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Teik Hin Tan,이분낭,Siti Zarina Amir Hassan 대한핵의학회 2014 핵의학 분자영상 Vol.48 No.3
Purpose In neuroendocrine liver metastases of unknown primary,a multimodality approach is usually adopted and consistsof transabdominal ultrasound, endoscopic ultrasound(EUS), computed tomography (CT), magnetic resonance imaging(MRI), nuclear medicine techniques, endoscopy andexploratory surgery. The purpose of the study is to evaluatethe diagnostic value of 68Ga-DOTATATE positron emissiontomography (PET)/CT as part of a multimodality approach inneuroendocrine liver metastases of unknown primary. Materials and Methods Six patients (M:F=5:1, age range 28–56 years) with immunohistochemically proven neuroendocrineliver metastases but inconclusive initial CT work-upwere retrospectively analysed. Clinical finding, histopathology,comparative imaging and follow-up were used to validatethe results when ethically justified. Results 68Ga-DOTATATE PET/CT identified the primarytumour in five out of six (83.3 %) patients: pancreas (n =4)and stomach (n =1). Out of three patients with indeterminateprimary on initial CT, two patients were confirmed by 68Ga-DOTATATE PET/CT. Absence of uptake in indeterminateprimary of one patient was later confirmed negative by histopathology. In another three patients with undetected primaryon initial CT, primary site was demonstrated in all patientswith unsuspected metastases in two patients on 68Ga-DOTATATE PET/ CT. No further work-up was done to confirmthe primary in patients with distantmetastases. Change ofmanagement was observed in three out of six (50 %) patients. Conclusion Our small study indicates that 68Ga-DOTATATEPET/CT is a promising diagnostic option in the multimodalityapproach to neuroendocrine liver metastases of unknownprimary origin.
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