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유지숙 ( Jisook Yoo ),안효상 ( Hyosang Ahn ),김민수 ( Min-soo Kim ),주민숙 ( Mihn-sook Jue ),최광현 ( Kwang Hyun Choi ) 대한피부과학회 2017 대한피부과학회지 Vol.55 No.5
Background: Tranexamic acid (TXA), a plasmin inhibitor, has been used orally or via intradermal injection to treat melasma; however, there are limited studies regarding efficacy and safety of topical application of TXA. Objective: The purpose of this study is to evaluate the efficacy and safety of topical tranexamic acid in treatment of melasma. Methods: We enrolled 25 female volunteers with melasma in a split-face trial lasting 10 weeks. Patients were instructed to apply cream containing tranexamic acid on only the right side of their face every night without application on the other side. The pigmentary index (PI) using API-100 and Melasma Area and Severity Index (MASI) were measured at 0, 5, and 10 weeks. Patient satisfaction questionnaires and safety evaluation by a dermatologist were performed at each follow-up visit.== Results: Twenty-five patients completed the study, and we noted reduction in both, mean MASI and PI scores. The mean MASI score was 7.75±5.10 at baseline, 6.72±4.25 at week 5, and 6.26±3.76 at week 10 p=0.008). The mean PI score on the right side of the face was 40.56±22.51 at baseline, 29.96±16.62 at week 5, and 26.88±15.97 at week 10. The PI on the right side of the face decreased by 26.1% (p<0.001) at week 5 and 33.7% (p<0.001) at week 10 compared to the baseline. Mean PI score on the unaffected side of the face was 40.56±22.60 at baseline, 37.48±17.79 at week 5, and 34.68±16.44 at week 10, although this reduction was not statistically significant (p=0.146). Only mild irritation occurred in two patients, no other serious adverse events were noted, and patients were generally satisfied with their results. Conclusion: Topical TXA can be considered a safe and effective option in the treatment of melasma. (Korean J Dermatol 2017;55(5):283∼289)
허준원 ( Joon Won Huh ),유지숙 ( Jisook Yoo ),김민수 ( Min Soo Kim ),최광현 ( Kwang-hyun Choi ),박향준 ( Hyang-joon Park ),주민숙 ( Mihn-sook Jue ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.10
Segmental neurofibromatosis is a rare form of neurofibromatosis that is characterized by neurofibromas and/or cafe au lait macules, limited to one region of the body. The neurofibromas of segmental neurofibromatosis are most commonly occupied by either a cervical or a thoracic dermatome. Segmental neurofibromatosis on the face is extremely rare, and only 10 cases have been described so far. Herein, we report a case of segmental neurofibromatosis on the V1 dermatome for its rarity and unusual location. (Korean J Dermatol 2016;54(10):811∼813)
이마의 Blaschko 선을 따라 발생한 경화 위축성 태선
조민결 ( Mingyul Jo ),박은정 ( Eunjung Park ),유지숙 ( Jisook Yoo ),이미지 ( Mi-ji Lee ),김민수 ( Min-soo Kim ),최광현 ( Kwang-hyun Choi ),주민숙 ( Mihn-sook Jue ) 대한피부과학회 2018 大韓皮膚科學會誌 Vol.56 No.8
Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory dermatosis presenting as white papules and atrophic patches in the anogenital region. Extragenital LSA is rare and commonly affects the neck, thighs, and the trunk. A 68-year-old woman presented with a well-demarcated, whitish linear plaque on the forehead that was observed several months prior to presentation. A biopsy specimen showed hyperkeratosis and thinning of the epidermis and homogenization of collagen in the papillary dermis with a subepidermal cleft. Mild periappendageal lymphocytic infiltration and eccrine gland atrophy secondary to thickening of collagen bundles were observed in the deep dermis. Based on the clinical and histopathological findings, this patient was diagnosed with extragenital LSA and concomitant morphea along the Blaschko’s lines. (Korean J Dermatol 2018;56(8):485∼488)