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허영철,김명수,여환호 朝鮮大學校 口腔生物學硏究所 1997 Oral Biology Research (Oral Biol Res) Vol.21 No.1
To study the effect of 3'.5'-cyclic adenosine monophosphate (cAMP) analogs on the growth of cancer cells. 6 cAMP analogs were applied to 3 cancer cell lines (KB, HeLa, CaSki) for 72 hours. Cells were labelled with ^3[H]-thymidine to measure the DNA synthesis which reflects cell growth rate. The growth of cancer cell lines were suppressed by cyclic AMP analogs and the magnitude of the inhibitory effect was different among cancer cell lines. N^6-benzoyl cAMP, 8-bromo cAMP and 8-methylamino cAMP suppressed the growth of KB at the highest concentration used. N^6-benzoyl cAMP, 8-bromo cAMP, 8-methylamino cAMP and 8-(aminohexyl)amino cAMP suppressed the growth of HeLa cell line. 8-bromo cAMP and 8-(aminohexyl)amino cAMP were more effective than other agents. N^6-benzoyl cAMP and 8-bromo cAMP suppressed the growth of CaSki cell line very effectively at concentrations which have very limited suppressive effect on KB and HeLa cell lines. 8-methylamino cAMP and 8-(aminohexyl)amino cAMP also effectively suppressed the growth of CaSki cells. However, 8-chlorophenylthio cAMP suppressed the growth of cancer cell lines at relatively high concentrations. And N^6, O^2-dibutyryl cAMP exerted only limited suppressive effect on the growth of cancer cell lines. In summary, the growth of cancer cells can be suppressed by cAMP analogs and some cAMP analogs can selectively inhibit certain types of cancer cells. The susceptibility of cancer cells to cAMP analogs could be dependent on the activity of intracellular cAMP-dependent protein kinase. Our results prompt the necessity for the development of cAMP analogs which have selective growth inhibitor effect on specific cancer cells for the effective treatment of cancers with minimal toxic effect on normal cells.
정종훈,김수관,허영철 朝鮮大學校 口腔生物學硏究所 1997 口腔生物學硏究 Vol.21 No.2
The Pain is the sensitive and unpresent experience that express the potential tissue injury and, the defence mechanism that warns physiologic disturbance in individuals. There are the method that decrease or releave the pain. including removal of the factor that cause the pain, restrain transferation of impulse, and restrain factor that stimulus the pain. We use the drug theraphy that contain Analgesics, Spasmolytic agents, Vasodilatation agents, Anti-inflammatory agents, and sedative drug. The Pain Control is described with literature review. In severely atrophic or osteoporotic maxilla and mandibles, the location of maxillary sinus and inferior alveolar nerve may vary considerably, both superoinferiorly and mesiolaterally.
박광범,김수관,허영철 朝鮮大學校 口腔生物學硏究所 1997 Oral Biology Research (Oral Biol Res) Vol.21 No.2
The cell that make up the bodies of all but the simplest multicellular animals, both aquatic and terrestrial, exist in an "internal sea" of extra cellular fluid(ECF) enclosed within the integument of the animal. In animals with a closed vascular system, the ECF is divided into 2 components: the interstitial fluid and the circulating blood plasma. The plasma and the cellualr elements of the blood, principally red blood cells, fill the vascular system, and together they constitute the total blood volume. In the average young adult make, 18% of the body weight is protein and related substances, 7% is mineral, and 15% is fat. The remaining 60% is water. The fluid therapy is described with literature review.
박노승,김수관,허영철 朝鮮大學校 口腔生物學硏究所 1997 口腔生物學硏究 Vol.21 No.2
Root from implant are the design most often used in restoration of the partial and complete edentulous patient For success of the implant restoration, Various consideration must be made to design of prosthesis, surgical techniques, oral hygiene care and so on. The desired implant interface at this time is osseointegration, which may be equated to the term rigid osseous fixation. Careful surgical techniques are essential to acquire the osseointegration. The purpose of this article is to enable dental practitioner and oral surgeon to understand the surgical procedures of implant restoration.