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중환자실 환자의 정맥주사용 글루타민 투여에 따른 임상효과 평가
김광준 ( Kwang Joon Kim ),장혜영 ( Hey Young Jang ),강민구 ( Min Ku Kang ) 한국정맥경장영양학회 2019 한국정맥경장영양학회지 Vol.11 No.1
Purpose: To evaluate the clinical effect of intravenous glutamine administration on patients admitted to the intensive care unit in general hospitals. Methods: Patients with more than 7 days in an intensive care unit were evaluated. The experimental group was the patients who received intravenous glutamine administration for more than 3 days. The laboratory results, intensive care unit length of stay, hospital length of stay, 30 days mortality, and hospital mortality were evaluated with a comparative group. Results: The mean number of administration days of intravenous glutamine was 10.12±8.93 days, and the average daily dose was 0.33±0.10 g/kg/day. No adequate improvement in the laboratory results of glutamine-treated group was observed. The intensive care unit length of stay (21.16±15.83 vs. 16.48±11.06, P=0.007), hospital length of stay (35.94±30.75 vs. 27.34±19.09, P=0.010), 30 days mortality (20.0% vs. 10.0%, P=0.034), and hospital mortality (26.3% vs. 13.0%, P=0.001) were higher in the glutamine-treated group. Conclusion: The use of intravenous glutamine on intensive care unit patients did not improve the clinical effect. Further large-scale multi-center studies will be needed to assess the proper administration of intravenous glutamine on intensive care unit patients.
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