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        • 임프란트시술시 전기자극이 골조직 형성에 미치는 영향

          배창(Chang Bae) 대한치과이식임플란트학회 1991 The Korean Academy of Implant Dentistry Vol.11 No.1

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          It is well known that the electrical current stimulates production or destruction of cell and change the chemical concentration and composition of the soft tissue and bone. These actions vary depending on the microamperage, duration of current, and how to apply to tissue. This experiment was performed to study the effects of electrical stimuli on bone formation in implantation and clinical use in future. I used the Steri-oss implant consisting of commercial pure titanium and New Zealand white rabbit, and delivered the 10± 3jjA, in the control and experimental group which were divided into cathode and anode. Rabbits were sacrificed at the 1st, 2nd and 3rd week after implantation and electrical stimuli. I observed histologically the cellular response and bone formation by light microscope. The results were as follows. 1. There were more new bone formation and osteoblastic activity at the 2nd week than control group at the 1st week. The mature bone formation was focally found at the 3rd week. 2. In experimental cathod group, the most numerous osteoblast and actively proliferating trabecular bone were found at the 1st week. The newly formed trabecular bone at the 2nd week was composed of mature appearing lamellar bone and the thick mature bones were largely present at the 3rd week. 3. No new bone formation was found in experimental anode group, and the foci of necrotic bone was found with increasing time. 4. A little fibrosis was found around the fixture of steri-oss although they were exactly fitted in the hole.

        • KCI등재

          A Roentgenocephalometric Study on the Relationship of His' Line to the Upper and Lower Face

          배창,Bae,,Chang The Korean Academy of Prosthodonitics 1968 대한치과보철학회지 Vol.8 No.1

          저자(著者)는 성장(成長) 발육기(發育期)에 있는 한국인(韓國人)의 His' line과 전두기저선(前頭基底線) 안이평면(眼耳平面) 하악평면(下顎平面) 구개평면(口蓋平面)이 이루는 각도적(角度的) 변화(變化)를 관찰(觀察)하기 위하여 정당교합인(正當咬合人) 남(男) 여(女) 195명(名)의 두부방사선규격사진(頭部放射線規格寫眞)을 Hellma의 치령 분류법(齒齡 分類法)에 의(依)하여 분류(分類)하고 계측(計測) 관찰(觀察)하였든바 다음과 같은 결과(結果)를 얻었다. 1. 성장(成長) 발육기(發育期)에 있어서 전두기저선(前頭基底線)과 His' line이 일정(一定)한 각도(角度) 관계(關係)를 유지한다. 2. His' line은 수평성장축(水平成長軸)으로 생각(生覺)할 수 있다. 3. His' line은 구개평면(口蓋平面)과 대부분(大部分) 일치(一致)하며 남녀(男女)에는 별 차이(差異) 없다. 4. 하악평면(下顎平面)과 His' line이 이루는 각(角)이 심한 것으로 보아 강(强)한 경사도(傾斜度)를 나타내고 있다. 5. 서양인(西洋人)에 비해 하악골(下顎骨)의 후퇴(後退)를 볼 수있다.

        • KCI등재
        • 下顎管이 近接한 下顎左側 回復症例

          이창영(Chang-Young Lee), 배창(Chang Bae) 대한치과이식임플란트학회 1982 The Korean Academy of Implant Dentistry Vol.3 No.1

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          In evaluating the current status of oral implantology, there is frequent reference to the words success and failure. Although there have been reports of failures, there are also many reports of long term retention of dental implant. Ultimate success is dependent upon the choice of implant and prosthetic superstructure, the insertion of a dental implant, and the design and function of the prosthetic appliance. The authors have practiced fixed bridge work after the F.D.B.I.on the lower left free end. saddle area in which mandibular canal is near the alveolar creat instead of the removable partial dentaure. The result have proved to be successful.

