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鄭澤相 충남대학교 의과대학 지역사회의학연구소 1979 충남의대잡지 Vol.6 No.2
Osmotic fragility of RBC was observed in pregnant women(normal and toxmia) and fetuses. And studied in NaCl solution(0.3, 0.35, 0.4, 0.45, 0.5, and 0.55%) and degree of hemolysis was measured with sphectrophotometer at 540mμ. The results are as follows : 1. The osmotic fragility in NaCl solution was increased in pregnant woman and fetus than that of the non-pregnant woman. Especially, this differences were statistically significant in 0.45 and 0.5% of NaCl solutions. 2. Concentration of NaCl solution of 50% hemolysis was increased than that of nonpregnant woman as following oders : toxemic pregnant woman, fetus of normal pregnancy, normal pregnancy, and fetus of toxemic pregnancy. 3. The RBC of the toxemic pregnant woman was less fragile than that of the normal pregnant woman.
정택상,강길전 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.1
The effecs of hydrogen ion concentration changes on the contractility as well as patterns of contraction to hormones were investigated in the isolated rabbit uterine muscles. Contractility was recorded on a Physiography with force transducer by means of Magnus method in sodium lacate Ringer's solution used were normal (pH 7.4), acidic (pH 6.3), and alkaline (pH 9.4), were titrated by 0. 01 N HCI or 0. 01 N NaOH solution respectively. Used hormones and its doses were 0.1ug/ml epinephrine, 50 mu/ml oxytocin, 30ug/ml and 100 pg/ml prostaglandin F_2a and prostaglandin E_2. Obtained results are summerized as follows: 1. Increased hydrogen ion concentration inhibited the contractility of uterine muscle, and dereased concentration increased the motility. 2. Decreased hydrogen ion from pH 7. 4 to pH 9. 4 increased the tension of the uterine contraction to 215±40%. 3. Epinephrine increased the uterine contractility in each pH. In pH 7. 4, the contraction tension of the uterine muscle was increased to 510±65% of the control value, but in pH 6.3 and 9.4, increased contraction tension were significantly lower than pH 7. 4 (p<0.01). 4. The increased contraction tension of oxytocin in pH. 7.4 was 197±25% of the control value In pH 6. 3, the increased contraction tension was significantly lower than pH 7. 4 (p<0.01), but in pH 9.4, the increased contraction was significantly higher (p<0.01). 5. Prostaglandin F2α and E2 increased the contraction tension to 305±34% and 391±73% in pH7. 4. But in pH 6. 3 and 9.4 were lower increased than pH 7.4(p<O.01).