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증상 안정기의 노년기 우울증에서 심혈관 위험과 인지기능 장애 간의 관련성 : 예비연구
황인선(Insun Hwang),임선진(Seon-Jin Yim),이준노(Joon-Noh Lee),송윤영(Yun Young Song),홍경기(Kyungki Hong),홍문화(Moon-Hwa Hong),윤해주(Hai Joo Yoon),엄주란(Jooran Eom) 대한노인정신의학회 2015 노인정신의학 Vol.19 No.2
Objective:The purpose of this study was to test the hypothesis that cardiovascular risk is associated with cognitive impairments in clinically stable late-life depression. Methods:A total of 59 clinically stable late-life depression patients over age 60 were enrolled in a cross-sectional study. Evalu-ation tools used in this study include Hamilton Rating Scale for Depression, Geriatric Depression Scale, State-Trait Anxiety Inven-tory, the Framingham general cardiovascular disease risk profile and the cognitive function battery designed for this study. Corre-lation analysis, analysis of variance and analysis of covariance were performed. Results:Patients with higher cardiovascular risk performed significantly poorer in the domains of executive function and short-term or long-term memory. In models adjusted for age, sex, education, 10% higher cardiovascular risk was associated with poorer executive function. Conclusion:Our findings suggested that cardiovascular risk could be a significant factor associated with poor executive func-tion in clinically stable late-life depression and the management which is necessary as a component of treatment planning. This pi-lot study provided good prospects for future studies to document this relationship on larger samples.