 11.8±8.8 years. Cardiac autonomic neuropathy was diagnosed by means of Ewing`s method. Peripheral autonomic neuropathy (Sudomotor function abnormality) was assessed by means of time (more than 600 seconds) until complete colour change in the indicator test. Results: Peripheral autonomic neuropathy was diagnosed in 23 patients (65.7%). Time until starting colour change of plaster in normal and abnormal sudomotor patients were 38.3±33.7 sec and 367.1±470.3 sec (p<0.05). Time until completing colour change of plaster in normal and abnormal sudomotor patients were 372.5±198.8 sec and 1677.4±711.9 sec (p<0.05). The autonomic score of two groups were 2.4±2.3, 4.6±2.2 (p<0.05). Sudomotor abnormal group was older than normal (59.2±11.7 yrs, vs 47±17.4 yrs). Presence of retinopathy was related with sudomotor abnormality. Peripheral autonomic neuropathy was related with parasympathetic cardiac autonomic neuropathy. Sudomotor function abnormality was related with definite cardiac autonomic neuropathy, but it was not related with early cardiac autonomic neuropathy. The sensitivity, specificity, positive predictive value and negative predictive value of colour change plaster in the diagnosis of definitive cardiovascular autonomic neuropathy was 86.7%, 62.5%, 68.4% and 83.3%, respectively. Conclusions: The colour change plaster (NeuroCheck(R)) is not useful for the early diagnosis of cardiac autonomic neuropathy in type 2 diabetic neuropathy, but it may be possible for the screening test of definite cardiac autonomic neuropathy.(Korean J Med 71:166-172, 2006)
증례 : 내분비-대사 ; 전교통 동맥류 결찰술 후 발생한 무갈증을 동반한 중추성 요붕증 1예
박종빈 ( Jong Bin Park ),진애령 ( Ae Ryung Jin ),유태양 ( Tae Yang Yu ),노혜정 ( Hye Jung Noh ),이문영 ( Moon Young Lee ),박병현 ( Byoung Hyun Park ),조정구 ( Chung Gu Cho ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5S
뇌 병변 및 신경외과적 수술 후 발생하는 중추성 요붕증은 드물며, 갈증 중추인 삼투수용체에 병변이 동반될 경우 전형적인 요붕증의 증상이 구갈, 다음 증상의 발현이 없어 진단이 부적절해지거나 늦어질 수 있다. 저자들은 전교통 동맥류 결찰술을 시행받은 환자에서 무갈증이 동반된 중추성 요붕증 환자를 경험하여 두 가지 질환이 동시에 발생할 수 있음을 염두에 두고 빠른 진단 및 데스모프레신과 적절한 수분공급 등의 치료에 특별한 주의가 필요함을 강조하고자 문헌고찰과 함께 보고하는 바이다. Central diabetes insipidus and adipsic disorders are often accompanied by abnormalities such as hypothalamic lesion. The development of hypothalamic diabetes insipidus with adipsia after clipping of an anterior communicating artery aneurysm has rarely been reported. Recently, we experienced a 52-year-old woman who presented with adipsia, polyuria, and hypernatremia after clipping of a ruptured aneurysm in the anterior communicating artery. She was diagnosed with hypothalamic diabetes insipidus and adipsic disorder and treated with intranasal desmopressin and regular water intake. This is the 11th case of adipsic diabetes insipidus associated with an anterior communicating artery aneurysm in the world, and the first reported case in Korea. (Korean J Med 77:S1217-S1221, 2009)
제2형 당뇨병 환자에서 아스피린 저항성 빈도와 연관인자에 관한 연구
임윤혁 ( Yun Hyek Lim ),박병현 ( Byoung Hyun Park ),조정구 ( Chung Gu Cho ) 대한내과학회 2009 대한내과학회지 Vol.76 No.3
Background/Aims: The risk of cardiovascular morbidity and mortality is high in patients with diabetes. Since studies suggest that aspirin is less effective in diabetic patients, this study evaluated the prevalence of aspirin resistance and related factors in Korean type-2 diabetics. Methods: All patients taking aspirin 100 mg/day for at least 4 weeks and no other anti-platelet agents were enrolled. The compliance of aspirin intake was determined from patient interviews and using the pill-count method. All other medications were continued during the study, including oral hypoglycemics, antihypertensives, and