柴胡의 藥理學的 硏究(I) : 血壓 및 深博에 對하여

李世珪,林東潤 順天鄕大學校 1980 의대논문집 Vol.5 No.-

This study was attempted to investigate the pharmacological action on blood pressure and heart rate in the urethane-anesthetized rabbits, making use of bupleuri radix methanol extract(BRME). BRME, when administered into a ear-vein of rabbit, produced a fall in blood pressure and diminished heart rate. Dose-response curve by increasing dosage of intravenous BRME was established in changes of blood pressure and heart rate. Accumulation and. tachyphylaxis in hypotensive action by BRME were not observed. Depressor action of BRME was not influenced by pretreatment with chlorisondamine, guanethidine, phentolamine, diphenhydramine, cyproheptadine and propranolol. This hypotensive response of intravenous BRME was not inhibited by vagotomization and pretreatment of hemicholinium, but weakened markedly by atropine-treatment, and potentiated significantly by physostigmine. Intravenous BRME markedly suppressed cardioaccelerating action of isoproterenol, but did not affect action of norepinephrine. With the above results, it is concluded that depressor action by intravenous BRME is due to the peripheral cholinergic effect(muscarinic action) and BRME also reduces heart rate by inhibition of beta-adrenoceptor.

Nitroblue-Tetrazolium 還元試驗의 診斷的 意義

李世圭 고려대학교 의과대학 1973 고려대학교 의과대학 잡지 Vol.10 No.1

柴胡의 藥理學的 硏究 (Ⅰ) : 血壓 및 心搏에 對하여 On Blood pressure and Heart rate

李世珪,林東潤 朝鮮大學校 醫學硏究所 1980 The Medical Journal of Chosun University Vol.- No.-

This study was attempted to investigate the pharmacological action on blood pressure and heart rate in tile urethane-anesthetized rabbits, making use of bupleuri radix methanol extract (BRME). BRME, when administered into a ear-vein of rabbit, produced a fall in blood pressure and diminished heart rate. Dose-response curve by increasing dosage of intravenous BRME was established in changes of blood pressure and heart rate. Accumulation and tachyphylaxis in hypotensive action by BRME were not observed. Depressor action of BRME was not influenced by pretreatment with chlorisondamine, guanethidine, phentolamine, diphenhydramine, cyproheptadine and propranolol. This hypotensive response of intravenous BRME was not inhibited by vagotomization and pretreatment of hemicholinium, but weakened markedly by atropine-treatment, and potent- iated significantly by physostigmine. Intravenous BRME markedly suppressed cardioaccelerating action of isoproterenol, but did not affect action of norepinephrine. With the above results, it is concluded that depressor action by intravenous BRME is due to the peripheral cholinergic effect(muscarinic action) and BRME also reduces heart rate by inhibition of beta- adrenoceptor.

Dylan Thomas의 詩的 에너지 : 죽음의 극복을 주제로

李世珪 檀國大學校英美文化硏究所 1983 英美文化 Vol.2 No.-

Pound once said: "Great literature is simply language charged with meaning to the utmost possible degree". Pound's concise description reflects not only upon the achievements of the past but upon experiments undertaken in the present century. Pound's is susceptible of various interpretations depending upon where one directs the falling stress. Perhaps it is true to say that most modern experimental poets have been preoccupied with the charge of language, the energy with which meaning conveyed. The aesthetic problem sleeping in Pound's statement can give access to the poetry of Dylan Thomas. This paper aims to examine the contasted aspect of energy revealed in the earlier poetry with the later's of Dylan Thomas. dylan Thomas once descried his poetry as a record of passing from darkness into some measure of light. This represents a indication that he aims to quest for poetic identity by means of the poetry; he gropes for it in a round about way through the process of overcoming death. In the earlier poetry, he attempts to come to terms with death on the basis of "the principle of Process," identifying death with life. As a result, a single force which is creative and destructive as the same time unifies the poet with the natural environment. Therefore, the earlier poetry can be said to register the regularity of destructive and creative force; pulsation, systole and diastole, inhalation and exhalation. but in the later poetry, he tries to come to terms with death through the energetic love and belief; love and belief becomes agents subduing the conflict between poetic vision and realistic awareness. This is the reason why poetic energy becomes condensed on the image of love and belief; why it becomes visible as suddenly as an open artery.

