백서에서 술전 스테로이드 투여에 따른 술후 조직 부종의 변화

김준연(Joon Yeun Kim),이상한(Sang Han Lee) 대한구강악안면외과학회 1990 대한구강악안면외과학회지 Vol.16 No.2

The purpose of this study was to determine the most appropriate time to administer dexamethasone presurgically for reduction of experimental postsurgical edema in rats. Total 105 rats, Spargue Dawley Strain, each weighing about 200-300g, were used and divided into 5 groups: control group consisting of 25 rats; Experimental group 1, 2, 3, 4 were administered dexamethasone(1.5㎎/㎏) intramuscularly just before, 6, 12, 18 hours before operation. Edema was produced by the surgical procedures on the mandibular angle in rats. The obtained results were as follows; The mean percent of water in normal tissue was 74.5%. In control group, mean percent of water increased to 77.4% at the 24 hours, 77.9% at the 48 hours, 80.0% at the 72 hours, and 78.5% at the 96 hours postoperatively. Among experimental groups(group 1, 2, 3, 4), the most effective control of postsurgical edema was observed in group 3 and maximum effect was appeared on 72 hours postoperatively. Histopathologically control group showed greater distortion of architecture with a moderate inflammatory infiltrate and vascular disruption than experimental groups. Experimental group 3 showed much less inflammatory infiltrates than any other groups at 72 hours after operation. In the present study, surgically produced swelling peaked between 48 and 72 hours after injury and could be greatly suppressed by the preoperative intramuscular administration of dexamethasone.

연구개 부위에 발생한 다형성 선종의 외과적 절제후 발생한 Velopharymgeal Insufficiency의 재건술

김진수(Chin Soo Kim),김준연(Joon Yeun Kim) 대한구강악안면외과학회 1989 대한구강악안면외과학회지 Vol.15 No.2

Velopharyngeal insufficiency renders a person incapable of speaking without a noticeable nasality. The emission of excessive air by way of the nasal cavity during speech results in a disturbance in quality and articulatory accuracy of the voice. Velopharyngeal closure is necessary to prevent regurgitation of liquids from the oropharynx into the nasopharynx during deglutition. The most common causes for Velopharyngeal insufficiency are cleft palate, paralysis of the palate, congenital shortining of the palate or excessive depth of the pharyngeal vault due to the basilar skull deformities, or defects in the soft palate. Diagnosis is established by a thorough ear, nose, throat examination, and an audiometric evaluation. Treatment of Velopharyngeal insufficiency consists of speech therapy, dental prosthesis, injections, implants, lengthening of the soft palate(palatal pushback), and posterior pharyngeal mucosal flap. This is a case report of Velopharyngeal insufficiency which was successfully treated with superiorly based posterior pharyngeal flap combined with palatal pushback.

Posterior Maxillay Segmental Osteotomy를 이용한 상악 후방 치조골 과성장의 회복 증례

양성일(Sung Il Yang),김준연(Joon Yeun Kim),김진수(Chin Soo Kim) 대한구강악안면외과학회 1994 대한구강악안면외과학회지 Vol.20 No.1

Thisis a case report of surgical repositioning of unilateral posterior maxillary alveolar hyperplasia by one step posterior maxillary segmetal osteotomy. The patient had masticatory difficulty due to the impinngement on edentulous mandibular posterior alveolar ridge by vertically extruded maxillary posterior teeth. We planned to perform one step posterior maxillary segmental osteotomy to superiorly reposition the extrued posterior maxillary alveolar segment and to recreate enough vertical dimension between upper and lower arch for prosthodontic rehabilitation. After superior repositioning of right posterior maxillary segment, prosthodontic rehabilitation was done on edentulous area of mandibular first and second molars. Therefore, we suggest that one step posterior maxillary segmental osteotomy can be successfully used for correction of unilateral posterior maxillary dentoalveolar hyperplasia.

교근내에 발생한 혈관종의 치험례

이상한(Sang Han Lee),김진수(Chin Soo Kim),장현중(Hyun Jung Jang),김준연(Joon Yeun Kim),김사엽(Sa Yub Kim) 대한구강악안면외과학회 1990 대한구강악안면외과학회지 Vol.16 No.1

Hemangiomas are relatively common tumors which are characterized by a proliferation of blood vessels. These lesions are usually present from birth and are considered by most to be hamartomas rather than true neoplasms. A variant of this entity is the intramuscular hemangioma, a tumor arising within normal skeletal muscle ; these comprise less than 1 percent (0.89) of all hemangiomas. Most intramuscular hemangiomas occur in the trunk and extremities, where there is larger muscle volume. Approximately 10 percents of the lesions occur in the head and neck region. The management of oral and perioral hemangiomas and the mode of therapy employed depend on several factors including the age of the patient, the size and extent of the lesion, as well as its clinical characteristics. Presented is a case report of intramuscular hemangioma on masseter treated with surgical excision combined with microembolization of feeding vassels, right facial artery.

