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근위축 유도 후 운동에 따른 아폽토시스 관련 유전자 연구
김재호(Jea-Ho Kim),이동복(Dong-Bok Lee),김용안(Yung-An Kim),전용균(Yung-kyun Jeon) 한국생활환경학회 2009 한국생활환경학회지 Vol.16 No.3
This study purposed to prove the effect of exercise after induction muscle atrophy related Apoptosis gene Bcl-2 m-RNA, Bax m-RNA, Caspase-3 m-RNA We classified the mice(ICR) after induction muscle disuse atrophy into 2 groups: exercise(20 mice) and non-exercise(20 mice). the analysis point of view which if follows is stability, one day, three day, five day, seven day and each testing group three mice cervical decapitation which will burn the killed related apoptosis gene the Bcl-2 m-RNA expression showed a significant statistical difference in non -exercise group'1st day and 7st day(p<.001, p<.01). There was a significant difference in exercise group'5st day(p<.01). The Bax m-RNA expression showed a significant statistical difference in non -exercise group'3st day and 7st day(p<.001). When stabilized, there was little significant difference in non -exercise group'1st day and 5st day. The Caspase-3 m-RNA expression showed a significant statistical difference in non -exercise group'3st day, 5st day and 7st day(p<.001). When stabilized, there was little significant difference in non -exercise group'1st day. It could be inferred from the results of the study that a steady in crease load training method can be more effective than continued stability after patients who have the muscle atrophy which appear from an accident or a bed safety muscular power exercise insufficiency treat. Bcl-2 m-RNA expression that inhibits cell death didn't have much effect. But, Bax, Caspase-3 m-RNA that promotes cell death showed a significant statistical increase.
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