Seamus Heaney의 고고학적 상상력 : 민족주의와 시 Nationalism and Poetry

이세규 檀國大學校英美文化硏究所 1997 英美文化 Vol.6 No.-

Seamus Heaney is known to be the most important Irish poet since W. B. Yeats. The concern about his work by distinguished critics and fellow poets in Britain and America, as well as Ireland measures the degree of his reputation. I assume that a growing interest among Korean readers reflects this prevailing enthusiasm for his work. His method and ideas owe more to the nineteenth rather than the twentieth century. This seems to be an attractive factor to draw a reader's attention. In fact, His poetry has the proper qualities to absorb the devotees of 'practical criticism' still dominant in class of dealing with the poetry. However, we cannot fail to see that his poetry is lacking inspiration to exalt our mind, which is structured on a formalized pattern. In other words, he approaches his subject in an easy way. The main subject of his poetry is to reconcile his individuality with the community. This subject is linked with the question to fill the sectarian rift between the Catholic community and the Protestant's in Ireland. It appears that his poetry is involved in this question. He seems to express his integrity by the degree to which he identifies himself with and integrates his difference in a national consciousness. This aspect makes some critics believe that Heaney surrenders his individuality to identify with the spirit of his community. Their opinions are not different from defining him enthusiastic nationalist. But he grew up in the Northern Ireland, part of the United Kingdom, which technically at least makes him British. Only this fact is enough to raise doubts about their opinions. Based on this premise, this paper aims to prove that though his individuality as a poet is united with the spirit of his Catholic community, its independent value is still preserved. In this respect, presumablely he is influenced by G. M. Hopkins. Hopkins was a priest and a poet. In sensical terms, it seems to be impossible for him to be faithful to his two vocations at the same time. Notwithstanding, he could find a clue to do so from the theology of Duns Scotus. Scotus's main distinction from the traditional theology was his belief in 'the principle of individuation.' All medieval philosophers were concerned with how human being could come to know the universal. Scotus believed that human beings could find God by apprehending each individual object's essence. Hopkins also could make his two vocations compatible by employing hi sensitivity to beauty to lead him to God. It is my conclusion that Heaney, in the same method, became unified with the spirit of his community through his archeological imagination, being employed to find historical sense in the past. Here, we can find his homogeneity and disparity with his community placed in juxtaposition. We cannot be freed from suspicion that he depends on this manneristic method to reconcile his individuality as a poet with the spirit of the community.

β-Adrenalin 作用藥物이 水利尿에 미치는 影響 1

李世圭 고려대학교 의과대학 1977 고려대학교 의과대학 잡지 Vol.14 No.1

β-Adrenalin 作用藥物이 水利尿에 미치는 影響

李世圭,洪淳國 고려대학교 의과대학 1977 고려대 의대 잡지 Vol.14 No.1

The infusion of isoproterenol has been shown to decrease urine volume and free water clearance without altering glomerular filtration rate and without altering or moderately increasing renal plasma flow. It was reported that isoproterenol increase water permeability on toad bladder by similar action of antidiuretic hormone. Recent findings that increased water permeability induced by isoproterenol was inhibited by propranolol, but not by antidiuretic hormone indicate that renal beta adrenergic receptors mediate the increase of water permeability induced by isoproterenol. It was well recognized that norepinephrine, the principal endogenous alpha adrenergic agent, produces constriction of renal arteries and vasa recta. It was also showed that in kidneys vasodilated with acetylcholine infusion of norepinephrine caused natriuresis while on the opposite, nonvasodilated kidney, sodium excretion decreased. Constriction of vasa recta reserve the medullary osmotic gradient and renal concentrating ability, on the contrary dilation of vasa recta abolish the medullary osmotic gradient and renal concentrating ability. The present study was designed to examine the effects of isoproterenol on renal function in the rabbit and to determine if these effects are related to changes in renal hemodynamics. On experiments 20 rabbits were infused with 2.5% dextrose solution until water diuresis were maintained and thereafter simultaneous administration of isuprel (0.1㎍/㎏/min), and then isuprel (0.1㎍/㎏/min) plus noradrenalin (0.5㎍/㎏/min) were performed. During experiments urine volume, C_(IN), Cosm, C_(H2O), sodium excretion and C_(PAH), E_(PAH), RPF, FF, NCPF were measured for four consecutive specimens every twenty minutes intervals. The results were as follows: 1) Total renal plasma flow, cortical plasma flow, filtration fraction and medullary plasma flow were not altered by administration of water, isuprel and noradrenalin. 2) Water diuresis was inhibited by isuprel, while isuprel antidiuresis was inhibited by noradrenalin. 3) Glomerular filtration rate, osmolar clearance and sodium excretion were not altered by water loading, isuprel and noradrenalin.

