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RISS 인기검색어
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- 저자 : 윤동환(Dong-Whan Yoon) (검색결과 3 건)
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치주조직 유관세포에서의 Nitric Oxide 및 Nitric Oxide Synthetase의 생물학적 특성에 관한 연구
윤형진,윤동환,유형근,신형식,Yoon, Hyung-Jin,Yoon, Dong-Whan,You, Hyung-Keun,Shin, Hyung-Shik 대한치주과학회 1997 Journal of Periodontal & Implant Science Vol.27 No.4
Bone remodeling is characterized by the coupling of osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The process is tightly regualted at the local level by an incompletely known netwotk of peptide and non-peptide fators. Nitric oxide(NO), synthesized by nitric oxide synthetase(NOS) from L-arginine, is becoming recognized as an important bioregualtory molecule in a variety of tissue, but little is known about its possible role in periodontal tissue. The purpose of this study is to investigate the expression of nitric oxide synthetase(NOS) in inflamed gingiva and the effects of cytokine on the expression of NOS protein. The expression of NOS in gingival tissue was evaluated by immunohistochemical staining for $NOS_1$, $NOS_2$, $NOS_3$. The effect of cytokine on the expression of NOS in human periodontal ligament cells and osteoblast-like HOS cells by western blot analysis. Further, we studied that NO functions in periodontal ligament cells as a regulatory molecule. PDL cells incubated with NOS inhibitor and donor. The protein expression, type I collagen & non-collagenous protein, nitrate production and cell proliferation were evaluated The results were as follows. 1. $NOS_1$, $NOS_2$, $NOS_3$ was rarely distributed in healthy gingiva, but stronger stained in gingival epithelium, endothelial cells, and mononuclear cells of inflammed gingiva. 2. The cytokine stimulated $NOS_1$, and $NOS_3$ protein were not inducing or inhibitory effect to compared with control in PDL and HOS cells. 3.Incubation of cells with combination of $TNF-{\alpha}$, $IFN-{\gamma}$, LPS result in a time dependant increase in $NOS_2$ expression, reaching a maximal level after 24 hours of stimulation. 4. The osteonectin protein inhibitory effect of NMA, inhibitor of NOS, was reversed by Larginine in dose dependant manner. 5. NMA decreased cell poliferation and nitrate production, but the inhibitory efffect of NMA was also prevented by the NO donor, sodium nitropruiside. These results suggest that exogenously synthesized NO was playing a stimulating effect on cell proliferation or on non-collagenous protein expression. Therefore NO have an important role in mediation of localized bone destruction associated inflammatory bone disease such as periodontitis.
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INCONEL 690 합금의 고온 프레팅 특성에 관한 연구
정한규(Han-Kyu Jeung),윤동환(Dong-Whan Yoon),박대규(Dae-Kyu Park),권재도(Jae-Do Kwon) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.11
In this study, fretting fatigue test of INCONEL alloy 690 caused which is currently using the steam generator tube of nuclear power plants. this factor has carried out in high temperature of 320℃, As a result of all these factors will be compared and analyzed between the fretting fatigue results of room temperature and the normal fatigue test results of high temperature atmosphere. Through the friction force of contact area for rep eat cycle, to the effect that result are analyzed in high temperature atmospheres. The high temperature fretting fatigue mechanisms are analyzed with observation of a fracture surface and we make an estimate of the structural stability of a nuclear p ower plants in a practical working temperature.
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최적화 화소 기반 형태분석 방법을 이용한 알츠하이머 병환자의 회백질 용적감소의 정량적 분석
임현국(Hyun Kook Lim),윤동환(Dong Whan Yoon),원왕연(Wang Youn Won),이철(Chul Lee),이창욱(Chang Uk Lee) 대한노인정신의학회 2009 노인정신의학 Vol.13 No.1
Objective : Optimized voxel based morphometry (VBM) has been increasingly applied to investigate differences in brain morphology between a group of Alzheimer's Disease (AD) patients and control subjects. Optimized VBM permits comparison of gray matter (GM) volume at voxel-level from the entire brain. The purpose of this study was to assess the regional GM volume loss measured by optimized VBM in AD compared to controls Methods : Twenty-three AD patients and 20 cognitively normal elderly control subjects included in this study. To improve the VBM performance, the study specific template and the probability maps were generated from the control subjects. Results : Optimized VBM analysis revealed GM loss, including hippocampus, amygdala, anterior cingulate, posterior cingulate, insula, frontal lobe and middle temporal complex in the AD group as compared to normal control group Conclusion : The VBM results confirmed previous findings of temporal lobe and limbic lobe atrophic changes in AD, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution.
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