lipid-lowering agents. The effect of aspirin was assessed using the Ultegra Rapid Platelet Function Assay-ASA (VerifyNow-Aspirin, Accumetrics, San Diego, CA) and aspirin resistance was defined as >550 aspirin reaction units (ARU). Results: The prevalence of aspirin resistance in Korean type-2 diabetics was 14.8%, and was more prevalent in males than in females (28.1% vs. 7.1%). Aspirin resistance was correlated with male sex, smoking, high hemoglobin levels, a high estimated glomerular filtration rate (GFR), and low fibrinogen levels. After controlling for sex, aspirin resistance was related to the estimated GFR (r=0.247, p=0.029), hemoglobin (r=0.23, p=0.043), and fibrinogen (r=0.304, p=0.007) levels. Conclusion: The prevalence of aspirin resistance in Korean type-2 diabetics was 14.8%. Therefore, a laboratory test for aspirin resistance should be considered in diabetic patients taking aspirin to prevent cardiovascular complications. (Korean J Med 76:321-328, 2009)
최준호 ( Jun Ho Choi ),박병현 ( Byoung Hyun Park ),조정구 ( Chung Gu Jo ) 대한내과학회 2008 대한내과학회지 Vol.75 No.5
저자들은 저혈당에 의한 의식 혼미를 주소로 내원, 빈안장증후군과 함꼐 부신피질자극호르몬, 성장호르몬의 감소와 갑상선자극호르몬의 증가를 보인 환자에서 부신피질스테로이드 보충 후 임상 증상의 개선과 정상 월경주기가 회복되었으며 추적 복합 뇌하수체 자극검사에서 성장호르몬의 자극반응이 부분적으로 회복되고 갑상선자극호르몬과 estradiol이 정상화된 1예를 경험하여 문헌고찰과 함께 보고하는 바이다. Isolated adrenocorticotropic hormone (ACTH) deficiency is an uncommon disorder for which the pathogenetic mechanism has not yet been identified. It has been reported that isolated ACTH deficiency (ICD) may be accompanied by deficiencies in other pituitary hormones; impaired growth hormone (GH) secretion was noted in 20 to 30% of ICD patients. Here, we describe a female patient with isolated ACTH deficiency accompanied by empty sella syndrome presenting as hypoglycemia, which was confirmed via various endocrine tests and magnetic resonance imaging (MRI) of the sella turcica. The patient`s symptoms improved rapidly with prednisolone therapy and, during follow-up, her previously impaired GH response to provocative stimuli and high TSH levels were corrected by glucocorticoid replacement alone. However, treatment failed to normalize plasma IGF-1 levels, suggesting that physiological cortisol levels are necessary for a normal plasma GH response to provocative stimuli. (Korean J Med 75:597-601, 2008)
증례 : 내분비 ; 저칼륨혈증성 주기성 마비로 발현된 제2형 당뇨병 1예
염동한 ( Dong Han Yeom ),김하영 ( Ha Young Kim ),박병현 ( Byoung Hyun Park ),조정구 ( Chung Gu Cho ) 대한내과학회 2009 대한내과학회지 Vol.76 No.4
본 저자들은 인슐린 과반응에 의한 고인슐린혈증에 의한 저칼륨혈증성 주기성 마비로 처음 제2형 당뇨병을 진단받은 49세 남자 환자를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Hypokalemic periodic paralysis may be precipitated by stress, rest after exercise, or events that lower serum potassium levels, such as carbohydrate ingestion or the use of insulin or diuretics. In healthy subjects, insulin activates Na+/K+ATPase, which elicits potassium influx and transient hypokalemia; however, hypokalemia is compensated by K+ATP channel activation. Recently, we encountered a 49-year-old male patient with type 2 diabetes mellitus and hyperinsulinemic hypokalemic periodic paralysis. The patient had no family history of muscle weakness or diabetes mellitus. At the time of the attack, plasma glucose was 142.4 mg/dL, plasma insulin was 116. 86 uIU/mL, serum potassium was 2.08 mEq/L, and thyroid hormone, renin, aldosterone, ACTH, and cortisol levels were normal. Symptoms improved rapidly upon potassium replacement. Oral glucose tolerance testing revealed high glucose and insulin levels at 2 h, and serum potassium and phosphate levels decreased from 5.1 to 4 mEq/L and 3.6 to 2.0 mg/dL, respectively. (Korean J Med 76:499-501, 2009)