槿 花 希 望

李世圭 전국한자교육추진총연합회 2025 한글+한자 문화 Vol.310 No.0

오가피(五加皮) Ethanol Extract의 실험적(實驗的) 신성고혈압(腎性高血壓)에 미치는 영향(影響)

이세규,고석태,임동윤,Lee, Sae-Kyu,Ko, Suk-Tai,Lim, Dong-Yoon 한국약제학회 1978 Journal of Pharmaceutical Investigation Vol.8 No.3

This study was carried out for the purpose of observing the effect of Korean Acanthopanax Radicis Cortex on renal hypertension and to clarify the mechanism of this effect, making use of its ethanol extract. Adult male or female rats, weighing 180-250g, were divided into 3 groups; the first for normotensive control, the second for hypertensive control and the third for hypertensive Acantopanax-treatment. Rats in the normotensive and hypertensive control group were administered 0.9% saline subcutaneously only, whereas those in the Acanthopanax-treated hypertensive group were administered 50mg/kg Acanthopanax ethanol extract subcutanously once a day. Changes of original blood pressure, and responses of blood pressure to various 4gents(norepinephrine, angiotensin, acetylcholine, serotonin and histamine) were recorded for each group on the initial, 18th, 32nd and 46th days of the experiment. The results obtained in this experiment are as follows: 1) The initial blood pressure was $102.6{\pm}7.6mmHg$ on the average. The blood pressures of the normotensive control group were not observed to alter significantly at any period in the course of the experiment. 2) The mean blood pressures in the hypertensive control group were recorded at $120.3{\pm}10.4mmHg$ on the 18th day, at $134.5{\pm}9.2$ on the 32nd day and at $138.8{\pm}8.3$ on the 46th day, thus revealing significant elevation in comparison with the corresponding normotensive control group blood pressures. On the other hand, the mean blood pressures in Acanthopanax-treated hypertensive group on the 18th, 32nd and 46th days were $118.3{\pm}9.7,\;129.9{\pm}8.3\;and\;120.2{\pm}8.3mmHg$ respectively. The blood pressures of the hypertensive-Acanthopanax group recorded. on the 46th day revealed a significant difference as compared with those of the corresponding hypertensive control group. 3) On the 46th day of this experiment, the responses of blood pressure to acetylcholine in the hypertensive-Acanthopanax group were suppressed significantly as compared with those of the hypertensive control group, and in the latter group, angiotensin was decreased markedly as compared with the corresponding normotensive control group. In contrast, pressor action of norepinephrine and depressor action of serotonin and histamine did not differ significantly among the three groups. These results suggest that Acanthopanax ethanol extract suppresses the induction of renal hypertension by means of a cholinergic action such as that caused by acetylcholine.

향정신성약물(向精神性藥物)이 뇌(腦) amine 함량(含量) 변동(變動)에 미치는 영향(影響)(제 1 보고)(第 1 報告)

이세규,김혜성,Lee, Se-Kyu,Kim, Hei-Sung 대한약리학회 1970 대한약리학잡지 Vol.6 No.1

The present study is concerned with the demonstration of the relationship between the behavior and the brain concentration of noradrenaline resulted from pretreatment of amphetamine in isolated or aggregated rats. The experimental subjects were rats weighing from 120g to 200g housed 1, 2, and 6 in a cage. Analeptic activity of amphetamine was measured by determining the sleeping time induced by pentobarbital sod. The noradrenaline content in brain was determined with Aminco-Bowmann's spectro-photofluorometer by Lee's modification of Shore and Olin method. Results: 1) The analeptic activity of amphetamine on the sleeping time induced by pentobarbital sod. was more increased in the grouped rats than in isolated animal. 2) In being isolated and grouped rats, the sleeping time induced pentobarital sod, was markedly prolonged by pretreatment of amphetamine. 3) Means of housing rats, e.g., isolation or aggregation did not seem to affect the brain noradrenaline depleting action. 4) Repeated daily parenteral administration of amphetamine sulfate for a period 1 to 3 weeks resulted in decrement of brain noradrenaline concentration in being isolated and grouped rats. 5) The prolongation of sleeping time of the isolated or aggregated rats, when pretreated with amphetamine, compared with that of stock rats, seems to be attributable rather to the means of housing than the variation of the noradrenaline caused by amphetamine.