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이돈일,유재신,범진필,최준식 ( Do Nil Lee,Jae Sin You,Jin Pil Burm,Jun Shik Choi ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
N/A This study was attempted to investigate the pharmacokinetic interaction of vancomycin (10 ㎎/㎏, i.v.) and probenecid (7.5, 15, and 30 ㎎/㎏, oral) in rabbits. The area under curve (AUC) of plasma vancomycin concentration was significantly increased (p<0.01) in rabbits when the probenecid was coadministrated. Volume of distribution (Vd) was significantly decreased (p<0.05) in rabbits coadministrated with probenecid (15 and 30 ㎎/㎏) and total body clearance (CLt) was decreased significantly (p<0.05, p<0.01) in rabbits coadministrated with probenecid (7.5, 15 and 30 v). There was significant correlation between AUC and probenecid dose. From the results of this experiment, it is desirable to adjust dosage regimen of vancomycin for reduction of side or toxic effect when the probenecid is coadministered in clinical practice.
이돈일,유재신,최준식 朝鮮大學校 1998 藥學硏究誌 Vol.19 No.2
This study was attempted to investigate the pharmacokinetic interaction of vancomycin (10 mg/kg. i.v.) and probenecid (7.5. 15. and 30 mg/kg. oral) in rabbits. The area under curve (AUC) of plasma vancomycin concentration was significantly increased (P<0.01) in rabbits when the probenecid was coadministrated. Volume of distribution (Vd) was significantly decreased (p<0.05) in rabbits coadministrated with probenecid (15 and 30 mg/kg) and total body clearance (CLt) was decreased significantly (p<0.05. p<0.01) in rabbits coadministrated with probenecid (7.5. 15 and 30 mg/kg). There was significant correlation between AUC and probenecid dose. From the results of this experiment. it is desirable to adjust dosage regimen of vancomycin for reduction of side or toxic effect when the probenecid is coadministered in clinical practice.