        • SCOPUSSCIEKCI등재

          기계적 자극과 interleukin-1ß가 치주인대 섬유아세포의 collagenase와 TIMP-1의 발현에 미치는 영향

          김명립(Myung-Lip Kim), 배창(Chang Bae) 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.1

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          교정력이 치아에 가해지면 치주인대의 재생과 치조골의 개조가 일어난다. 치주인대 섬유아세포는 collagenase와 TIMP-1을 분비하여 치주조직의 교원질의 분해와 합성을 담당한다. 본 연구에서는 치주인대 섬유아세포에 기계적자극과 interleukin-1β를 가해 collagenase와 TIMP-1의 발현을 RT-PCR과 면역조직화학 염색을 사용하여 알아보았다. 4명의 10대 남자 교정환자에게서 아무런 병소가 없는 제 1소구치를 발치후 치주인대 섬유아세포를 배양하여 4-6세대의 세포를 사용하였다. 대조군 Petriperm dish<sup>®</sup> 바닥의 표면적을 5% 증가시킨 기계적 자극을 가한 군, interleukin-1β를 1.0ng/ml를 가한 군과 기계적 자극과 interleukin-1β를 같이 가한 군으로 나누어 4명의 환자에서 얻은 세포군을 각 군별로 2, 4, 8시간 후 RT-PCR을 시행하여 그 산물을 반정량하여 대조군에 대한 각 실험구의 생대적인 증감을 나타내었고, 24시간 후 면역조직화학 염색을 시행하여 다음과 같은 결과를 얻었다. 1. 광학 현미경으로 세포의 형태를 관찰한 결과 대조군에서는 전형적인 별모양과 길쭉한 모양을 함께 보였으나 기계적 자극과 interleukin-1β 를 각각 혹은 동시에 준 군들에서는 별모양의 세포가 사라지고 모양이 더욱 길어졌다. 2. collagenase는 대조군에 비해 기계적 자극과 interleukin-1β를 각각 혹은 동시에 준 군들에서 증가하였고, 실험 8시간 후에서는 interleukin-1β를 준 군, 기계적 자극과 interleukin-1β를 동시에 준 군에서 뚜렷한 증가를 보였다. 3. TIMP-1은 세포 자극 2, 4시간 후에는 대조군에 비해 기계적 자극과 interleukin-1β를 각각 혹은 동시에 준 군들에서 감소하였지만. 실험 8시간 후에서는 증가를 보였다. 4. 면역조직화학 염색을 통해 collagenase와 TIMP-1이 대조군에 비해 기계적 자극과 interleukin-1β를 각각 혹은 동시에 준 군들에서 더욱 강한 염색상을 나타내었다. 본 실험의 결과 섬유아세포는 외부 자극이 가해지면 collagenase와 TIMP-1의 발현 조절을 통해 치주인대 재생과 치조골의 개조에 영향을 미쳐 항상성을 유지하려고 함을 알 수 있었다. The turnover of collagen is controlled by the balance between collagen synthesis and degradation. The production of collagenase (matrix rnetalloproteinase-1). and its inhibitor, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) are onet of the substances which rgulate this balance. The periodontal ligament fibrobIast plays an important role in collagen metabolism during orthodontic treatlment and is believed to be an origin of the osteoblast in the alveolar bone. The collagenase secreted by the periodontal ligament fibroblast and the osteoblast initiates the bone resorption by removing the osteoid layer in the alveloar bone. The interleukin-1β is secreted by the macrophage during orthodontic treatment. The present study was undertaken to assess the effect of mechanical stress and interleukin-1β on the expression of collagenase and TIMP-1 in the periodontal ligament fibroblasts sing reverse transcription polymerase chain reaction and immunohistochemical staining. The periodontal ligament frbroblasts were stretched by placing the Petriperm<sup>®</sup> dish on the top of spheroidal convex watch glass(5%, surface increase) and treated with interleukin-1β (1.0ng/ml), or treated with both of them. Treatrnent with mechanical stress and/or interleukin-1β resulted in increased collagenase mRNA expression. The mechanical stress treated group {161, 1.62, 1.37 fold increase), the interleukin-1β treated group (1.68 1.60 3.78 fold increase), the mechanical stress and interleukin-1β treated group (1.89, 1.72, 5.48 fold increase) induced increases in collagenase mRNA compared with the control group after 2, 4, 8 hours, respectively. But, TIMP-1 mRNA expressions at experimental groups were decreased after 2, 4 hours and increased after 8 hours. The mechanical stress treated group (0.16, 0.49 fold decrease and 3.77 fold incease), the interleukin-1β treated group (0.15, 0.44 fold decrease and 4.46 fold increase), the mechanical stress and interleukin-1β treated group (0.15, 0.69 fold decrease and 4.81 fold increase) induced changes in TlMP-1, mRNA compated with the control group after 2, 4, 8 hours, respectively. Immunohistochemical stain showed that increased collagenase and TIMP-1 staining of the mechanical stress treated group, the interleukin-1β treated group, and the mechanical stress and interleukin-1β treated group compared with that of the control group after 8 hours. These findings suggest that mechanical stress and interleukin-1β regulate expressions of collagenase and TIMP-1.