하악 구치부 치주인대에서 발생한 변연성 백악질 섬유종의 치험례 : 증례보고

노충(Chung Noh),최문식(Mun Sik Choi),장도근(Do Geun Jang),김준연(Joon Yeun Kim) 대한구강악안면외과학회 1997 대한구강악안면외과학회지 Vol.23 No.1

Peripheral cementifying fibroma is histomorphologically similar to the central cementifying fibroma, but this lesion is unique to the gingival mucosa and is only rarely seen in edentulous area. In most instances, it arise from interdental papilla, with 80% occurring anterior to molar region. This lesion appears to involve the maxilla and mandible equally, demonstrates the highest occurrence rate during the second decade of life, and affects female more frequently than male, with 4.3:1 to 3:2. Peripheral cementifying fibroma presents as firm, pedunculated or sessile mass with an intact or ulcerated surface depending on the presence of trauma. Microscopically, it reveals a highly cellular mass of connective tissue containing numerous plump, proliferating fibrolasts and several forms of calcification. Effective treatment requires deep excision, which includes the ligament and periosteum, followed by a thorough root scaling of the adjacent teeth. A reveiw of the literature and a report of a case of peripheral cementifying fibroma are presented.

우측 상악동 및 측두하간극에 걸쳐 발생한 선낭포성암의 치험례

장도근(Do Geun Jang),이용규(Yong Gyoo Lee),김사엽(Sa Yub Kim),김준연(Joon Yeun Kim),김진수(Chin Soo Kim) 대한구강악안면외과학회 1993 대한구강악안면외과학회지 Vol.19 No.4

This is a case report of adenoid cystic carcinoma on the right maxillary antrum and infratemporal space. The treatment of adenoid cystic carcinoma is chiefly surgical, although in some case surgery has been successfully coupled with radiation. The patient, aged 52 female, developed a pain involving the right side of face was diagnosed adenoid cystic carcinoma and treated with right tootal maxillectomy, preserving the inferior orbital rim of the right orbit, radical neck dissection performed and postoperative radiation therapy. No recurrence has been observed for 3.9 years. We will examine. Periodically the patient because of its poor prognosis and high recurrence during long term.

Identification of Genes Differentially Expressed in Oral Squamous Cell Carcinoma

김준연 경북대학교치과대학 1995 慶北齒大論文集 Vol.12 No.2

Identification of Genes Differentially Expressed in Oral Squamous Cell Carcinoma

KIM, Joon yeun 慶北大學校 齒科大學 1995 慶北齒大論文集 Vol.12 No.2

암의 형성에 유전자의 구조적 변화가 주된 역할을 하지만 유전자 조절의 변화도 중요한 역할을 한다고 알려져 있다. 본연구는 구강내 악성 편평상피세포종에서 유전자 발현의 변화를 조사할 목적으로 구강내 정상조직과 악성 편평상피세포종 조직에서 376개의 cDNA clone 의 변화를 reverse dot -blot 기법으로 비교하였다 3예의 구강 악성 편평 상피세포종 환자에서 모두 발현이 증가된 유전자는 21 clones는 였다. 이들 21 clones 의 염기서열을 분석하여 Genbank data base 와 homology search를 시행한 결과 이들중 I clone 은 plasminogen activator inhibitor 1 유전자였으며 4 clones는 rat resiniferatoxin-binding protein ,bovine myosin I heavy chain, yeast 4- hydroxybenzoate hexaprenyl transferase 및 human fatty acids omega-hydroxylase 와 염기서열이 유사하였으며 7 clones는 아직 보고되지 않은 유전자이나 Alu repetitive sequence 를 갖고 있었다. 나머지 9 clones는 완전히 새로운 유전자로 밝혀졌다. Using a differential EST screening technique to assay the relative level of expression of each of large numbers of cloned cDNA sequences in oral squamous cell carcinomas, we compared the expression of 376 clones in normal and tumor tissues of oral SCC patients. Comparison of nomal to oral SCCs demonstrated alterations in expression of approximately 5.6% of the cloned sequences. Of 21 cDNA clones which were overexpressed in oral SCCs,one clone was identified as PAI-1(K0377),and four cDNA clones(K0364,K0516,K0595,K0466) revealed homology to genes encoding rat resiniferatoxin - binding protein,bovine myosin heavy chain, yeast 4-hydroxybenzoate hexaprenyl transferase, and human fatty acids omega-hydroxylase, respectively. Seven cDNA clones (K0301,K0312,K0392,K0409,K0442,K0488,K0517)had unknown sequence containing Alu repetitive sequence. Nine cDNA clones (K0055,K0156,K0399,K0491,K0494,K0519,K0529,K0541,K0543) had unknown sequences.