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표피 Tight Junction 단백질 중 Occludin의 신체 부위별 발현도에 대한 연구
유서례 ( Seo Rye Yoo ),김지숙 ( Ji Sook Kim ),고주연 ( Joo Yeon Ko ),이창우 ( Chang Woo Lee ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.2
Background: ``Tight junctions (TJ)`` have recently been identified in the granular cell layer of the human epidermis, where they contribute to the normal adhesion between keratinocytes and to the physiologic barrier function of the epidermis. Among the TJ proteins in the epidermis, occludin is an important transmembrane protein, which is considered as a major component among the TJ. Objective: The purpose of this study is to investigate whether regional variation exists in the expression of tight junction protein occludin in normal human epidermis. Methods: The immunofluorescence staining for occludin was performed with specimens taken from different areas of normal skin (4 from each of 7 different anatomical sites, including the scalp, face, posterior neck, upper arm, abdomen, lower back, and inner thigh). The degrees of the expression-intensity in each specimen were estimated with the reciprocals of positive end-point titer of occludin in an immunofluorescence study. Results: The highest degree expression-intensity of the TJ protein occludin among the different areas of normal epidermis was observed on the face and abdomen with a titer of 600. The lowest intensity of expression of occludin was seen in the epidermis from the upper arm. Skin specimens from the scalp, neck, back, and leg demonstrated intermediate degrees of the expression in intensity. Conclusion: The expression of occludin in the skin samples obtained from different locations of the body showed a statistically significant variation. This suggests that there is a certain degree of regional variation in the expression- intensity of TJ protein ``occludin`` in the human epidermis. (Korean J Dermatol 2008;46(2):196∼201)
나노크기의 수분입자를 생성하는 가습기가 정상인의 수분함량 및 경표피수분증발량에 미치는 영향에 관한 연구
오영재 ( Young Jae Oh ),유서례 ( Seo Rye Yoo ),고주연 ( Joo Yeon Ko ),노영석 ( Young Suck Ro ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.7
Background: Nano-sized water particles have been thought to moisturize the skin more effectively. However, clear benefits of humidifier generating nano-sized water particles on the skin have not been studied. Objective: The aim of this study is to examine the effects of humidifier generating nano-sized water particles on the skin by measuring the levels of the skin hydration state and skin barrier function with an objective, quantifiable method. Methods: A 4-week, randomized, case-control study was conducted in 40 healthy Korean women, aged between 20 and 39, and they were divided into two groups, the experimental and control groups. The experimental group used humidifier generating nano-sized water particles for 8 hours every night, during 4 weeks. Skin hydration and transepidermal water loss (TEWL) were measured every week on the forehead and cheek using corneometer and tewameter, respectively. Safety evaluations were also performed at each visit. Results: The baseline skin hydration and TEWL values showed no significant differences between the two groups. After 1 week of use, the experimental group showed significantly increased skin hydration values (p<0.001, p <0.0001) and decreased levels of TEWL values (p=0.017, p=0.025) as compared to the control group. During a 4-week study period, increased skin hydration and decreased TEWL were sustained in the experimental group. No adverse effects were observed in all the volunteers. Conclusion: These results show that humidifier, which generates nano-sized water particles, seems to positively affect skin hydration and skin barrier function. More studies and sufficient follow-up time are needed for the assessment of the humidifier generating nano-sized water particles. (Korean J Dermatol 2012;50(7):609∼613)