        • 티타늄과 니켈ᅳ티타늄 합금의 입자들이 생쥐의 복강내 대식세포에 미치는 영향

          황병각(Byung-Gag Hwang), 배창(Chang Bae) 대한치과이식임플란트학회 1990 The Korean Academy of Implant Dentistry Vol.10 No.1

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Titanium has been widely used as an implant material but particles can be liberated from the surface of implant during function and they may be toxic to the adjacent tissue. Nickel - titanium(shape memory) alloy may be not suitable for implant material because of containing toxic nickel. This study was designed to evaluate the effect of particles of titanium and nickel - titanium (Ni-Ti) alloy on mouse peritoneal macrophages. The particle sizes were below 150 jum. Macrophages were cultured at a density of 2X106 cells ml-1 and particles were used at a concentration of 0.025, 0-05 and 0.1 mg m l 1 in Hanks balanced salt solution(HBSS). The cells and particles were incubated for a period of 6,12,24 and 48 hours at 37c respectively. Control group was cultured in the same way without particulate material. Biological effects of these materials were measured by the assay of two enzymes. Lactic dehydrogenase (LDH) released into the supernatant indicates a damage of cell membrane and decreased intracellular level of glucose - 6 - phosphate dehydrogenase(G6PD) indicates a lowered phagocytic activity of the cells. Morphological changes were judged by microscopic examination after staining with hematoxylin and eosin. The results were as follows ; 1. The increase of LDH release towards the end of the culture period was observed in the control and the test groups. The rates of LDH release in test groups, especially in Ni-Ti alloy, were greater than in the control group. Comparatively the LDH release was increased with concentrations in both test groups. But there were no significant differences between the control and the test groups, and in concentrations of the test groups (p)0 .05). 2. A little changes in the activity of G6PD were detected in the control and the test groups with increasing time. The activities of G6PD in tKe test groups were relatively lower than those in the control and were decreased with concentrations in both test groups. But there were no significant differences in the concentrations of the test groups(p〉0.05X). 3. On microscopic examination, it was observed that the macrophages were unaffected by both materials as compared with the control group, and that the cells phagocytosing the small particles of metals were increased in number with time. Some of the cells were degenerated in the control and the test groups at 48 hours. Although titanium and Ni - Ti alloy affected the permeability of the cell membranes and the phagocytic activity of the cells to some extent, they were relatively well tolerated under the test conditions described here. So they may be biocompatible and suitable for implant materials.

        • F.D.B.I.를 利用한 T領両側性 遊離端部位의 回復症例

          한경익(Kyung-Ik Han), 김홍기(Hong-Ki Kim), 배창(Chang Bae) 대한치과이식임플란트학회 1982 The Korean Academy of Implant Dentistry Vol.3 No.1

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Implant dentistry such as blade-vent implant and subperiosteal implant was new science with obscure academic support. But in the 1960's and 1970's,the development of materials with biocompatibility and improved physical properties gave renewed impetus to the use of dental implants. The author placed Free Design Blade Implant on the lower bilateral free-end saddle areas. The following results were obtained. 1. The bilateral blade implant was in good funtion. 2. There were no specific relationships o f the pathologic changes between implant and surrounding structure. 3. Roentgen finding of the operative area showed no trace of abnormality. 4. Patient's mental status were stable & satisfied with appearance.

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