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쑥갓의 꽃에서 분리한 sesquiterpene lactones의 항균활성
이경동 ( I Gyeong Dong ),하태정 ( Ha Tae Jeong ),한효심 ( Han Hyo Sim ),장기창 ( Jang Gi Chang ),장대식 ( Jang Dae Sig ),조동령 ( Jo Dong Lyeong ),양민석 ( Yang Min Seog ) 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.3
Thirteen sesquiterpene lactones isolated from the flower of Chrysanthemum coronarium L.. which has been widely cultivated in Korea as a vegetable for a long time, were investigated their antimicrobial activities against eight bacteria and five phytopathogenic fungi. The antimicrobial activities of dihydrochrysanolide (6) and 1-epi-dihydrochrysanolide (7) showed strong activities against all the bacteria such as Bacillus subtilis, Bacillus cereus, Staphylococcus aureus and Vibrio parahaemolyticus. Especially, Staphylococcus aureus was investigated that have very strong antibacterial activity to 1.56 ㎍ㆍdisc^(-1), respectively. Also, most of sesquiterpene lactones, which have α-methylene-Y-butyrolactone group, were exhibited strong activity to Gram(+) bacteria than Gram(-) bacteria. In the antifungal test, Rhizoctonia solani and Phytophthora capsici known as phytopathogenic fungi have exhibited all extensive activity about compounds that have α-methylene-Y-butyrolactone group.