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트롬복산 수용체 활성화가 인터루킨-8 발현에 미치는 영향
전화진(Hwa-Jin Jeon),김수륜(Su-Ryun Kim),박현주(Hyun-Joo Park),김미경(Mi-Kyoung Kim),김도원(Do-Won Kim),배수경(Soo-Kyung Bae),배문경(Moon-Kyoung Bae) 한국생물공학회 2013 KSBB Journal Vol.28 No.1
Thromboxane A₂ (TXA₂) is one of major proinflammatory mediators, plays an important role in the development of vascular inflammatory diseases. TXA₂ acting through the thromboxane receptor regulates multiple pathways and genes in a variety of cells. In this study, we report that the activation of thromboxane receptor with U46619 increases the interleukin-8 (IL-8) mRNA in vascular endothelial cells. We also demonstrated that U46619 produces the activations of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK), which is required for endothelial IL-8 production. And U46619 enhanced mRNA stability of IL-8 transcripts in endothelial cells. Moreover, inhibition of ERK1/2 or p38MAPK reduced monocyte adhesion to aortic endothelium stimulated by U46619. Therefore, these results suggest that activation of thromboxane receptor promotes the expression of IL-8 via ERK1/2 and p38MAPK activation in endothelial cells.