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MCF-7 세포주에서 γ선에 의한 세포신호 전달 관련 유전자의 발현 양상의 분석
박지윤 ( Park Ji Yun ),황창일 ( Hwang Chang Il ),박웅양 ( Park Ung Yang ),김진규 ( Kim Jin Gyu ),채영규 ( Chae Yeong Gyu ) 한국환경생물학회 2003 환경생물 : 환경생물학회지 Vol.21 No.1
N/A There is considerable evidence that ionizing radiation (IR) mediates checkpoint control, repair and cell death. In this study, we have used a high density microarray hybridization approach to characterize the transcriptional response of human breast carcinoma MCF-7 cell line to y-radiation, such as 4 Gy 4 hr, 8 Gy 4 hr, and 8 Gy 12 hr. We found that exposure to γ-ray alters by at least a logs factor of 1.0 the expression of 115 known genes. Of the 66 genes affected by ^-radiation, 49 are down-regulated. In our results, the cellular response to irradiation includes induction of the c-jun and EGRI early response genes. The present work has examined potential cytoplasmic signaling cascades that transduce IR-induced signals to the nucleus. 40S ribosomal protein s6 kinase modulates the activities of the mitogen activated protein kinase (MAPK) and c-Jun NH₂-terminal kinase (JNK1) cascades in human monocytic leukemia (U937/pREP4) cells. 14-3-3 family members are dimeric phosphoserine-binding proteins that participate in signal transduction and checkpoint control pathways.