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- 저자 : 유기연 ( Ki Yon Rhew ) (검색결과 3 건)
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박민주(Minjoo Park),유기연(Ki Yon Rhew),한용문(Yongmoon Han) 대한약학회 2012 약학회지 Vol.56 No.6
In this present study, we determined whether or not there is an immunoadjuvant effect of ochnaflavone, a biflavone isolated from Lonicera japonica. As an antigenic source, the cell wall (CACW) of Candida albicans, a fungal pathogen, was used. CACW consists of 95% carbohydrate (mannan). In the experiments, BALB/c mice were immunized with emersion forms of CACW combined with or without ochnaflavone (Och) in the presence of IFA containing mineral oil or CACW alone. Then, the amounts of antisera collected from these mice groups were measured by the ELISA method. Data from these experiments showed that CACW combined with Och (CACW/Och/IFA) provoked the production of antisera app. 2.2 or 5 times more than the corresponding CACW/IFA or CACW alone (CACW/DPBS), respectively, in mice (P<0.05). We further examined the immune response type induced by Och. Analysis of the values of the IgG1/IgG2a ratios obtained from IgG isotyping revealed that Och induced Th2-immunity more dominantly than Th1. This finding was confirmed by cytokine profile. CACW/Och/IFA formulation induced IL-4 (Th2-type cytokine) more than IFNγ (Th1-type cytokine) as compared with CACW/IFA and CACW/DPBS formulations (P<0.05). All data combined, Och appears to have an immunoadjuvant activity that may convert Th1 immunity into Th2 immunity.
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양성희 ( Seong Hee Yang ),이기재 ( Kee Jae Lee ),유기연 ( Ki Yon Rhew ) 한국보건정보통계학회(구 한국보건통계학회) 2016 보건정보통계학회지 Vol.41 No.2
Objectives: Proper use of antibiotic for the treatment of acute otitis media (AOM) is important because it can improve the treatment effect and can reduce the risk of antibiotic-resistant bacteria. There has been no national wide study on the antibiotic use for AOM treatment in young ages in Korea. Therefore, we conducted a national wide study on the status of antibiotic prescription for the AOM treatment in young ages in Korea. Methods: The AOM outpatient data on the antibiotic prescription was obtained from Korean health insurance review and assessment service. The ratio and the factors influencing (type of AOM, patient’s age group, types of hospitals, specialty of the physician and the regions in Korea) on the antibiotic prescription was analyzed using multivariate binary logistic regression. Results: Total 388,994 cases were analyzed. The antibiotic was prescribed in 89.0%. Antibiotics were prescribed the most frequently in the pre-school ages (odds ratio [OR] 1.05; 95% confidence interval [CI], 1.00-1.11) and the least frequently in the adolescents (OR 0.81; 95% CI, 0.75-0.88). The suppurative AOM was more related to the use of antibiotics than non-suppurative AOM (OR 1.44; 95% CI, 1.39-1.50). The secondary hospital (OR 3.19; 95% CI, 2.65-3.85) and primary hospital (OR 8.40; 95% CI, 6.97-10.12) prescribed antibiotics more frequently compared to the tertiary hospital. Conclusions: Various factors are related to prescribing antibiotics for the treatment of AOM in pediatric patients. Antimicrobial prescribing guidelines for pediatric AOM patients would encourage appropriate use of antibiotics.
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한국임상약학회지에 게재된 논문의 통계 분석기법에 대한 고찰
양성희 ( Seong Hee Yang ),이태림 ( Tae Rim Lee ),이숙향 ( Suk Hyang Lee ),유기연 ( Ki Yon Rhew ) 한국보건정보통계학회 (구 한국보건통계학회) 2012 보건정보통계학회지 Vol.37 No.1
Objectives: Statistical analysis is fundamental to demonstrate internal validity of study results. The purpose of this study is to review statistical methods and errors in articles published in the Korean Journal of Clinical Pharmacy (KJCP). Methods: We reviewed appropriateness and validity of statistical methods in articles published in the KJCP from 2006 through 2010 using checklist for assessing the methodological and statistical validity. Frequency of applied inferential statistical methods and errors were analyzed using SPSS(R) version 12.0. Results: Total 85 original articles were reviewed. Among them, 19 articles used the descriptive statistics only, and 66 articles used both descriptive and inferential statistics. Frequently used methods were ANOVA (23.8%), t-test (19.8%), and χ2 test (12.9%). Errors of omission were found 45 times in 36 articles and errors of commission were found 41 times in 30 articles. Only 39.4% of papers were free from statistical errors. Conclusions: We could found various types of statistical errors in the articles published in the KJCP.Clinical researchers need to be more cautious in applying statistical methods of study to ensure internal validity of results.
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